Brain-derived neurotrophic factor gene delivery in an animal model of multiple sclerosis using bone marrow stem cells as a vehicle

2009 ◽  
Vol 210 (1-2) ◽  
pp. 40-51 ◽  
Author(s):  
Tapas K. Makar ◽  
Christopher T. Bever ◽  
Ishwar S. Singh ◽  
Walter Royal ◽  
Surasri Nandan Sahu ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Gene Delivery ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bone Marrow Stem Cells ◽  
Factor Gene

scholarly journals Human Brain–Derived Neurotrophic Factor Gene-Modified Bone Marrow Mesenchymal Stem Cells Combined With Erythropoietin Can Improve Acute Spinal Cord Injury

Dose-Response ◽  
2020 ◽  
Vol 18 (1) ◽  
pp. 155932582091093
Author(s):  
YongLei Li ◽  
Hongchen Wang ◽  
Xiaofang Ding ◽  
Jiancheng Shen ◽  
Haitao Zhou ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Bone Marrow ◽  
Spinal Cord Injury ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Factor Gene ◽  
Cord Injury ◽  
Marrow Mesenchymal Stem Cells

Objective: To assess the effect as well as mechanism of bone marrow mesenchymal stem cells (BMSCs) modified by the human brain–derived neurotrophic factor gene combined with erythropoietin (EPO) in the treatment of acute spinal cord injury (SCI) in rats. Methods: The Brain-derived neurotrophic factor (BDNF) gene was transected by a virus vector. Rats with SCI were randomly split into following groups: The normal saline (NS) group, the EPO group, The Basso, Beattie, and Bresnahan scores, messenger RNA BDNF expression, and apoptosis rates were compared between the 4 groups at 1, 3, 7, 14, and 21 days after SCI. Results: At 7, 14, and 21 days after operation, the expression of the BDNF gene in the other 3 groups was higher than that of the NS group, and the difference was statistically significant ( P < .05). The apoptosis rate in the combined group was less than that of NS, EPO, and BDNF/BMSC groups, and the differences were statistically significant ( P < .05). Conclusion: Brain-derived neurotrophic factor gene-modified BMSC transplantation combined with EPO can promote the repair of nerve function after SCI in rats.

Brain-derived neurotrophic factor (BDNF) gene delivery into the CNS using bone marrow cells as vehicles in mice

2004 ◽  
Vol 356 (3) ◽  
pp. 215-219 ◽  
Author(s):  
T.K. Makar ◽  
D. Trisler ◽  
M.A. Eglitis ◽  
M.M. Mouradian ◽  
S. Dhib-Jalbut
Keyword(s):  
Bone Marrow ◽  
Gene Delivery ◽  
Neurotrophic Factor ◽  
Bone Marrow Cells ◽  
Brain Derived Neurotrophic Factor ◽  
Bdnf Gene ◽  
Marrow Cells

R095: Transplantation of Bone-Marrow Stem Cells in an Animal Model

2007 ◽  
Vol 137 (2_suppl) ◽  
pp. P183-P183
Author(s):  
Akihiro Matsuoka ◽  
Takako Kondo ◽  
Richard T Miyamoto ◽  
Eri Hashino
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Animal Model ◽  
Bone Marrow Stem Cells

DNA/PEI nano-particles for gene delivery of rat bone marrow stem cells

2008 ◽  
Vol 313-314 ◽  
pp. 116-120 ◽  
Author(s):  
Hyun Hee Ahn ◽  
Min Suk Lee ◽  
Mi Hee Cho ◽  
Yu Na Shin ◽  
Jung Hwa Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Gene Delivery ◽  
Bone Marrow Stem Cells ◽  
Nano Particles ◽  
Rat Bone
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