Simultaneous retinal pigment epithelium tear and lamellar macular hole evolving to a full-thickness macular hole after intravitreal injection

The authors report a case of a male patient affected by macular hole. In particular, a hyperreflective tissue was found on optical coherence tomography (OCT) examination in macular region, just above the retinal pigment epithelium (RPE). OCT angiography (OCTA) did not show the presence of vascular tissue, thus the hyperreflective material was ascribed to primary gliotic tissue. This case highlights the ability for Müller cells placed near macular holes to migrate up to the RPE and to produce gliotic tissue.

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CONGENITAL SIMPLE HAMARTOMA OF THE RETINAL PIGMENT EPITHELIUM WITH A FULL-THICKNESS MACULAR HOLE

Retinal Cases & Brief Reports ◽

10.1097/icb.0b013e318158de64 ◽

2009 ◽

Vol 3 (1) ◽

pp. 80-82 ◽

Cited By ~ 1

Author(s):

Ann Van de Moere ◽

J Ben Clark

Keyword(s):

Retinal Pigment Epithelium ◽

Macular Hole ◽

Pigment Epithelium ◽

Retinal Pigment ◽

Full Thickness ◽

Full Thickness Macular Hole

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Development of Stage 4 Macular Hole after Spontaneous Closure in a Patient with Stage 2 Macular Hole and a Lamellar Macular Hole-Associated Epiretinal Proliferation

Case Reports in Ophthalmology ◽

10.1159/000513132 ◽

2021 ◽

pp. 481-484

Author(s):

Masahisa Watanabe ◽

Harumasa Yokota ◽

Hiroshi Aso ◽

Hirotsugu Hanazaki ◽

Junya Hanaguri ◽

...

Keyword(s):

Visual Acuity ◽

Macular Hole ◽

Spontaneous Closure ◽

Surgical Removal ◽

Lamellar Macular Hole ◽

Full Thickness ◽

Stage 4 ◽

Full Thickness Macular Hole ◽

The Right ◽

Hole Closure

Herein, we report the longitudinal observation of a case with reopening of the macular hole associated with a lamellar macular hole-associated epiretinal proliferation (LHEP) followed by spontaneous closure in patients with stage 2 idiopathic macular hole. A 64-year-old woman was referred for the decreased visual acuity (VA) and acute anorthopia in the right eye. Funduscopy and optical coherence tomography (OCT) showed stage 2 full-thickness macular hole without posterior vitreous detachment (PVD) and operculum formation. Her best-corrected visual acuity (BCVA) was 20/32. One month later, the diameter of the macular hole was getting small and VA improved. Six months later, the macular hole was treated spontaneously with the attached hyaloid membrane to the macula by OCT and the BCVA improved to 20/20. Fourteen months after the first visit, the BCVA decreased to 20/50 and the patient was diagnosed with stage 4 macular hole with complete PVD. OCT showed full-thickness macular hole with a LHEP in the right eye. After 25G-gauge vitrectomy with the peeling of internal limiting membrane (ILM) and LHEP, the macular hole was closed and BCVA finally improved to 20/25. Spontaneous macular hole closure without PVD may rarely occur in patients with LHEP. The surgical removal of ILM and LHEP may contribute to the successful macular hole closure after vitrectomy.

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