Comparison of approaches for efficient gene silencing induced by microRNA-based short hairpin RNA and indicator gene expression

2009 ◽  
Vol 37 (4) ◽  
pp. 1831-1839 ◽  
Author(s):  
Z. X. Shan ◽  
Q. X. Lin ◽  
C. Y. Deng ◽  
Z. L. Zhou ◽  
H. H. Tan ◽  
...  
Keyword(s):  
Gene Expression ◽  
Gene Silencing ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Efficient Gene ◽  
Short Hairpin

scholarly journals Lentiviral Vector-Mediated Delivery of Short Hairpin RNA Results in Persistent Knockdown of Gene Expression in Mouse Brain

2003 ◽  
Vol 14 (18) ◽  
pp. 1799-1807 ◽  
Author(s):  
Chris Van den Haute ◽  
Kristel Eggermont ◽  
Bart Nuttin ◽  
Zeger Debyser ◽  
Veerle Baekelandt
Keyword(s):  
Gene Expression ◽  
Mouse Brain ◽  
Lentiviral Vector ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
Short Hairpin

scholarly journals Short Hairpin RNA Gene Silencing of Prolyl Hydroxylase-2 with a Minicircle Vector Improves Neovascularization of Hindlimb Ischemia

2014 ◽  
Vol 25 (1) ◽  
pp. 41-49 ◽  
Author(s):  
Maarten A. Lijkwan ◽  
Alwine A. Hellingman ◽  
Ernst J. Bos ◽  
Koen E.A. van der Bogt ◽  
Mei Huang ◽  
...  
Keyword(s):  
Gene Silencing ◽  
Short Hairpin Rna ◽  
Prolyl Hydroxylase ◽  
Hindlimb Ischemia ◽  
Hairpin Rna ◽  
Short Hairpin

scholarly journals Are Viral Vectors Any Good for RNAi Antiviral Therapy?

Viruses ◽  
2020 ◽  
Vol 12 (10) ◽  
pp. 1189
Author(s):  
Kenneth Lundstrom
Keyword(s):  
Hepatitis B Virus ◽  
Hepatitis B ◽  
Gene Silencing ◽  
Antiviral Therapy ◽  
Virus Replication ◽  
Viral Vectors ◽  
Short Hairpin Rna ◽  
Hairpin Rna ◽  
B Virus ◽  
Short Hairpin

RNA interference (RNAi) represents a novel approach for alternative antiviral therapy. However, issues related to RNA delivery and stability have presented serious obstacles for obtaining good therapeutic efficacy. Viral vectors are capable of efficient delivery of RNAi as short interfering RNA (siRNA), short hairpin RNA (shRNA) and micro-RNA (miRNA). Efficacy in gene silencing for therapeutic applications against viral diseases has been demonstrated in various animal models. Rotavirus (RV) miR-7 can inhibit rotavirus replication by targeting the RV nonstructural protein 5. Viral gene silencing by targeting the RNAi pathway showed efficient suppression of hepatitis B virus replication by adeno-associated virus (AAV)-based delivery of RNAi hepatitis B virus (HBV) cassettes. Hepatitis C virus replication has been targeted by short hairpin RNA molecules expressed from lentivirus vectors. Potentially, RNAi-based approaches could be suitable for antiviral drugs against COVID-19.

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