scholarly journals Molecular Characterization of Two Homologs of the Caenorhabditis elegans Cadmium-Responsive Gene cdr-1: cdr-4 and cdr-6

2008 ◽  
Vol 376 (3) ◽  
pp. 621-633 ◽  
Author(s):  
Jie Dong ◽  
Windy A. Boyd ◽  
Jonathan H. Freedman
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization ◽  
Responsive Gene

scholarly journals Molecular characterization of the transition to mid-life in Caenorhabditis elegans

AGE ◽  
2012 ◽  
Vol 35 (3) ◽  
pp. 689-703 ◽  
Author(s):  
D. Mark Eckley ◽  
Salim Rahimi ◽  
Sandra Mantilla ◽  
Nikita V. Orlov ◽  
Christopher E. Coletta ◽  
...  
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization

Molecular characterization of the metabotropic glutamate receptor family in Caenorhabditis elegans

2006 ◽  
Vol 34 (5) ◽  
pp. 942-948 ◽  
Author(s):  
J. Dillon ◽  
N.A. Hopper ◽  
L. Holden-Dye ◽  
V. O'Connor
Keyword(s):  
Caenorhabditis Elegans ◽  
Molecular Characterization ◽  
Metabotropic Glutamate Receptors ◽  
Metabotropic Glutamate Receptor ◽  
Model Organism ◽  
Metabotropic Glutamate ◽  
C Elegans ◽  
Genes Encoding ◽  
G Protein Coupled

mGluRs (metabotropic glutamate receptors) are G-protein-coupled receptors that play an important neuromodulatory role in the brain. Glutamatergic transmission itself plays a fundamental role in the simple nervous system of the model organism Caenorhabditis elegans, but little is known about the contribution made by mGluR signalling. The sequenced genome of C. elegans predicts three distinct genes, mgl-1, mgl-2 and mgl-3 (designated Y4C6A.2). We have used in silico and cDNA analyses to investigate the genes encoding mgls. Our results indicate that mgl genes constitute a gene family made up of three distinct subclasses of receptor. Our transcript analysis highlights potential for complex gene regulation with respect to both expression and splicing. Further, we identify that the predicted proteins encoded by mgls harbour structural motifs that are likely to regulate function. Taken together, this molecular characterization provides a platform to further investigate mGluR function in the model organism C. elegans.

Molecular characterization of the Caenorhabditis elegans REF-1 family member, hlh-29/hlh-28

2007 ◽  
Vol 1769 (1) ◽  
pp. 5-19 ◽  
Author(s):  
Tracee L. McMiller ◽  
Denise Sims ◽  
Tameshia Lee ◽  
Tiffany Williams ◽  
Casonya M. Johnson
Keyword(s):  
Caenorhabditis Elegans ◽  
Family Member ◽  
Molecular Characterization
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