The role of grip strength and short physical performance battery test in predicting chemotherapy-related outcomes in older adults with cancer

2021 ◽  
Author(s):  
Fahad A. Almugbel ◽  
Narhari Timilshina ◽  
Efthymios Papadopoulos ◽  
Laith Al-Showbaki ◽  
Shabbir M.H. Alibhai
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Physical Performance ◽  
Short Physical Performance Battery

scholarly journals SCREENING FOR LOW SHORT PHYSICAL PERFORMANCE BATTERY SCORES: CAN GRIP STRENGTH AND SINGLE CHAIR STAND BE USEFUL?

2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S679-S680
Author(s):  
Paulo H Chaves
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Physical Performance ◽  
Nursing Home Residents ◽  
Short Physical Performance Battery ◽  
Clinical Settings ◽  
Or Efficiency ◽  
Chair Stand ◽  
Screening Approach ◽  
Time Space

Abstract The clinical value of low Short Physical Performance Battery (SPPB) scores for identification of older adults at-disability-risk who may benefit from structured intervention is well-established. Feasibility concerns – e.g., time, space constraints – are factors that often preclude SPPB implementation in clinical settings. We assessed whether grip strength (GS) and/or single chair stand (SCS), simple and highly feasible tests, could be useful for clinical identification of older adults with poor SPPB performance. Cross-sectional study using most recent data (Round 7) from the National Health and Aging Trends Study, which enrolled a large U.S. representative sample of Medicare beneficiaries 65 years and older (baseline round: 2011; yearly follow-ups). Nursing home residents were excluded. Sample size was 4,612. Outcome: poor SPPB performance (score <8). Low GS: <20 Kg (women) or <30 Kg (men), and able to do a SCS without use of arm (yes/no) were predictors. Logistic regression, areas under the curves (AUC), and accuracy statistics were computed. AUC for low GS was 0.66, and SCS inability was 0.68; when both tests were considered together, AUC increased significantly: 0.76. Among those SCS-unable (n=752), 95.6% had SPPB<8. A two-stage screening approach; i.e., detection of SCS inability first, followed by low GS in those SCS-able resulted in a net-sensitivity of 75.3%, and net-specificity of 83.5%. Sequential screening with SCS and GS testing might offer a case finding screening approach appealing to busy clinical settings from feasibility, accuracy, and/or efficiency perspectives for identification of older adults with low SPPB who may benefit from established interventions.

Serum GDF15 Level Is Independent of Sarcopenia in Older Asian Adults

Gerontology ◽  
2021 ◽  
pp. 1-7
Author(s):  
Ha Thi Nga ◽  
Il-Young Jang ◽  
Da Ae Kim ◽  
So Jeong Park ◽  
Jin Young Lee ◽  
...  
Keyword(s):  
Grip Strength ◽  
Muscle Mass ◽  
Physical Performance ◽  
Gait Speed ◽  
Muscle Metabolism ◽  
Short Physical Performance Battery ◽  
Muscle Physiology ◽  
Skeletal Muscle Index ◽  
Age Related

Background: Growth differentiation factor 15 (GDF15), induced by tissue inflammation and mitochondrial stress, has received significant attention as a biomarker of mitochondrial dysfunction and has been implicated in various age-related diseases. However, the association between circulating GDF15 and sarcopenia-associated outcomes in older adults remains to be established. Aim: To validate previous experimental data and to investigate the possible role of GDF15 in aging and muscle physiology in humans, this study examined serum GDF15 levels in relation to sarcopenia-related parameters in a cohort of older Asian adults. Methods: Muscle mass and muscle function-related parameters, such as grip strength, gait speed, chair stands, and short physical performance battery score were evaluated by experienced nurses in 125 geriatric participants with or without sarcopenia. Sarcopenia was diagnosed using the Asian-specific cutoff points. Serum GDF15 levels were measured using an enzyme immunoassay kit. Results: Serum GDF15 levels were not significantly different according to sarcopenia status, muscle mass, muscle strength, and physical performance and were not associated with the skeletal muscle index, grip strength, gait speed, time to complete 5 chair stands, and short physical performance battery score, regardless of adjustments for sex, age, and BMI. Conclusions: These findings indicate that the definite role of GDF15 on muscle metabolism observed in animal models might not be evident in humans and that elevated GDF15 levels might not predict the risk for sarcopenia, at least in older Asian adults.

