Peripapillary and optic nerve head vessel density of glaucoma and healthy subjects from Afro-Caribbean and European descent: A pilot study

2021 ◽  
Author(s):  
L. Salazar-Quiñones ◽  
C. Yu-Wai-Man ◽  
A. De Antonio Ramirez ◽  
C.D. Méndez-Hernández ◽  
A. Daas ◽  
...  
Keyword(s):  
Pilot Study ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Healthy Subjects ◽  
Vessel Density ◽  
European Descent

Ocular Outcomes in Healthy Subjects Undergoing a Short-Term Head-Down Tilt Test

2021 ◽  
Vol 92 (8) ◽  
pp. 619-626
Author(s):  
Bahadr zelbaykal ◽  
Gkhan retmenolu ◽  
. Hakk Tunez
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Healthy Subjects ◽  
Corneal Thickness ◽  
Age Groups ◽  
Vessel Density ◽  
Tilt Test ◽  
Short Term ◽  
Disc Area ◽  
Before And After

PURPOSE: This study aimed to examine the effect of head-down tilt (HDT) on vascular autoregulation in different age groups anddetermine its effects on intraocular pressure (IOP) and central corneal thickness (CCT).METHODS: Included were 43 eyes of 23 men. The optic nerve head and parafoveal vascular densities were measured by optical coherence tomography angiography before and after 20 min 10 HDT. Also, the study comprised an examination of theIOP and CCT in a subset of 8 participants (14 eyes) in the sitting position and during 15 min of 10 HDT.RESULTS: Grid-based inside disc all-vessel density (GBID) was statistically significantly lower after the HDT test in subjects under 30 yr (1.26). Whole image and peripapillary capillary vessel density (WICVD, PCVD), and whole image and peripapillary all-vessel density (WIAVD, PAVD) were significantly higher after the HDT test in subjects ages 3039 yr (1.34, 2.16, 1.05, 1.72, respectively). Inside disc capillary, all-vessel density (IDCVD, IDAVD) and GBID were significantly higher after HDT in subjects over 40 yr (2.48, 2.15, 1.52, respectively). In a subset of eight participants, IOP was significantly higher (3.7 mmHg) and CCT was unchanged after 15 min of HDT.CONCLUSION: Our study showed that simulated microgravity induced optic nerve head vessel density at the inside disc area, especially in persons over 40 years. In addition, IOP was increased by HDT, although no change in CCT was observed.zelbaykal B, retmenolu G, Tunez H. Ocular outcomes in healthy subjects undergoing a short-term head-down tilt test. Aerosp Med Hum Perform. 2021; 92(8):619626.

scholarly journals The effect of Tetrahydrocannabinol on optic nerve head blood flow in healthy subjects

2019 ◽  
Vol 97 (S263) ◽  
Author(s):  
Nikolaus Hommer ◽  
Martin Kallab ◽  
Stephan Szegedi ◽  
Stefan Puchner ◽  
Martin Bauer ◽  
...  
Keyword(s):  
Blood Flow ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Healthy Subjects

Reproducibility of macular and optic nerve head vessel density measurements by swept-source optical coherence tomography angiography

2019 ◽  
Vol 30 (4) ◽  
pp. 756-763 ◽  
Author(s):  
José Ignacio Fernández-Vigo ◽  
Bachar Kudsieh ◽  
Ana Macarro-Merino ◽  
Pedro Arriola-Villalobos ◽  
José María Martínez-de-la-Casa ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Optical Coherence Tomography Angiography ◽  
Central Zone ◽  
Vessel Density ◽  
Optical Coherence ◽  
Outer Retina ◽  
Swept Source ◽  
Capillary Plexus

