Structural Studies of the Alzheimer’s Amyloid Precursor Protein Copper-binding Domain Reveal How it Binds Copper Ions

Copper Ions ◽

Binding Domain ◽

Precursor Protein ◽

Copper Binding ◽

Structural Studies

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

Crystallization and preliminary crystallographic studies of the copper-binding domain of the amyloid precursor protein of Alzheimer's disease

10.1107/s1744309104029744 ◽

2004 ◽

Vol 61 (1) ◽

pp. 93-95 ◽

Cited By ~ 8

Author(s):

Geoffrey K.-W. Kong ◽

Denise Galatis ◽

Kevin J. Barnham ◽

Galina Polekhina ◽

Julian J. Adams ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Domain ◽

Precursor Protein ◽

The Copper Binding Domain of the Amyloid Precursor Protein of Alzheimer's Disease can Modulate Copper Homeostasis and Regulate Amyloid Aß Production

Prion Diseases and Copper Metabolism ◽

10.1016/b978-1-898563-87-7.50014-8 ◽

2002 ◽

pp. 102-107

Author(s):

Gerd Multhaup ◽

Thomas A. Bayer

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Copper Homeostasis ◽

Binding Domain ◽

Precursor Protein ◽

O3-04-06 Structural and functional analysis of the Alzheimer's disease amyloid precursor protein copper binding domain

Neurobiology of Aging ◽

10.1016/s0197-4580(04)80203-3 ◽

2004 ◽

Vol 25 ◽

pp. S60 ◽

Cited By ~ 3

Author(s):

Roberto Cappai ◽

Geoffrey Kong ◽

William McKinstry ◽

Denise Galatis ◽

Julian Adams ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Functional Analysis ◽

Binding Domain ◽

Precursor Protein ◽

Acta Crystallographica Section F Structural Biology and Crystallization Communications ◽

Structure of Alzheimer's disease amyloid precursor protein copper-binding domain at atomic resolution

10.1107/s1744309107041139 ◽

2007 ◽

Vol 63 (10) ◽

pp. 819-824 ◽

Cited By ~ 20

Author(s):

Geoffrey Kwai-Wai Kong ◽

Julian J. Adams ◽

Roberto Cappai ◽

Michael W. Parker

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Domain ◽

Precursor Protein ◽

Atomic Resolution ◽

Structure of the Alzheimer's Disease Amyloid Precursor Protein Copper Binding Domain

Journal of Biological Chemistry ◽

10.1074/jbc.m300629200 ◽

2003 ◽

Vol 278 (19) ◽

pp. 17401-17407 ◽

Cited By ~ 185

Author(s):

Kevin J. Barnham ◽

William J. McKinstry ◽

Gerd Multhaup ◽

Denise Galatis ◽

Craig J. Morton ◽

...

Keyword(s):

Alzheimer’S Disease ◽

Alzheimer's Disease ◽

Binding Domain ◽

Precursor Protein ◽

Effects of Cu Ions and Explicit Water Molecules on the Copper Binding Domain of Amyloid Precursor Protein APP(131–189): A Molecular Dynamics Study

The Journal of Physical Chemistry B ◽

10.1021/jp200260e ◽

2011 ◽

Vol 115 (29) ◽

pp. 9224-9235 ◽

Cited By ~ 6

Author(s):

Qiang Wang ◽

Nick H. Werstiuk ◽

James R. Kramer ◽

Russell A. Bell

Keyword(s):

Molecular Dynamics ◽

Binding Domain ◽

Precursor Protein ◽

Water Molecules ◽

Copper Binding ◽

Explicit Water ◽

Cu Ions

The E1 Copper Binding Domain of Full-Length Amyloid Precursor Protein Promotes Epithelial to Mesenchymal Transition in DU145 Cells in an Isoform-Specific Manner

International Journal of Biochemistry Research & Review ◽

10.9734/ijbcrr/2015/14873 ◽

2015 ◽

Vol 6 (1) ◽

pp. 1-10 ◽

Cited By ~ 2

Author(s):

Mallory Gough ◽

Craig Delury ◽

Edward Parkin

Keyword(s):

Epithelial To Mesenchymal Transition ◽

Binding Domain ◽

Full Length ◽

Precursor Protein ◽

Copper Binding ◽

Mesenchymal Transition ◽

Specific Manner ◽

Du145 Cells

The N‐terminal copper‐binding domain of the amyloid precursor protein protects against Cu 2+ neurotoxicity in vivo

The FASEB Journal ◽

10.1096/fj.03-1349fje ◽

2004 ◽

Vol 18 (14) ◽

pp. 1701-1703 ◽

Cited By ~ 29

Author(s):

Waldo F. Cerpa ◽

María I. Barría ◽

Marcelo A. Chacón ◽

Miriam Suazo ◽

Mauricio González ◽

...

Keyword(s):

Binding Domain ◽

Precursor Protein ◽

The E1 copper binding domain of full-length amyloid precursor protein mitigates copper-induced growth inhibition in brain metastatic prostate cancer DU145 cells

Biochemical and Biophysical Research Communications ◽

10.1016/j.bbrc.2014.10.004 ◽

2014 ◽

Vol 453 (4) ◽

pp. 741-747 ◽

Cited By ~ 7

Author(s):

Mallory Gough ◽

Sophee Blanthorn-Hazell ◽

Craig Delury ◽

Edward Parkin

Keyword(s):

Prostate Cancer ◽

Growth Inhibition ◽

Metastatic Prostate Cancer ◽

Binding Domain ◽

Full Length ◽

Precursor Protein ◽

Copper Binding ◽

Du145 Cells

The Amyloid Precursor Protein Copper Binding Domain Histidine Residues 149 and 151 Mediate APP Stability and Metabolism

Journal of Biological Chemistry ◽

10.1074/jbc.m112.355743 ◽

2012 ◽

Vol 287 (32) ◽

pp. 26840-26853 ◽

Cited By ~ 17

Author(s):

Loredana Spoerri ◽

Laura J. Vella ◽

Chi L. L. Pham ◽

Kevin J. Barnham ◽

Roberto Cappai

Keyword(s):

Binding Domain ◽

Precursor Protein ◽

Copper Binding ◽

Histidine Residues