A phase II study of photodynamic therapy (PDT) with aminolevulinic acid HCl (ALA) 20% topical solution + blue light versus aminolevulinic acid HCl topical solution vehicle (VEH) + blue light for the treatment of actinic keratoses (AKs) on the upper extremi

2013 ◽  
Vol 68 (4) ◽  
pp. AB156
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Phase Ii ◽  
Aminolevulinic Acid ◽  
Phase Ii Study ◽  
Actinic Keratoses ◽  
Topical Solution

scholarly journals Photodynamic Therapy With Aminolevulinic Acid Topical Solution andVisible Blue Light in the Treatment of Multiple Actinic Keratoses of the Faceand Scalp

2004 ◽  
Vol 140 (1) ◽  
Author(s):  
Daniel J. Piacquadio ◽  
Diana M. Chen ◽  
Harold F. Farber ◽  
Joseph F. Fowler, Jr ◽  
Scott D. Glazer ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Aminolevulinic Acid ◽  
Actinic Keratoses ◽  
Topical Solution

Photodynamic therapy of patients having multiple actinic keratoses with topical 5-aminolevulinic acid (ALA) and non-laser blue light

1998 ◽  
Vol 16 ◽  
pp. S208
Author(s):  
Edward Jeffes ◽  
Jerry McCullough ◽  
Gerald Weinstein ◽  
Toni Shull ◽  
Ross Kaplan ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Aminolevulinic Acid ◽  
Actinic Keratoses

Multiple Large-Surface Photodynamic Therapy Sessions with Topical or Systemic Aminolevulinic Acid and Blue Light in UV-Exposed Hairless Mice

2004 ◽  
Vol 8 (2) ◽  
pp. 131-139 ◽  
Author(s):  
Younan Liu ◽  
Gilles Viau ◽  
Robert Bissonnette
Keyword(s):  
Squamous Cell Carcinoma ◽  
Photodynamic Therapy ◽  
Cell Carcinoma ◽  
Blue Light ◽  
Uv Radiation ◽  
Squamous Cell ◽  
Aminolevulinic Acid ◽  
Hairless Mice ◽  
Free Survival ◽  
Actinic Keratoses

Background: The use of photodynamic therapy (PDT) with topical aminolevulinic acid (ALA) on large skin surfaces has recently been reported for patients with multiple actinic keratoses. Objective: The current study compared the ability of topical and systemic ALA–PDT as well as topical ALA–PDT with blue light to delay the appearance of UV-induced skin cancer using the hairless mouse as a model. Methods: Groups of hairless mice were exposed daily to UV radiation and weekly to ALA–PDT. Tumor-free survival was compared for mice exposed to UV and treated weekly with ALA–PDT and mice exposed only to UV radiation. Results: Weekly topical or systemic ALA–PDT was able to delay the induction of skin tumors. A significant difference in tumor-free survival was also observed for both actinic keratoses and invasive squamous cell carcinoma in mice treated weekly with topical ALA–PDT performed with blue light. This was observed even when weekly ALA–PDT was started after 8 weeks of UV exposure. Conclusion: Large-surface topical ALA–PDT with blue light can delay the appearance of UV-induced actinic keratoses and squamous cell carcinoma in hairless mice.

Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light

2001 ◽  
Vol 45 (1) ◽  
pp. 96-104 ◽  
Author(s):  
Edward W. Jeffes ◽  
Jerry L. McCullough ◽  
Gerald D. Weinstein ◽  
Ross Kaplan ◽  
Scott D. Glazer ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Blue Light ◽  
Aminolevulinic Acid ◽  
Actinic Keratoses ◽  
Acid Hydrochloride
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