Purpose: To assess the reproducibility of swept-source optical coherence tomography angiography (SS-OCTA) for macular and optic nerve head (ONH) vessel density (VD). Methods: Cross-sectional study using the Triton OCTA (Topcon, Tokyo, Japan), for VD (%) measurements in 40 eyes of 40 healthy subjects on two 6 × 6 mm scans of the macula and ONH across five subfields (central, superior, inferior, temporal, and nasal) at different segmentation levels: superficial capillary plexus (SCP), deep capillary plexus (DCP), outer retina, and choriocapillaris. Reproducibility values were summarized as intraclass correlation coefficients (ICCs) and coefficients of variations (CV). Results: ICCs for the macular VD measurements in the central zone were 0.874, 0.770, 0.575, 0.718 at the levels SCP, DCP, outer retina, and choriocapillaris, respectively, while worse ICCs were obtained for the parafoveal subfields (ICC ⩽ 0.589); CVs were 2.8%–6.7%. The reproducibility of the ONH superficial VD was ICC = 0.941 for the papillary region and was ICC = 0.499–0.853 for the peripapillary zone; CVs ranged from 4.8% to 17%. Peripapillary VD showed an ICC = 0.533–0.770 in the DCP layer, and 0.572–0.828 in the choriocapillaris. Lowest VD were obtained for the macular SCP and DCP (23% and 22%, respectively), in the foveal zone, while greatest VD were recorded in the nasal and temporal peripapillary subfields at the level of the choriocapillaris (both 68%). Conclusions: The new SS-OCTA software served to quantify macular and ONH VD with a reproducibility that was good in the central zones (foveal and papillary, respectively) and moderate in the peripheral zones (parafoveal and peripapillary).

scholarly journals Laser speckle flowgraphy derived characteristics of optic nerve head perfusion in normal tension glaucoma and healthy individuals: a Pilot study

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Anna Sophie Mursch-Edlmayr ◽  
Nikolaus Luft ◽  
Dominika Podkowinski ◽  
Michael Ring ◽  
Leopold Schmetterer ◽  
...  
Keyword(s):  
Pilot Study ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Normal Tension Glaucoma ◽  
Laser Speckle ◽  
Laser Speckle Flowgraphy ◽  
Healthy Individuals

scholarly journals Changes in Optic Nerve Head Vessel Density After Acute Primary Angle Closure Episode

2019 ◽  
Vol 60 (2) ◽  
pp. 552 ◽  
Author(s):  
Sasan Moghimi ◽  
Mona SafiZadeh ◽  
Masoud Aghsaei Fard ◽  
Nazgol Motamed-Gorji ◽  
Nassim Khatibi ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Vessel Density ◽  
Angle Closure ◽  
Acute Primary Angle Closure ◽  
Primary Angle Closure

scholarly journals Evaluation of the optic nerve head vessel density in patients with limited scleroderma

2021 ◽  
Vol 13 ◽  
pp. 251584142199538
Author(s):  
Hilal Kılınç Hekimsoy ◽  
Ali Mehmet Şekeroğlu ◽  
Ali Mert Koçer ◽  
Vedat Hekimsoy ◽  
Ali Akdoğan
Keyword(s):  
Optical Coherence Tomography ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Vessel Density ◽  
Optical Coherence ◽  
Control Subjects ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Healthy Control ◽  
Limited Scleroderma

Objectives: To investigate the optical coherence tomography angiography (OCTA) parameters of the optic nerve head and peripapillary retina and to assess macular and peripapillary retinal nerve fiber layer (RNFL) thickness by using spectral-domain optical coherence tomography (SD-OCT) in patients with limited scleroderma and to compare these results with those of healthy control subjects. Materials and Methods: 42 patients with a confirmed diagnosis of limited scleroderma and 32 age- and sex-matched healthy control subjects were included in the study. OCTA was performed for the radial peripapillary capillary plexus (RPCP) whole image, inside disc, and peripapillary vessel densities in all participants with XR Avanti AngioVue OCTA (Optovue, Fremont, California, USA). OCT images were obtained with Spectralis OCT with eye-tracking dual-beam technology (Heidelberg Engineering GmbH, Heidelberg, Germany), and peripapillary RNFL thickness was evaluated with circle program. The data from the right eyes of all participants were used for statistical analysis. Results: No significant difference was found between the radial RPCP whole image, inside disc, and peripapillary vessel density values or the RNFL parameters of the scleroderma patients when compared with the controls ( p > 0.05 for all). Conclusion: Decreased peripapillary vessel density on OCTA, which can be an early sign of glaucoma, could not be observed in scleroderma patients in this study. However, further long-term studies are still needed to identify glaucoma tendency in patients with scleroderma before clinically detectable glaucoma.

scholarly journals Optic Nerve Head Vessel Density Assessment in Recovered COVID-19 Patients

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Barbara Burgos-Blasco ◽  
Noemi Güemes-Villahoz ◽  
Beatriz Vidal-Villegas ◽  
Julian Garcia-Feijoo ◽  
Juan Donate-Lopez ◽  
...  
Keyword(s):  
Optic Nerve ◽  
Optic Nerve Head ◽  
Vessel Density ◽  
Density Assessment
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