Aggressive Central Giant Cell Granuloma of the Mandible Treated With Conservative Surgical Enucleation and Interferon–α-2a: Complete Remission With Long-Term Follow-Up

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

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Central giant cell granuloma of the maxilla: Long‐term follow‐up of a patient treated with an adjuvant corticosteroid

Special Care in Dentistry ◽

10.1111/scd.12569 ◽

2021 ◽

Author(s):

José Alcides Almeida de Arruda ◽

Allisson Filipe Lopes Martins ◽

Lucas Guimarães Abreu ◽

Ricardo Alves Mesquita ◽

Sandra Ventorin von Zeidler ◽

...

Keyword(s):

Giant Cell ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Long Term Follow Up

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Correction to: Central Giant Cell Granuloma Treated with Intralesional Corticosteroid Injections and Bisphosphonates: A Long‑Term Follow‑Up Case Study

Head and Neck Pathology ◽

10.1007/s12105-021-01357-x ◽

2021 ◽

Author(s):

Raíssa Pinheiro de Mendonça ◽

Geovanni Pereira Mitre ◽

Flavio Henrique Real ◽

Maria Sueli da Silva Kataoka ◽

Sérgio de Melo Alves Júnior ◽

...

Keyword(s):

Giant Cell ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Intralesional Corticosteroid ◽

Long Term Follow Up ◽

Corticosteroid Injections

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The importance of a long-term follow up: central giant cell granuloma in a child under conservative treatment and a full lesion repair after 6 years

Oral Surgery Oral Medicine Oral Pathology and Oral Radiology ◽

10.1016/j.oooo.2012.08.094 ◽

2012 ◽

Vol 114 (4) ◽

pp. e62

Keyword(s):

Conservative Treatment ◽

Giant Cell ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Long Term Follow Up

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A Case of Giant Cell Granuloma of Maxillary Sinus: Long-Term Follow-Up

Korean Journal of Otolaryngology - Head and Neck Surgery ◽

10.3342/kjorl-hns.2009.52.3.284 ◽

2009 ◽

Vol 52 (3) ◽

pp. 284 ◽

Cited By ~ 1

Author(s):

Hyeong-Jun Jang ◽

Se-Joon Oh ◽

Kyu-Sup Cho ◽

Hwan-Jung Roh

Keyword(s):

Maxillary Sinus ◽

Giant Cell ◽

Giant Cell Granuloma ◽

Long Term Follow Up

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A UNIQUE CASE REPORT OF AGGRESSIVE CENTRAL GIANT CELL GRANULOMA OF THE MANDIBLE TREATED WITH CONSERVATIVE SURGICAL ENUCLEATION WITH LONG TERM FOLLOW-UP

Clinical Dentistry ◽

10.33882/clinicaldent.13.25366 ◽

2019 ◽

Author(s):

Gourab Das ◽

Bharat Shukla ◽

Dhritiman Pathak ◽

Abhishek Singh ◽

Shailesh Kumar

Keyword(s):

Giant Cell ◽

Giant Cells ◽

Giant Cell Granuloma ◽

Central Giant Cell Granuloma ◽

Woven Bone ◽

Long Term Follow Up ◽

Benign Tumours ◽

Bone Trabeculae ◽

Surgical Aspects

Central Giant Cell Granuloma (CGCG) is an intrabony lesion showing cellular fibrosis with numerous foci of haemorrhage, woven bone trabeculae and multinucleated giant cells. It is more commonly found in the mandible than maxilla. Among all benign tumours of jaw, it accounts for less than 7%. According to the reports, in approximately 48% cases, it is diagnosed in the first two decades of life and in almost 60% cases, before 30 years of age. This paper presents a case of CGCG involving the mandibular left anterior region of a female patient with clinical, radiological, histopathological and surgical aspects of the lesion. Key Words- Central Giant Cell Granuloma (CGCG), CONSERVATIVE SURGICAL ENUCLEATION

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Long-term follow-up of differentiated thyroid carcinoma in children and adolescents

Journal of Pediatric Endocrinology and Metabolism ◽

10.1515/jpem-2020-0194 ◽

2020 ◽

Vol 33 (11) ◽

pp. 1431-1441

Author(s):

Montserrat Negre Busó ◽

Amparo García Burillo ◽

Marc Simó Perdigó ◽

Pere Galofré Mora ◽

Maria Boronat de Ferrater ◽

...

Keyword(s):

Complete Remission ◽

Thyroid Carcinoma ◽

Children And Adolescents ◽

Differentiated Thyroid Carcinoma ◽

Radioiodine Treatment ◽

Persistent Disease ◽

Stage 4 ◽

Long Term Follow Up

AbstractObjectivesThe aims were to analyze the clinical features, response to treatment, prognostic factors and long-term follow-up of children and adolescents with differentiated thyroid carcinoma (DTC).MethodsEighty patients with DTC were studied retrospectively. All underwent total or near-total thyroidectomy, and in 75 cases, ablative iodine therapy was recommended. Patients were assessed periodically by tests for serum thyroglobulin levels and whole-body iodine scans. Age, gender, initial clinical presentation, histology, tumor stage, postoperative complications, radioiodine treatment protocol, treatment response, thyroglobulin (Tg), recurrence and long-term disease progression were evaluated.ResultsSeventy patients completed >2 years of follow-up (23 males, 47 females; median age: 14 years; range: 3–18 years). Sixty-two patients showed papillary DTC and eight, follicular DTC. Sixty-five percent presented nodal metastasis and 16%, pulmonary metastasis at diagnosis. Six months after first radioiodine treatment, 36.2% of patients were free of disease. Seven recurrences were documented. At the end of follow-up, overall survival was 100%, and 87.2% of patients were in complete remission. Nine patients had persistent disease. We found a significant association between stage 4 and persistent disease. Hundred percent of patients with negative Tg values at 6 months posttreatment were documented free of disease at the end of the follow-up. The analysis of disease-free survival based on radioiodine treatment protocols used showed no statistically significant differences.ConclusionsDTC in children and adolescents is frequently associated with presence of advanced disease at diagnosis. Despite this, complete remission was documented after treatment in most cases, with a good prognosis in the long-term follow-up. Negative posttreatment thyroglobulin and stage 4 at diagnosis were significant prognostic variables.

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