Anti-inflammatory effect of leaves of Vernonia zeylanica in lipopolysaccharide-stimulated RAW 264.7 macrophages and carrageenan-induced rat paw-edema model

2021 ◽  
pp. 114030
Author(s):  
Dilani Rukshala ◽  
E. Dilip de Silva ◽  
B.V.Loshini R. Ranaweera ◽  
Narmada Fernando ◽  
Shiroma M. Handunnetti
Keyword(s):  
Raw 264.7 ◽  
Paw Edema ◽  
Raw 264.7 Macrophages ◽  
Rat Paw Edema ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

scholarly journals Retraction Note: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Inflammation ◽  
2020 ◽  
Author(s):  
Sachin S. Sakat ◽  
Kamaraj Mani ◽  
Yulia O. Demidchenko ◽  
Evgeniy A. Gorbunov ◽  
Sergey A. Tarasov ◽  
...  
Keyword(s):  
Paw Edema ◽  
Rat Paw Edema ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

scholarly journals RETRACTED ARTICLE: Release-Active Dilutions of Diclofenac Enhance Anti-inflammatory Effect of Diclofenac in Carrageenan-Induced Rat Paw Edema Model

Inflammation ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Sachin S. Sakat ◽  
Kamaraj Mani ◽  
Yulia O. Demidchenko ◽  
Evgeniy A. Gorbunov ◽  
Sergey A. Tarasov ◽  
...  
Keyword(s):  
Paw Edema ◽  
Rat Paw Edema ◽  
Edema Model ◽  
Retracted Article ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

scholarly journals TO STUDY OF ANTI-INFLAMMATORY EFFECT OF CALCIUM CHANNEL BLOCKERS IN RAT PAW EDEMA MODEL

2016 ◽  
Vol 3 (14) ◽  
pp. 493-500
Author(s):  
Anil Kumar Sharma ◽  
Azmatulla Shaik ◽  
Chitti Babu G ◽  
Khizer Hussain Afroze M ◽  
Praveen Agarwal
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blockers ◽  
Paw Edema ◽  
Rat Paw Edema ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

scholarly journals Ufasomes Mediated Cutaneous Delivery of Dexamethasone: Formulation and Evaluation of Anti-Inflammatory Activity by Carrageenin-Induced Rat Paw Edema Model

2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Rajkamal Mittal ◽  
Arvind Sharma ◽  
Sandeep Arora
Keyword(s):  
Oleic Acid ◽  
Entrapment Efficiency ◽  
Inflammatory Activity ◽  
Molar Ratio ◽  
Paw Edema ◽  
Rat Paw Edema ◽  
Transmission Electron ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Rat Paw

The purpose of study is to formulate and evaluate ufasomal gel of dexamethasone. Ufasomal suspension was made by sonication method using different concentrations of Span 80, Span 20 and cholesterol along with 25 mg of drug. Ufasomal gel was formulated by hydration method using carbopol 940. Ufasomal vesicles appeared as spherical and multilamellar under Transmission Electron Microscope. Ufasomal formulation prepared with drug to oleic acid molar ratio 8:2 (UF-2) produced greater number of vesicles and greater entrapment efficiency. UF-2 was optimized for further evaluation. The transdermal permeation and skin partitioning of from optimized formulation was significantly higher () as compared to plain drug and plain gel formulation which is due to presence of surfactant acting as permeation enhancer. Permeation of optimized formulation was found to be about 4.7 times higher than plain drug gel. Anti-inflammatory activity evaluated by inhibition Carrageenan induced rat paw edema model. Significant reduction of edema () was observed in comparison to the commercial product. Hence oleic acid based vesicles can be used as alternate carrier for topical delivery.

scholarly journals Denatonium benzoate decreases the effect of histamine in vitro and in rats

2020 ◽  
Vol 19 (9) ◽  
pp. 1879-1885
Author(s):  
Plamen I. Zagorchev ◽  
Vesela Yu Kokova ◽  
Elisaveta G. Apostolova ◽  
Milena N. Draganova-Filipova
Keyword(s):  
Smooth Muscle ◽  
Early Stage ◽  
Paw Edema ◽  
H1 Receptor ◽  
Rat Paw Edema ◽  
Denatonium Benzoate ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

