Anti-inflammatory effect of the six compounds isolated from Nauclea officinalis Pierrc ex Pitard, and molecular mechanism of strictosamide via suppressing the NF-κB and MAPK signaling pathway in LPS-induced RAW 264.7 macrophages

2017 ◽  
Vol 196 ◽  
pp. 66-74 ◽  
Author(s):  
DongYu Li ◽  
JiaQuan Chen ◽  
JiQing Ye ◽  
XiaoTing Zhai ◽  
Jie Song ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Molecular Mechanism ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

Anti-inflammatory effects of soyasapogenol I-αa via downregulation of the MAPK signaling pathway in LPS-induced RAW 264.7 macrophages

2018 ◽  
Vol 113 ◽  
pp. 211-217 ◽  
Author(s):  
Seung Hwan Yang ◽  
Bao Le ◽  
Vasilis P. Androutsopoulos ◽  
Chigen Tsukamoto ◽  
Tae-Sun Shin ◽  
...  
Keyword(s):  
Signaling Pathway ◽  
Mapk Signaling ◽  
Mapk Signaling Pathway ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory

Anti-Inflammatory Effect of Chondria crassicaulis Ethanol Extract on MAPKs and NF-κB Signaling Pathway in LPS-Induced RAW 264.7 Macrophages

KSBB Journal ◽  
2017 ◽  
Vol 32 (4) ◽  
pp. 352-360
Author(s):  
Min-Ji Kim ◽  
Sun-Hee Park ◽  
Koth-Bong-Woo-Ri Kim ◽  
Jung-Su Choi ◽  
Dong-Hyun Ahn
Keyword(s):  
Signaling Pathway ◽  
Ethanol Extract ◽  
Raw 264.7 ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

scholarly journals Sargachromenol Purified from Sargassum horneri Inhibits Inflammatory Responses via Activation of Nrf2/HO-1 Signaling in LPS-Stimulated Macrophages

Marine Drugs ◽  
2021 ◽  
Vol 19 (9) ◽  
pp. 497
Author(s):  
Eui-Jeong Han ◽  
Thilina U. Jayawardena ◽  
Jae-Hyuk Jang ◽  
Ilekuttige Priyan Shanura Fernando ◽  
Youngheun Jee ◽  
...  
Keyword(s):  
Inflammatory Responses ◽  
Mapk Signaling ◽  
Sargassum Horneri ◽  
Heme Oxygenase 1 ◽  
Raw 264.7 ◽  
Related Factor ◽  
Nuclear Factor ◽  
Raw 264.7 Macrophages ◽  
Anti Inflammatory ◽  
Inflammatory Effect

In this study, we isolated sargachromenol (SC) from Sargassum horneri and evaluated its anti-inflammatory effect in lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages. SC did not show cytotoxicity at all concentrations and effectively increased the cell viability by reducing the nitric oxide (NO) and intracellular reactive oxygen species (ROS) production in LPS-stimulated RAW 264.7 macrophages. In addition, SC decreased the mRNA expression levels of inflammatory cytokines (IL-1β, IL-6, and TNF-α) and inflammatory mediators (iNOS and COX-2). Moreover, SC suppressed the activation of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and mitogen-activated protein kinase (MAPK) signaling, whereas activated the nuclear factor erythroid 2-related factor 2/heme oxygenase-1 (Nrf2/HO-1) signaling in LPS-stimulated RAW 264.7 macrophages. Interestingly, the anti-inflammatory effect of SC was abolished by the inhibition of HO-1 in LPS-stimulated RAW 264.7 macrophages. According to the results, this study suggests that the antioxidant capacity of SC leads to its anti-inflammatory effect and it potentially may be utilized in the nutraceutical and pharmaceutical sectors.

Sign in / Sign up

Export Citation Format

Share Document