A Randomized, Placebo-Controlled Clinical Trial of Chiropractic and Medical Prophylactic Treatment of Adults With Tension-Type Headache: Results From a Stopped Trial

2009 ◽  
Vol 32 (5) ◽  
pp. 344-351 ◽  
Author(s):  
Howard Vernon ◽  
Gwen Jansz ◽  
Charles H. Goldsmith ◽  
Cameron McDermaid
Keyword(s):  
Clinical Trial ◽  
Prophylactic Treatment ◽  
Tension Type Headache ◽  
Controlled Clinical Trial ◽  
Type Headache

Treatment of tension-type headache with articulatory and suboccipital soft tissue therapy: A double-blind, randomized, placebo-controlled clinical trial

2014 ◽  
Vol 18 (4) ◽  
pp. 576-585 ◽  
Author(s):  
Gemma V. Espí-López ◽  
Antonia Gómez-Conesa ◽  
Anna Arnal Gómez ◽  
Josep Benítez Martínez ◽  
Ángel Oliva Pascual-Vaca ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Soft Tissue ◽  
Tension Type Headache ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Tissue Therapy ◽  
Type Headache ◽  
Soft Tissue Therapy

Treatment of Chronic Tension-Type Headache with Botulinum Toxin: A Double-Blind, Placebo-Controlled Clinical Trial

Cephalalgia ◽  
2004 ◽  
Vol 24 (8) ◽  
pp. 675-680 ◽  
Author(s):  
M Padberg ◽  
SFTM de Bruijn ◽  
RJ de Haan ◽  
DLJ Tavy
Keyword(s):  
Clinical Trial ◽  
Botulinum Toxin ◽  
Botulinum Toxin A ◽  
Symptomatic Treatment ◽  
Tension Type Headache ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Chronic Tension Type Headache ◽  
Significant Difference ◽  
Type Headache

Botulinum toxin is increasingly advocated as effective treatment in chronic tension-type headache. We conducted a randomized, placebo-controlled clinical trial to prove efficacy of botulinum toxin in chronic tension-type headache. Patients were randomly assigned to receive botulinum toxin (maximum 100 units) or placebo (saline) in muscles with increased tenderness. After 12 weeks there was no significant difference between the two treatment groups in decrease of headache intensity on VAS (-3.5 mm, 95% confidence interval (CI) -20 to +13), mean number of headache days (-7%; 95% CI -20 to +4), headache hours per day (-1.4%; 95% CI -3.9 to +1.1), days on which symptomatic treatment was taken (-1.9%; 95% CI -11 to +7) and number of analgesics taken per day (-0.01; 95% CI -0.25-0.22). There was no significant difference in patient's assessment of improvement after week 4, 8 and 12. Botulinum toxin was not proven effective in treatment of chronic tension-type headache. Increased muscle tenderness might not be as important in pathophysiology of chronic tension-type headache as hitherto believed.

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