LB941 Photodynamic therapy (PDT) with aminolevulinic acid (ALA) 20% and blue light reduces occurrence of actinic keratoses (AK) and de novo non-melanoma skin cancers (NMSCs) in patients with field cancerization

Background: The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. Objective: The current study compared the ability of topical and systemic ALA–PDT as well as topical ALA–PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. Methods: Groups of hairless mice were exposed daily to UV radiation and weekly to ALA–PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA–PDT and mice exposed only to UV radiation. Results: Weekly topical or systemic ALA–PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA–PDT performed with blue light. This was observed even when weekly ALA–PDT was started after 8 weeks of UV exposure. Conclusion: Large-surface topical ALA–PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.

Download Full-text

Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light

Journal of the American Academy of Dermatology ◽

10.1067/mjd.2001.114288 ◽

2001 ◽

Vol 45 (1) ◽

pp. 96-104 ◽

Cited By ~ 105

Author(s):

Edward W. Jeffes ◽

Jerry L. McCullough ◽

Gerald D. Weinstein ◽

Ross Kaplan ◽

Scott D. Glazer ◽

...

Keyword(s):

Photodynamic Therapy ◽

Blue Light ◽

Aminolevulinic Acid ◽

Actinic Keratoses ◽

Acid Hydrochloride

Download Full-text

Aminolevulinic acid and methyl aminolevulinate equally effective in topical photodynamic therapy for non-melanoma skin cancers

Journal of the European Academy of Dermatology and Venereology ◽

10.1111/jdv.13558 ◽

2016 ◽

Vol 30 (3) ◽

pp. 420-423 ◽

Cited By ~ 24

Author(s):

M. Tarstedt ◽

M. Gillstedt ◽

A.-M. Wennberg Larkö ◽

J. Paoli

Keyword(s):

Photodynamic Therapy ◽

Aminolevulinic Acid ◽

Skin Cancers ◽

Methyl Aminolevulinate ◽

Melanoma Skin

Download Full-text

Use of Photodynamic Therapy for Treatment of Actinic Keratoses in Organ Transplant Recipients

BioMed Research International ◽

10.1155/2013/349526 ◽

2013 ◽

Vol 2013 ◽

pp. 1-7 ◽

Cited By ~ 18

Author(s):

Christina Wlodek ◽

Faisal R. Ali ◽

John T. Lear

Keyword(s):

Photodynamic Therapy ◽

Organ Transplant ◽

Solid Organ ◽

Transplant Recipients ◽

Actinic Keratoses ◽

Organ Transplant Recipients ◽

Skin Cancers ◽

Effective Treatment Modality ◽

Nonmelanoma Skin Cancers

Solid organ transplant recipients are predisposed to actinic keratoses (AK) and nonmelanoma skin cancers, owing to the lifelong immunosuppression required. Today, increasing numbers of organ transplants are being performed and organ transplant recipients (OTRs) are surviving much longer. Photodynamic therapy (PDT) is proving a highly effective treatment modality for AK amongst this susceptible group of patients. Following an overview of the pathogenesis of AK amongst OTRs, the authors review current safety and efficacy data and how this relates to the role of PDT for the treatment of AK in OTRs.

Download Full-text