scholarly journals Preliminary results from a phase 1b double-blind study to assess the safety, tolerability and efficacy of intra-articular administration of resiniferatoxin or placebo for the treatment of moderate to severe pain due to osteoarthritis of the knee

2020 ◽  
Vol 28 ◽  
pp. S138
Author(s):  
D. Leiman ◽  
H. Minkowitz ◽  
R.C. Levitt ◽  
D. Solanki ◽  
D. Horn ◽  
...  
Keyword(s):  
Severe Pain ◽  
Blind Study ◽  
Osteoarthritis Of The Knee ◽  
Double Blind Study ◽  
Double Blind ◽  
Preliminary Results ◽  
Phase 1B

scholarly journals Peritonsillar Infiltration with Bupivacaine for Paediatric Tonsillectomy

1994 ◽  
Vol 22 (6) ◽  
pp. 679-682 ◽  
Author(s):  
J. C. Stuart ◽  
F. B. Macgregor ◽  
C. S. Cairns ◽  
H. R. Chandrachud
Keyword(s):  
Pain Score ◽  
Severe Pain ◽  
Blind Study ◽  
Double Blind Study ◽  
Double Blind ◽  
Peritonsillar Infiltration ◽  
Induction Of Anaesthesia ◽  
To Receive

In a double-blind study forty-two children scheduled for elective adenotonsillectomy were randomized to receive peritonsillar infiltration, following induction of anaesthesia, with either 0.25% plain bupivacaine or 0.9% saline, 0.5 ml/kg to a maximum of 10 ml. The children were assessed on awakening, and then 10 minutes, 1 hour, 4 hours and 24 hours later. On each occasion the observer gave the child a pain score from 1 (no pain) to 5 (severe pain). The scores on awakening and after 10 minutes were significantly lower in the bupivacaine group (P< 0.05, Mann-Whitney U test). Thereafter there was no difference between the groups. The authors conclude that peritonsillar infiltration with bupivacaine is only moderately useful as analgesia for children having tonsillectomy.

Intra-articular sodium hyaluronate in osteoarthritis of the knee: a multicenter, double-blind study

1993 ◽  
Vol 1 (4) ◽  
pp. 233-241 ◽  
Author(s):  
W PUHL ◽  
A BERNAU ◽  
H GREILING ◽  
W KOPCKE ◽  
W PFORRINGER ◽  
...  
Keyword(s):  
Sodium Hyaluronate ◽  
Blind Study ◽  
Osteoarthritis Of The Knee ◽  
Double Blind Study ◽  
Double Blind
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