Osteogenesis and new bone formation of alendronate-immobilized porous PLGA microspheres in a rat calvarial defect model

2017 ◽  
Vol 52 ◽  
pp. 277-286 ◽  
Author(s):  
Jae Yong Lee ◽  
Sung Eun Kim ◽  
Young-Pil Yun ◽  
Sung-Wook Choi ◽  
Daniel I. Jeon ◽  
...  
Keyword(s):  
Bone Formation ◽  
Plga Microspheres ◽  
Calvarial Defect ◽  
New Bone Formation ◽  
Defect Model ◽  
Rat Calvarial Defect

Investigation of the effects of semaphorin 3A on new bone formation in a rat calvarial defect model

2019 ◽  
Vol 47 (3) ◽  
pp. 473-483 ◽  
Author(s):  
Sevinç Kenan ◽  
Özen Doğan Onur ◽  
Seyhun Solakoğlu ◽  
Tuğba Kotil ◽  
Mustafa Ramazanoğlu ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Defect ◽  
Semaphorin 3A ◽  
New Bone Formation ◽  
Defect Model ◽  
Rat Calvarial Defect

Bone formation in a rat calvarial defect model after transplanting autogenous bone marrow with beta-tricalcium phosphate

2010 ◽  
Vol 112 (3) ◽  
pp. 270-277 ◽  
Author(s):  
Nobuaki Shirasu ◽  
Takaaki Ueno ◽  
Yasuhisa Hirata ◽  
Azumi Hirata ◽  
Toshimasa Kagawa ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Formation ◽  
Tricalcium Phosphate ◽  
Autogenous Bone ◽  
Calvarial Defect ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Rat Calvarial Defect

scholarly journals Fabrication and Evaluation of Porous Beta-Tricalcium Phosphate/Hydroxyapatite (60/40) Composite as a Bone Graft Extender Using Rat Calvarial Bone Defect Model

2013 ◽  
Vol 2013 ◽  
pp. 1-9 ◽  
Author(s):  
Jae Hyup Lee ◽  
Mi Young Ryu ◽  
Hae-Ri Baek ◽  
Kyung Mee Lee ◽  
Jun-Hyuk Seo ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Graft ◽  
Tricalcium Phosphate ◽  
Calvarial Defect ◽  
Micro Ct ◽  
Porous Substrate ◽  
New Bone Formation ◽  
Defect Model ◽  
Beta Tricalcium Phosphate ◽  
Bone Graft Extender

Beta-tricalcium phosphate (β-TCP) and hydroxyapatite (HA) are widely used as bone graft extenders due to their osteoconductivity and high bioactivity. This study aims to evaluate the possibility of using porous substrate with composite ceramics (β-TCP: HA = 60% : 40%, 60TCP40HA) as a bone graft extender and comparing it with Bio-Oss. Interconnectivity and macroporosity ofβ-TCP porous substrate were 99.9% and 83%, respectively, and the macro-porosity of packed granule after crushing was 69%. Calvarial defect model with 8 mm diameter was generated with male Sprague-Dawley rats and 60TCP40HA was implanted. Bio-Oss was implanted for a control group and micro-CT and histology were performed at 4 and 8 weeks after implantation. The 60TCP40HA group showed better new bone formation than the Bio-Oss group and the bone formation at central area of bone defect was increased at 8 weeks in micro-CT and histology. The percent bone volume and trabecular number of the 60TCP40HA group were significantly higher than those of Bio-Oss group. This study confirms the usefulness of the porous 60TCP40HA composite as a bone graft extender by showing increased new bone formation in the calvarial defect model and improved bone formation both quantitatively and qualitatively when compared to Bio-Oss.

Evaluation of bone formation guided by DNA/protamine complex with FGF-2 in an adult rat calvarial defect model

2014 ◽  
Vol 102 (8) ◽  
pp. 1669-1676 ◽  
Author(s):  
Yosuke Shinozaki ◽  
Masako Toda ◽  
Jun Ohno ◽  
Minoru Kawaguchi ◽  
Hirofumi Kido ◽  
...  
Keyword(s):  
Bone Formation ◽  
Calvarial Defect ◽  
Defect Model ◽  
Adult Rat ◽  
Rat Calvarial Defect

scholarly journals Evaluation of Open Hollow Hydroxyapatite Microsphere on Bone Regeneration in Rat Calvarial Defects

2019 ◽  
Author(s):  
Youqu Shen ◽  
Mohamed Rahaman ◽  
Yongxian Liu ◽  
Yue-Wern Huang
Keyword(s):  
Surface Roughness ◽  
Bone Formation ◽  
Bone Regeneration ◽  
Convex Surface ◽  
Total Surface Area ◽  
Calvarial Defect ◽  
New Bone Formation ◽  
Calvarial Defects ◽  
The Difference ◽  
Rat Calvarial Defect

AbstractHollow hydroxyapatite (HA) microspheres showed the ability to facilitate bone regeneration in rats with non-healing calvarial defects. However, new bone formation in the rat calvarial defect implanted with the closed HA microspheres was limited. The objective of this work is to evaluate size-, time, and structure-dependent bone regeneration between open and closed HA microspheres in an osseous model. Open HA microspheres were obtained by sectioning closed HA microspheres. The open HA microsphere had dense convex surface and rough and porous concave surface. For both size ranges (ϕ106-150 μm vs. ϕ212-250 μm), the open HA microsphere were more effective in facilitating bone regeneration than the closed HA microspheres in rat calvarial defects. Bone regeneration in the open HA microspheres (49 ± 7% for ϕ106-150 μm; 40 ± 8% for ϕ212-250 μm) were higher than the closed HA microsphere (26 ± 8% for ϕ106-150 μm; 30 ± 9% for ϕ212-250 μm) at 12 weeks. Furthermore, the open HA microspheres of smaller size showed a significant increase in bone regeneration than the open HA microspheres of larger size at both 6 weeks and 12 weeks. The difference in bone regeneration between these microspheres could be due to their differences in microstructures, namely curvature, concavity, porosity, surface roughness, and total surface area available for cells to attached to.

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