Autologous mesenchymal stem cell transplantation in patients with multiple sclerosis

2013 ◽  
Vol 333 ◽  
pp. e383
Author(s):  
Y. Motuzova ◽  
O. Ionova ◽  
M. Zafranskaya ◽  
A. Borisov ◽  
D. Nizheharodova ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation

A Consensus Statement Addressing Mesenchymal Stem Cell Transplantation for Multiple Sclerosis: It’s Time!

2010 ◽  
Vol 6 (4) ◽  
pp. 500-506 ◽  
Author(s):  
Christopher Siatskas ◽  
Natalie L. Payne ◽  
Martin A. Short ◽  
Claude C. A. Bernard
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Consensus Statement ◽  
Mesenchymal Stem Cell Transplantation

Phase 1 Clinical Trial of Autologous Mesenchymal Stem Cell Transplantation in Multiple Sclerosis (IN8-2.003)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. IN8-2.003-IN8-2.003
Author(s):  
J. Cohen ◽  
A. Bar-Or ◽  
R. Bermel ◽  
E. Fisher ◽  
R. Fox ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Phase 1 ◽  
Mesenchymal Stem Cell Transplantation ◽  
Phase 1 Clinical Trial

The therapeutic potential of mesenchymal stem cell transplantation as a treatment for multiple sclerosis: consensus report of the International MSCT Study Group

2010 ◽  
Vol 16 (4) ◽  
pp. 503-510 ◽  
Author(s):  
Mark S Freedman ◽  
Amit Bar-Or ◽  
Harold L Atkins ◽  
Dimitrios Karussis ◽  
Francesco Frassoni ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cells ◽  
Central Nervous System ◽  
Nervous System ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation

Current therapies for multiple sclerosis effectively reduce inflammation, but do little in terms of repair to the damaged central nervous system. Cell-based therapies may provide a new strategy for bolstering regeneration and repair through neuro-axonal protection or remyelination. Mesenchymal stem cells modulate pathological responses in experimental autoimmune encephalitis, alleviating disease, but also stimulate repair of the central nervous system through the release of soluble factors. Autologous and allogeneic mesenchymal stem cells have been safely administered to individuals with hemato-oncological diseases and in a limited number of patients with multiple sclerosis. It is therefore reasonable to move mesenchymal stem cells transplantation into properly controlled human studies to explore their potential as a treatment for multiple sclerosis. Since it is likely that the first such studies will probably involve only small numbers of patients in a few centers, we formed an international panel comprising multiple sclerosis neurology and stem cell experts, as well as immunologists. The aims were to derive a consensus on the utilization of mesenchymal stem cells for the treatment of multiple sclerosis, along with protocols for the culture of the cells and the treatment of patients. This article reviews the consensus derived from our group on the rationale for mesenchymal stem cell transplantation, the methodology for generating mesenchymal stem cells and the first treatment protocol for multiple sclerosis patients.

Mesenchymal stem cell transplantation to treat multiple sclerosis

2011 ◽  
pp. 520-534 ◽  
Author(s):  
Don Mahad ◽  
Sarah M. Planchon ◽  
Jeffrey A. Cohen
Keyword(s):  
Multiple Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation

scholarly journals Safety and Immunological Effects of Mesenchymal Stem Cell Transplantation in Patients With Multiple Sclerosis and Amyotrophic Lateral Sclerosis

2010 ◽  
Vol 67 (10) ◽  
Author(s):  
Dimitrios Karussis ◽  
Clementine Karageorgiou ◽  
Adi Vaknin-Dembinsky ◽  
Basan Gowda-Kurkalli ◽  
John M. Gomori ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Amyotrophic Lateral Sclerosis ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation ◽  
Immunological Effects ◽  
Lateral Sclerosis

scholarly journals The potential therapeutic effect of adipose tissue-derived mesenchymal stem cell transplantation on cuprizone model of multiple sclerosis in the mice

2019 ◽  
Vol 0 (0) ◽  
pp. 0-0
Author(s):  
mona barkat ◽  
Amany El-Agwany ◽  
Ayman Khanfor ◽  
Melad Kelada ◽  
Doaa Abdel-monsif ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Therapeutic Effect ◽  
Mesenchymal Stem Cell Transplantation

Phase 1 Clinical Trial of Autologous Mesenchymal Stem Cell Transplantation in Multiple Sclerosis (S30.002)

Neurology ◽  
2012 ◽  
Vol 78 (Meeting Abstracts 1) ◽  
pp. S30.002-S30.002
Author(s):  
J. Cohen ◽  
A. Bar-Or ◽  
R. Bermel ◽  
E. Fisher ◽  
R. Fox ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Clinical Trial ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Phase 1 ◽  
Mesenchymal Stem Cell Transplantation ◽  
Phase 1 Clinical Trial

Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: A pilot study

2010 ◽  
Vol 227 (1-2) ◽  
pp. 185-189 ◽  
Author(s):  
Bassem Yamout ◽  
Roula Hourani ◽  
Haytham Salti ◽  
Wissam Barada ◽  
Taghrid El-Hajj ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
Bone Marrow ◽  
Stem Cell ◽  
Pilot Study ◽  
Mesenchymal Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Mesenchymal Stem Cell Transplantation
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