DNA as molecular target of analogous palladium and platinum anti-Trypanosoma cruzi compounds: A comparative study

2011 ◽  
Vol 105 (12) ◽  
pp. 1704-1711 ◽  
Author(s):  
Marisol Vieites ◽  
Pablo Smircich ◽  
Mariana Pagano ◽  
Lucía Otero ◽  
Francielle Luane Fischer ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Molecular Target

Comparative study of the biological properties of Trypanosoma cruzi I genotypes in a murine experimental model

2015 ◽  
Vol 29 ◽  
pp. 110-117 ◽  
Author(s):  
Lissa Cruz ◽  
Angie Vivas ◽  
Marleny Montilla ◽  
Carolina Hernández ◽  
Carolina Flórez ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Experimental Model ◽  
Biological Properties

Comparative study of Trypanosoma rangeli and Trypanosoma cruzi telomeres

2002 ◽  
Vol 120 (2) ◽  
pp. 305-308 ◽  
Author(s):  
Miguel A. Chiurillo ◽  
Andreina Peralta ◽  
José L. Ramı́rez
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Trypanosoma Rangeli

Synthesis of quinoline derivatives as potential cysteine protease inhibitors

2020 ◽  
Author(s):  
Marina MS Andrade ◽  
Luan C Martins ◽  
Gabriel VL Marques ◽  
Carla A Silva ◽  
Gilson Faria ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Protease Inhibitors ◽  
Cysteine Protease ◽  
Inhibitory Activity ◽  
Molecular Targets ◽  
Cysteine Proteases ◽  
Leishmania Species ◽  
Molecular Target ◽  
Quinoline Derivatives ◽  
Cysteine Protease Inhibitors

Aim: Cysteine proteases are important molecular targets involved in the replication, virulence and survival of parasitic organisms, including Trypanosoma and Leishmania species. Methodology & results: Analogs of the 7-chloro- N-[3-(morpholin-4-yl)propyl]quinolin-4-amine were synthesized and their inhibitory activity against the enzymes cruzain and rhodesain as well as against promastigotes forms of Leishmania species and epimastigotes forms of Trypanosoma cruzi were evaluated. Five compounds showed activity against both enzymes with IC50 values ranging from 23 to 123 μM. Among these, compounds 3 and 4 displayed leishmanicidal activity; compound 4 was the most promising with IC50 values <10 μM and no cytotoxicity for uninfected cells. Conclusion: The results obtained indicate that cysteine proteases are likely to be the molecular target of compounds 3 and 4.

Trypanosoma cruzi cell invasion and traffic: Influence of Coxiella burnetii and pH in a comparative study between distinct infective forms

2007 ◽  
Vol 43 (1) ◽  
pp. 22-36 ◽  
Author(s):  
Maria Cecília Fernandes ◽  
Carolina L’Abbate ◽  
Walter Kindro Andreoli ◽  
Renato Arruda Mortara
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Coxiella Burnetii ◽  
Cell Invasion

scholarly journals Comparative Efficacies of TAK-187, a Long-Lasting Ergosterol Biosynthesis Inhibitor, and Benznidazole in Preventing Cardiac Damage in a Murine Model of Chagas' Disease

2005 ◽  
Vol 49 (4) ◽  
pp. 1556-1560 ◽  
Author(s):  
Milagros Corrales ◽  
Rubén Cardozo ◽  
María Asunción Segura ◽  
Julio A. Urbina ◽  
Miguel Angel Basombrío
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Chagas Disease ◽  
Murine Model ◽  
Ergosterol Biosynthesis ◽  
Cardiac Damage ◽  
Experimental Animals ◽  
Biosynthesis Inhibitor

ABSTRACT We carried out a comparative study of benznidazole and TAK-187, a long-lasting ergosterol biosynthesis inhibitor, with a murine model of Chagas' disease. The results indicated that TAK-187 was more effective than benznidazole in preventing Trypanosoma cruzi-induced cardiac damage in experimental animals.

scholarly journals Comparative study of random amplified polymorphic dna of trypanosoma cruzi isolates from paraguay.

1999 ◽  
Vol 27 (3) ◽  
pp. 427-431
Author(s):  
SAYUMI BABA ◽  
TAMAMI MATSUMOTO ◽  
HIROJI KANBARA ◽  
MAKOTO SAKAMOTO ◽  
MARISEL MALDONADO ◽  
...  
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Random Amplified Polymorphic Dna

Characterization of ecto-phosphatase activities of Trypanosoma cruzi: A comparative study between Colombiana and Y strains

Acta Tropica ◽  
2006 ◽  
Vol 100 (1-2) ◽  
pp. 88-95 ◽  
Author(s):  
P.M.L. Dutra ◽  
L.C. Couto ◽  
A.H.C.S. Lopes ◽  
J.R. Meyer-Fernandes
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Phosphatase Activities

scholarly journals A comparative study of Trypanosoma cruzi infection in sylvatic mammals from a protected and a disturbed area in the Argentine Chaco

Acta Tropica ◽  
2016 ◽  
Vol 155 ◽  
pp. 34-42 ◽  
Author(s):  
M.M. Orozco ◽  
G.F. Enriquez ◽  
M.V. Cardinal ◽  
R.V. Piccinali ◽  
R.E. Gürtler
Keyword(s):  
Trypanosoma Cruzi ◽  
Comparative Study ◽  
Disturbed Area ◽  
Cruzi Infection
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