Presence of Myofibroblasts and Matrix Metalloproteinase 2 in Radicular Cysts, Dentigerous Cysts, and Keratocystic Odontogenic Tumors: A Comparative Immunohistochemical Study

2012 ◽  
Vol 38 (10) ◽  
pp. 1363-1367 ◽  
Author(s):  
Michele Regina Nadalin ◽  
Eduardo Rodrigues Fregnani ◽  
Yara Teresinha Correa Silva-Sousa ◽  
Danyel Elias da Cruz Perez
Keyword(s):  
Matrix Metalloproteinase ◽  
Immunohistochemical Study ◽  
Odontogenic Tumors ◽  
Matrix Metalloproteinase 2 ◽  
Dentigerous Cysts ◽  
Keratocystic Odontogenic Tumors

scholarly journals Matrix metalloproteinase expression in keratocystic odontogenic tumors and primary cells

2014 ◽  
Vol 55 (sup1) ◽  
pp. 97-101 ◽  
Author(s):  
Hope M. Amm ◽  
Monee D. Casimir ◽  
Dakota B. Clark ◽  
Phillip Sohn ◽  
Mary MacDougall
Keyword(s):  
Matrix Metalloproteinase ◽  
Odontogenic Tumors ◽  
Primary Cells ◽  
Keratocystic Odontogenic Tumors

scholarly journals Odontogenic Epithelium: Immunolabeling of Ki-67, EGFR and Survivin in Pericoronal Follicles, Dentigerous Cysts and Keratocystic Odontogenic Tumors

2010 ◽  
Vol 5 (1) ◽  
pp. 1-7 ◽  
Author(s):  
Márcia Gaiger de Oliveira ◽  
Isabel da Silva Lauxen ◽  
Anna Cecília Moraes Chaves ◽  
Pantelis Varvaki Rados ◽  
Manoel Sant’Ana Filho
Keyword(s):  
Odontogenic Tumors ◽  
Ki 67 ◽  
Odontogenic Epithelium ◽  
Dentigerous Cysts ◽  
Keratocystic Odontogenic Tumors

Evaluation of mast cells in periapical cysts, dentigerous cysts, and keratocystic odontogenic tumors

2012 ◽  
Vol 41 (8) ◽  
pp. 630-636 ◽  
Author(s):  
Juliana de Noronha Santos Netto ◽  
Fábio Ramôa Pires ◽  
Eliene Carvalho da Fonseca ◽  
Licínio Esmeraldo Silva ◽  
Simone de Queiroz Chaves Lourenço
Keyword(s):  
Mast Cells ◽  
Odontogenic Tumors ◽  
Dentigerous Cysts ◽  
Keratocystic Odontogenic Tumors

scholarly journals Correlation Between Radiographic Area and Immunolocation of MMP-2 and MMP-9 in Unilocular Radiographic Lesions

2014 ◽  
Vol 25 (6) ◽  
pp. 466-471
Author(s):  
Rafaela Scariot ◽  
Lucas Caetano Uetanabaro ◽  
Melissa Rodrigues de Araujo ◽  
Joao Zielak ◽  
Allan Fernando Giovanini ◽  
...  
Keyword(s):  
Immunohistochemical Analysis ◽  
Biological Behavior ◽  
Odontogenic Tumors ◽  
Inverse Association ◽  
Bone Cysts ◽  
Maxillofacial Region ◽  
Pathological Conditions ◽  
Dentigerous Cysts ◽  
Ellipse Area ◽  
Keratocystic Odontogenic Tumors

Unilocular bone cysts are the most common entities affecting the maxillofacial region. The mechanism of proliferation and expansion remains unclear. Metalloproteinases (MMPs) are associated to diverse pathological conditions. The aim of the present study was to correlate the radiographic aspect (area) and the presence of MMP-2 and MMP-9 in dentigerous cysts, radicular cysts and keratocystic odontogenic tumors. The radiographic area of each lesion was calculated using the mathematical formula of the ellipse area. All specimens were subjected to immunohistochemical analysis for these enzymes. The average radiographic area was 284.17 mm2, 235.81 mm2 and 381.81 mm2, respectively. Statistical analyses revealed no association between the immunoreactivity of MMPs and radiographic area of the lesions in all pathologies studied, except for MMP-2 and radicular cysts, for which smaller lesions had increased immunostaining for this enzyme. The results demonstrate that quantities of MMP-2 and MMP-9 are especially involved with dentigerous and radicular cysts in expansion, whereas these enzymes seem to be related to the biological behavior of keratocystic odontogenic tumors, indicating invasion and cell proliferation. Moreover, there is an inverse association between MMP-2 and MMP-9 in keratocystic odontogenic tumors (p=0.03; rs=-0.660), indicating activity in different regions.

scholarly journals Histopathological and immunohistochemical study in keratocystic odontogenic tumors: Predictive factors of recurrence

2017 ◽  
Vol 13 (5) ◽  
pp. 3487-3493 ◽  
Author(s):  
Tomofumi Naruse ◽  
Kentaro Yamashita ◽  
Souichi Yanamoto ◽  
Satoshi Rokutanda ◽  
Yuki Matsushita ◽  
...  
Keyword(s):  
Predictive Factors ◽  
Immunohistochemical Study ◽  
Odontogenic Tumors ◽  
Keratocystic Odontogenic Tumors

scholarly journals Comparison of osteoclastogenesis and local invasiveness of ameloblastoma and keratocystic odontogenic tumor

2018 ◽  
Vol 12 (01) ◽  
pp. 036-042
Author(s):  
Natheer H. Al-Rawi ◽  
Ammar K. Al-Siraj ◽  
Ahlam H. Majeed
Keyword(s):  
Matrix Metalloproteinase ◽  
Stromal Cells ◽  
Nuclear Factor Kappa B ◽  
The Other ◽  
Matrix Metalloproteinase 2 ◽  
Keratocystic Odontogenic Tumor ◽  
Nuclear Factor ◽  
Significant Expression ◽  
Type Ab ◽  
Keratocystic Odontogenic Tumors

Abstract: Objectives The aim of this study was to compare the expression of receptor-activated nuclear factor kappa B (RANK) with its ligand (RANKL) and matrix metalloproteinase-2 (MMP2) in solid/multicystic ameloblastomas (ABs) and keratocystic odontogenic tumors (KOTs). Materials and Methods: The expression of MMP2, RANK, and RANKL molecules was evaluated in 13 ABs and 14 KOTs by immunohistochemistry. The expressions were calculated in the odontogenic epithelial cells as well as the stromal cells. Results: Odontogenic epithelia of AB expressed MMP2, RANK, and RANKL significantly higher than that of KOTs (P < 0.05). The expression of MMP2, RANK, and RANKL was highest in plexiform subtype (79.9%, 81.08%, and 65.1%, respectively). KOTs without daughter epithelia nests expressed both MMP2 and RANK the least (56.06% and 47.5%, respectively). Stromal cells, on the other hand, expressed similar MMP2 pattern in odontogenic epithelia of both AB and KOT. RANKL was expressed weaker in the stromal cells of both lesions. Conclusion: Invasive biological and osteolytic behaviors of both lesions were evaluated in this study. It was found to be more in AB than keratocystic odontogenic. A significant expression of MMP2, RANK, and RANKL in both KOTs associated with microcyst and plexiform type AB as well.

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