scholarly journals Patellar bone marrow lesions predict patellar cartilage defect progression, cartilage volume loss and knee pain in older adults: a cohort study

2014 ◽  
Vol 22 ◽  
pp. S185 ◽  
Author(s):  
J. Wang ◽  
B. Antony ◽  
W. Han ◽  
Z. Liu ◽  
F. Pan ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Marrow ◽  
Cohort Study ◽  
Knee Pain ◽  
Cartilage Defect ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Bone Marrow Lesions ◽  
Patellar Cartilage ◽  
Cartilage Volume Loss

scholarly journals Bone marrow lesions predict site-specific cartilage defect development and volume loss: a prospective study in older adults

2010 ◽  
Vol 12 (6) ◽  
Author(s):  
Dawn Dore ◽  
Ashleigh Martens ◽  
Stephen Quinn ◽  
Changhai Ding ◽  
Tania Winzenberg ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Marrow ◽  
Prospective Study ◽  
Cartilage Defect ◽  
Volume Loss ◽  
Site Specific ◽  
Bone Marrow Lesions ◽  
A Prospective Study

scholarly journals Association between patella alta and changes in cartilage volume, cartilage defects and bone marrow lesions in older adults: a cohort study

2014 ◽  
Vol 22 ◽  
pp. S89-S90
Author(s):  
F. Pan ◽  
W. Han ◽  
X. Wang ◽  
B. Antony ◽  
X. Jin ◽  
...  
Keyword(s):  
Older Adults ◽  
Bone Marrow ◽  
Cohort Study ◽  
Cartilage Volume ◽  
Patella Alta ◽  
Cartilage Defects ◽  
Bone Marrow Lesions

scholarly journals Effect of chondroitin sulfate on cartilage volume loss and subchondral bone marrow lesions in osteoarthritis knee

2015 ◽  
Vol 42 (3) ◽  
pp. 153 ◽  
Author(s):  
MohammadA Zakaria ◽  
HadeerS Fahmy ◽  
AnwarA Shalaby ◽  
MohammadH Elgawish
Keyword(s):  
Bone Marrow ◽  
Chondroitin Sulfate ◽  
Subchondral Bone ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Bone Marrow Lesions ◽  
Osteoarthritis Knee ◽  
Cartilage Volume Loss

OP0138 Pain at Multiple Sites Outside the Knee Predicts Knee Cartilage Volume Loss: A Prospective Study in Older Adults

2015 ◽  
Vol 74 (Suppl 2) ◽  
pp. 121.1-121
Author(s):  
F. Pan ◽  
C. Ding ◽  
L.L. Laslett ◽  
J. Tian ◽  
T. Winzenberg ◽  
...  
Keyword(s):  
Older Adults ◽  
Prospective Study ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Knee Cartilage ◽  
A Prospective Study ◽  
Cartilage Volume Loss

scholarly journals Bone marrow lesions predict progression of cartilage defects and loss of cartilage volume in healthy middle-aged adults without knee pain over 2 yrs

Rheumatology ◽  
2008 ◽  
Vol 47 (9) ◽  
pp. 1392-1396 ◽  
Author(s):  
A. E. Wluka ◽  
Y. Wang ◽  
M. Davies-Tuck ◽  
D. R. English ◽  
G. G. Giles ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Knee Pain ◽  
Cartilage Volume ◽  
Cartilage Defects ◽  
Middle Aged ◽  
Bone Marrow Lesions ◽  
Middle Aged Adults

scholarly journals Chondroitin sulphate reduces both cartilage volume loss and bone marrow lesions in knee osteoarthritis patients starting as early as 6 months after initiation of therapy: a randomised, double-blind, placebo-controlled pilot study using MRI

2011 ◽  
Vol 70 (6) ◽  
pp. 982-989 ◽  
Author(s):  
Lukas Martin Wildi ◽  
Jean-Pierre Raynauld ◽  
Johanne Martel-Pelletier ◽  
André Beaulieu ◽  
Louis Bessette ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Chondroitin Sulphate ◽  
Lateral Compartment ◽  
Cartilage Volume ◽  
Volume Loss ◽  
Double Blind ◽  
Once Daily ◽  
Disease Symptoms ◽  
Knee Oa ◽  
Cartilage Volume Loss

ObjectiveTo determine the effect of chondroitin sulphate (CS) treatment on cartilage volume loss, subchondral bone marrow lesions (BML), synovitis and disease symptoms in patients with knee osteoarthritis (OA).MethodsIn this pilot multicentre, randomised, double-blind, controlled trial in primary knee OA, 69 patients with clinical signs of synovitis were randomised to receive CS 800 mg or placebo once daily for 6 months followed by an open-label phase of 6 months in which patients in both groups received CS 800 mg once daily. Cartilage volume and BML were assessed by MRI at baseline and at 6 and 12 months; synovial membrane thickness was assessed at baseline and at 6 months.ResultsThe CS group showed significantly less cartilage volume loss than the placebo group as early as 6 months for the global knee (p=0.030), lateral compartment (p=0.015) and tibial plateaus (p=0.002), with significance persisting at 12 months. Significantly lower BML scores were found for the CS group at 12 months in the lateral compartment (p=0.035) and the lateral femoral condyle (p=0.044). Disease symptoms were similar between the two groups.ConclusionCS treatment significantly reduced the cartilage volume loss in knee OA starting at 6 months of treatment, and BML at 12 months. These findings suggest a joint structure protective effect of CS and provide new in vivo information on its mode of action in knee OA.

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