scholarly journals Effective reduction of the interleukin-1β transcript in osteoarthritis-prone guinea pig chondrocytes via short hairpin RNA mediated RNA interference influences gene expression of mediators implicated in disease pathogenesis

2011 ◽  
Vol 19 (12) ◽  
pp. 1449-1457 ◽  
Author(s):  
K.S. Santangelo ◽  
A.L. Bertone
Keyword(s):  
Gene Expression ◽  
Rna Interference ◽  
Guinea Pig ◽  
Short Hairpin Rna ◽  
Interleukin 1Β ◽  
Disease Pathogenesis ◽  
Hairpin Rna ◽  
Effective Reduction ◽  
Short Hairpin

scholarly journals Lentiviral Vector-Mediated Delivery of Short Hairpin RNA Results in Persistent Knockdown of Gene Expression in Mouse Brain

2003 ◽  
Vol 14 (18) ◽  
pp. 1799-1807 ◽  
Author(s):  
Chris Van den Haute ◽  
Kristel Eggermont ◽  
Bart Nuttin ◽  
Zeger Debyser ◽  
Veerle Baekelandt
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Lentiviral Vector ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Short Hairpin

scholarly journals CHD8 Is an ATP-Dependent Chromatin Remodeling Factor That Regulates β-Catenin Target Genes

2008 ◽  
Vol 28 (12) ◽  
pp. 3894-3904 ◽  
Author(s):  
Brandi A. Thompson ◽  
Véronique Tremblay ◽  
Grace Lin ◽  
Daniel A. Bochar
Keyword(s):  
Gene Expression ◽  
Rna Interference ◽  
Chromatin Remodeling ◽  
Gene Transcription ◽  
Chromatin Structure ◽  
Target Genes ◽  
Promoter Regions ◽  
Hairpin Rna ◽  
Short Hairpin ◽  
Targeted Gene Expression

ABSTRACT ATP-dependent chromatin remodeling by the CHD family of proteins plays an important role in the regulation of gene transcription. Here we report that full-length CHD8 interacts directly with β-catenin and that CHD8 is also recruited specifically to the promoter regions of several β-catenin-responsive genes. Our results indicate that CHD8 negatively regulates β-catenin-targeted gene expression, since short hairpin RNA against CHD8 results in the activation of several β-catenin target genes. This regulation is also conserved through evolution; RNA interference against kismet, the apparent Drosophila ortholog of CHD8, results in a similar activation of β-catenin target genes. We also report the first demonstration of chromatin remodeling activity for a member of the CHD6-9 family of proteins, suggesting that CHD8 functions in transcription through the ATP-dependent modulation of chromatin structure.

Comparison of approaches for efficient gene silencing induced by microRNA-based short hairpin RNA and indicator gene expression

2009 ◽  
Vol 37 (4) ◽  
pp. 1831-1839 ◽  
Author(s):  
Z. X. Shan ◽  
Q. X. Lin ◽  
C. Y. Deng ◽  
Z. L. Zhou ◽  
H. H. Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Silencing ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Efficient Gene ◽  
Short Hairpin

scholarly journals Specific Knockdown of OCT4 in Human Embryonic Stem Cells by Inducible Short Hairpin RNA Interference

Stem Cells ◽  
2009 ◽  
Vol 27 (4) ◽  
pp. 776-782 ◽  
Author(s):  
Gaetano Zafarana ◽  
Stuart R. Avery ◽  
Katie Avery ◽  
Harry D. Moore ◽  
Peter W. Andrews
Keyword(s):  
Stem Cells ◽  
Rna Interference ◽  
Embryonic Stem Cells ◽  
Human Embryonic Stem Cells ◽  
Embryonic Stem ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Short Hairpin ◽  
Short Hairpin Rna Interference
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