scholarly journals 1468 BPM31510 improves wound healing and skin integrity in epidermolysis bullosa patients

2018 ◽  
Vol 138 (5) ◽  
pp. S249
Author(s):  
M. Sanchez ◽  
I. Herskovitz ◽  
S. Hu
Keyword(s):  
Wound Healing ◽  
Epidermolysis Bullosa ◽  
Skin Integrity

scholarly journals High Local Concentrations of Intradermal MSCs Restore Skin Integrity and Facilitate Wound Healing in Dystrophic Epidermolysis Bullosa

2015 ◽  
Vol 23 (8) ◽  
pp. 1368-1379 ◽  
Author(s):  
Tobias Kühl ◽  
Markus Mezger ◽  
Ingrid Hausser ◽  
Rupert Handgretinger ◽  
Leena Bruckner-Tuderman ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epidermolysis Bullosa ◽  
Dystrophic Epidermolysis Bullosa ◽  
Skin Integrity

Analysis of wound healing-related chemokines in the sera of epidermolysis bullosa patients

2016 ◽  
Vol 84 (1) ◽  
pp. e143
Author(s):  
Inkin Ujiie ◽  
Yasuyuki Fujita ◽  
Wakana Matsumura ◽  
Shotaro Suzuki ◽  
Satoru Shinkuma ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epidermolysis Bullosa

Hydro-responsive wound dressings for treating hard-to-heal wounds: a narrative review of the clinical evidence

2021 ◽  
Vol 30 (12) ◽  
pp. 980-992
Author(s):  
Karen Ousey ◽  
Heather Hodgson ◽  
Mark G Rippon ◽  
Alan A Rogers
Keyword(s):  
Wound Healing ◽  
Clinical Evidence ◽  
Narrative Review ◽  
Wound Dressings ◽  
Fluid Loss ◽  
Subsequent Infection ◽  
First Line ◽  
Wound Healing Response ◽  
Skin Integrity ◽  
Wound Bed Preparation

A break in skin integrity must be repaired as quickly as possible to avoid excess blood and fluid loss, and to minimise the onset of infection. Hard-to-heal wounds, in which the progression of the wound healing response is compromised, present several challenges to healing (for example, the presence of devitalised tissue acting as a physical barrier to healing and as a focus for bacterial contamination with the potential for subsequent infection). The objective of this article is to present, as a narrative review, the clinical evidence supporting the use of a unique hydro-responsive wound dressing (HydroClean, HRWD1, PAUL HARTMANN AG, Germany). The dressing provides a simple treatment option to address a number of clinical challenges clinicians must overcome in order to facilitate wound healing progression. These studies demonstrated that this product supported successful debridement/cleansing of a wide variety of wounds, including hard-to-heal wounds, enabled wound bed preparation, and lead to positive healing outcomes, including in wounds that previously had failed to heal. The simplicity of using HRWD1 as a single dressing can help clinicians overcome a variety of challenges when treating both acute and hard-to-heal wounds, which, with the benefit of proven patient outcomes, could make it an ideal choice for a first-line treatment.

scholarly journals Complete Cytolysis and Neonatal Lethality in Keratin 5 Knockout Mice Reveal Its Fundamental Role in Skin Integrity and in Epidermolysis Bullosa Simplex

2001 ◽  
Vol 12 (6) ◽  
pp. 1775-1789 ◽  
Author(s):  
Bettina Peters ◽  
Jutta Kirfel ◽  
Heinrich Büssow ◽  
Miguel Vidal ◽  
Thomas M. Magin
Keyword(s):  
Epidermolysis Bullosa ◽  
Basal Cells ◽  
Epidermolysis Bullosa Simplex ◽  
Keratin 5 ◽  
Neonatal Lethality ◽  
Keratin Filaments ◽  
Wide Range ◽  
Skin Integrity

In human patients, a wide range of mutations in keratin (K) 5 or K14 lead to the blistering skin disorder epidermolysis bullosa simplex. Given that K14 deficiency does not lead to the ablation of a basal cell cytoskeleton because of a compensatory role of K15, we have investigated the requirement for the keratin cytoskeleton in basal cells by inactivating the K5 gene in mice. We report that the K5− / − mice die shortly after birth, lack keratin filaments in the basal epidermis, and are more severely affected than K14− / −mice. In contrast to the K14− / −mice, we detected a strong induction of the wound-healing keratin K6 in the suprabasal epidermis of cytolyzed areas of postnatal K5− / − mice. In addition, K5 and K14 mice differed with respect to tongue lesions. Moreover, we show that in the absence of K5 and other type II keratins, residual K14 and K15 aggregated along hemidesmosomes, demonstrating that individual keratins without a partner are stable in vivo. Our data indicate that K5 may be the natural partner of K15 and K17. We suggest that K5 null mutations may be lethal in human epidermolysis bullosa simplex patients.

Wound healing and epidermolysis bullosa

1988 ◽  
Vol 124 (5) ◽  
pp. 732-733 ◽  
Author(s):  
D. M. Carter
Keyword(s):  
Wound Healing ◽  
Epidermolysis Bullosa

scholarly journals Reprogramming of keratin biosynthesis by sulforaphane restores skin integrity in epidermolysis bullosa simplex

2007 ◽  
Vol 104 (36) ◽  
pp. 14460-14465 ◽  
Author(s):  
M. L. Kerns ◽  
D. DePianto ◽  
A. T. Dinkova-Kostova ◽  
P. Talalay ◽  
P. A. Coulombe
Keyword(s):  
Epidermolysis Bullosa ◽  
Epidermolysis Bullosa Simplex ◽  
Skin Integrity

The efficacy of trimethoprim in wound healing of patients with epidermolysis bullosa: A feasibility trial

2012 ◽  
Vol 66 (2) ◽  
pp. 264-270 ◽  
Author(s):  
Irene Lara-Corrales ◽  
Patricia C. Parkin ◽  
Derek Stephens ◽  
Jill Hamilton ◽  
Gideon Koren ◽  
...  
Keyword(s):  
Wound Healing ◽  
Epidermolysis Bullosa ◽  
Feasibility Trial
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