Does physical performance and muscle strength predict future personal and nursing care services in community-dwelling older adults aged 75+?

2021 ◽  
pp. 140349482097909
Author(s):  
Jonathan Vaarst ◽  
Eleanor Boyle ◽  
Sonja Vestergaard ◽  
Lars G. Hvid ◽  
Elsa S. Strotmeyer ◽  
...  
Keyword(s):  
Older Adults ◽  
Home Care ◽  
Grip Strength ◽  
Physical Performance ◽  
Nursing Care ◽  
Community Dwelling ◽  
Short Physical Performance Battery ◽  
Home Nursing ◽  
Home Nursing Care ◽  
Community Dwelling Older Adults

Aim: The objective of this study was to investigate if grip strength or the short physical performance battery could predict the rate of receiving two different types of home care services: (a) personal care and (b) home nursing care for community-dwelling older adults aged 75+ years. Methods: A secondary data analysis of a prospective cohort study including 323 community-dwelling older adults. Measures of grip strength and the short physical performance battery were incorporated in a nationally regulated preventive home visit programme. Referral to personal and home nursing care were obtained from an administrative database with an average follow-up of 4.1 years. The rate of receiving the individual home care services and the study measures were determined using multivariable Cox proportional hazards models controlling for a priori selected covariates (age, sex, living status, obesity, smoking and prior use of home care). Results: The mean age was 81.7 years with 58.8% being women. The rate of receiving personal care differed between the short physical performance battery groups but not between the grip strength groups after adjusting for all covariates with hazard ratios (95% confidence intervals) of 1.90 (1.29–2.81) and 1.41 (0.95–2.08), respectively. The rate of receiving home nursing care differed between both the short physical performance battery and grip strength groups after adjusting for all covariates with hazard ratios of 2.03 (1.41–2.94) and 1.48 (1.01–2.16), respectively. Conclusions: The short physical performance battery was associated with the rate of receiving both personal care and home nursing care. The short physical performance battery can be used to predict home care needs of community-dwelling older adults aged 75+ years.

Short Physical Performance Battery (SPPB) score as a discriminator of dynapenic abdominal obesity among community-dwelling older adults

2021 ◽  
Vol 42 (2) ◽  
pp. 467-472
Author(s):  
Elane Priscila Rosa dos Santos ◽  
Caroline Fátima Ribeiro Silva ◽  
Daniela Gonçalves Ohara ◽  
Areolino Pena Matos ◽  
Ana Carolina Pereira Nunes Pinto ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Performance ◽  
Abdominal Obesity ◽  
Community Dwelling ◽  
Short Physical Performance Battery ◽  
Community Dwelling Older Adults

Prospective associations of plasma growth differentiation factor 15 with physical performance and cognitive functions in older adults

2022 ◽  
Author(s):  
Lingxiao He ◽  
Philipe de Souto Barreto ◽  
Juan Luis Sánchez Sánchez ◽  
Yves Rolland ◽  
Sophie Guyonnet ◽  
...  
Keyword(s):  
Older Adults ◽  
Grip Strength ◽  
Physical Performance ◽  
Cognitive Functions ◽  
Community Dwelling ◽  
Cognitive Score ◽  
Growth Differentiation Factor 15 ◽  
Clinically Significant ◽  
One Year ◽  
Community Dwelling Older Adults