Purpose: To evaluate the effect of denatonium benzoate (DB) in histamine-induced model of inflammation and the effect of the selective H1 receptor agonist (2-(2-Pyridyl) ethylamine) on rat gastric smooth muscle strips pretreated with DB.Methods: The anti-inflammatory effect of DB was evaluated in vivo on histamine-induced rat paw edema. In vitro studies on spontaneous muscle contraction were performed on smooth muscle strips isolated from rat gastric corpus.Results: The results showed a well-defined anti-inflammatory effect of DB (15 mg/kg) during the early stage of rat paw edema at the 15th (p < 0.001), 30th (p < 0.01) and 60th min (p < 0.001) compared to control. In vitro experiments indicated reduced spontaneous contractile activity of smooth muscle strips to H1 receptor agonist in the presence of DB (0.5 μM). The vascular effects of histamine are mediated by H1 receptors. Substances, which reduce the effect of histamine on the H1 receptors could influence the early stage of histamine-induced inflammation.Conclusion: The results show that the anti-inflammatory activity of DB probably is related to its antagonistic activity on histamine H1 receptors. The results would contribute to the search for new antiinflammatory drugs. Keywords: Denatonium benzoate, Inflammation, Histamine, Muscle contraction

scholarly journals Comparison of Anti-Inflammatory Effect of Ethanolic Extract of Carica Papaya Leaves and Indomethacin in Carrageenan Induced Rat Paw Edema Animal Model

2019 ◽  
Vol 16 (2) ◽  
pp. 49-53
Author(s):  
Afroza Sultana ◽  
Asma Khan ◽  
Rumana Afroz ◽  
Onayza Yasmeen ◽  
Muqbula Tasrin Aktar ◽  
...  
Keyword(s):  
Animal Model ◽  
Normal Saline ◽  
Carica Papaya ◽  
Ethanolic Extract ◽  
Paw Edema ◽  
Rat Paw Edema ◽  
Group I ◽  
Anti Inflammatory ◽  
Rat Paw ◽  
Inflammatory Effect

Background: Carica papaya is very useful vegetables for daily living. Objective: The purpose of the present study was to compare the anti-inflammatory effect of ethanolic extract of Carica papaya leaves and indomethacin in carrageenan induced rat paw edema animal model. Methodology: This was an animal study carried out in the Department of Pharmacology at Dhaka Medical College, Dhaka, Bangladesh during the period from July 2014 to June 2015 for a period of one (01) year. The leaves of Carica Papaya collected from Botanical garden, Mirpur, Dhaka, Bangladesh. The animals were divided into four groups. Inflammation was produced by injecting 0.1 ml of 1% carrageenan solution in normal saline in all experimental animals. Group I were served as control that received normal saline. Group II were received ethanolic extract of Carica Papaya. Group III were received ethanolic extract of Carica Papaya leaves. Group IV were received indomethacin. Result: The experiment was carried out on 48 Long Evan Norwegian rats. Rats were divided in 4 groups of six animals each. The mean initial antero-posterior diameter of rat’s paw of group I, II, III and IV were 3.83±0.04, 2.12±0.02, 1.74±0.01 and 1.60±0.03 respectively. The inhibition of edema formation were 44.64%, 54.57% and 58.22% in group II, III and IV respectively. Conclusion: In conclusion the Carica papaya leaves has anti-inflammatory effect Journal of Science Foundation 2018;16(2):49-53

Anti-Inflammatory and Cytotoxic Activities of Chichipegenin, Peniocerol, and Macdougallin Isolated from Myrtillocactus geometrizans (Mart. ex Pfeiff.) Con.

2011 ◽  
Vol 66 (1-2) ◽  
pp. 24-30 ◽  
Author(s):  
Juan Rodrigo Salazar ◽  
Mariano Martínez-Vazquez ◽  
Carlos L. Cespedes ◽  
Teresa Ramírez-Apan ◽  
Antonio Nieto-Camacho ◽  
...  
Keyword(s):  
Human Cancer ◽  
Cytotoxic Activities ◽  
Dependent Manner ◽  
Paw Edema ◽  
Medicinal Uses ◽  
Human Cancer Cell Lines ◽  
Rat Paw Edema ◽  
Edema Model ◽  
Anti Inflammatory ◽  
Rat Paw

The oleanane-type triterpene chichipegenin and the sterols peniocerol and macdougallin, isolated from Myrtillocactus geometrizans, showed anti-inflammatory activities in both the 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced mouse ear edema model and the carrageenan- induced rat paw edema model. All tested compounds inhibited the TPA-induced edema in a dose-dependent manner, with ED50 values less than or equal to that shown by indomethacin. Among them, peniocerol was the most active compound. However, only peniocerol and macdougallin reduced carrageenan-induced rat paw edema. On the other hand, peniocerol and macdougallin showed cytotoxicity against several human cancer cell lines. These results indicate that compounds isolated from M. geometrizans possess antiinflammatory and cytotoxic properties, and the presence of chichipegenin in the aerial parts could justify the medicinal uses attributed to the plant.

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