Abstract Background Growth differentiation factor 15 (GDF15) has been associated with several age-related disorders, but its associations with functional abilities in community-dwelling older adults are not well studied. Methods The study was a secondary analysis on 1096 community-dwelling older adults (aged 69 to 94 years) recruited from the Multidomain Alzheimer’s Preventive Trial. Plasma GDF15 was measured one year after participants’ enrolment. Annual data of physical performance (grip strength and short physical performance battery [SPPB]) and global cognitive functions (mini-mental state examination [MMSE] and a composite cognitive score) were measured for four years. Adjusted mixed-effects linear models were performed for cross-sectional and longitudinal association analyses. Results A higher GDF15 was cross-sectionally associated with a weaker grip strength (β = -1.1E-03, 95%CI [-2.0E-03, -1.5E-04]), a lower SPPB score (β = -3.1E-04, 95%CI [-5.4E-04, -9.0E-05]) and worse cognitive functions (β = -2.4E-04, 95%CI [-3.3E-04, -1.6E-04] for composite cognitive score; β = -4.0E-04, 95%CI [-6.4E-04, -1.6E-04] for MMSE). Participants with higher GDF15 demonstrated greater longitudinal declines in SPPB (β = -1.0E-04, 95%CI [-1.7E-04, -2.0E-05]) and composite cognitive score (β = -2.0E-05, 95%CI [-4.0E-05, -3.6E-06]). The optimal initial GDF15 cutoff values for identifying participants with minimal clinically significant decline after one year were 2189 pg/mL for SPPB (AUC: 0.580) and 2330 pg/mL for composite cognitive score (AUC: 0.587). Conclusions Plasma GDF15 is cross-sectionally and longitudinally associated with lower-limb physical performance and global cognitive function in older adults. Circulating GDF15 alone has limited capacity of discriminating older adults who will develop clinically significant functional declines.

scholarly journals Functional Age Predicted by Electronic Short Physical Performance Battery Can Detect Frailty Status in Older Adults [Corrigendum]

2021 ◽  
Vol Volume 16 ◽  
pp. 1631-1632
Author(s):  
Hee-Won Jung ◽  
Taeyang Jin ◽  
Ji Yeon Baek ◽  
Seongjun Yoon ◽  
Eunju Lee ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Performance ◽  
Short Physical Performance Battery ◽  
Frailty Status

Physical Performance Predictors for Incident Dementia Among Japanese Community-Dwelling Older Adults

2019 ◽  
Vol 99 (9) ◽  
pp. 1132-1140
Author(s):  
Takehiko Doi ◽  
Kota Tsutsumimoto ◽  
Sho Nakakubo ◽  
Min-Ji Kim ◽  
Satoshi Kurita ◽  
...  
Keyword(s):  
Older Adults ◽  
Risk Assessment ◽  
Grip Strength ◽  
Physical Performance ◽  
Performance Level ◽  
Community Dwelling ◽  
Sit To Stand ◽  
Dementia Risk ◽  
Incident Dementia ◽  
Community Dwelling Older Adults

Abstract Background Evaluating physical performance could facilitate dementia risk assessment. However, findings differ regarding which type of physical performance best predicts dementia. Objective The objective of this study was to examine the association between physical performance and incidence of dementia in Japanese community-dwelling older adults. Design This was a prospective study of community-dwelling older adults. Methods Of 14,313 invited individuals who were ≥ 65 years old, 5104 agreed to participate from 2011 to 2012, and 4086 (52% women; mean age = 72.0 years) met the criteria. Baseline assessments of the following physical performance indicators were obtained: grip strength, the Five-Times Sit-to-Stand Test, and the Timed “Up & Go” Test. The physical performance level in each test was categorized as C1 (highest), C2 (middle–high), C3 (middle–low), or C4 (lowest) on the basis of sex-stratified quartile values. Incident dementia status was obtained from medical records that were updated monthly. Results During follow-up (mean duration = 42.9 months), there were 243 incident cases of dementia (5.9%). Log-rank test results indicated that a lower physical performance level constituted a significant risk factor for dementia. After adjustment for covariates, Cox proportional hazards models (reference: highest physical performance level [C1]) demonstrated that the Five-Times Sit-to-Stand Test in the group with the lowest physical performance level (hazard ratio = 1.69; 95% CI = 1.10–2.59) was significantly associated with a risk of dementia. Likewise, the Timed “Up & Go” Test in the group with the lowest physical performance level (hazard ratio = 1.54; 95% CI = 1.01–2.35) was significantly associated with a risk of dementia. However, grip strength was not significantly associated with a risk of dementia. Limitations This study was limited by the use of medical record data. Conclusions A lower mobility-related physical performance level was associated with dementia risk. Dementia risk assessment should include an adequate evaluation of physical function.

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