Large Treatment Effect With Extended Home-Based Transcranial Direct Current Stimulation Over Dorsolateral Prefrontal Cortex in Fibromyalgia: A Proof of Concept Sham-Randomized Clinical Study

2020 ◽  
Vol 21 (1-2) ◽  
pp. 212-224 ◽  
Author(s):  
Aline P. Brietzke ◽  
Maxciel Zortea ◽  
Fabiana Carvalho ◽  
Paulo R.S. Sanches ◽  
Danton P. Jr. Silva ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Clinical Study ◽  
Direct Current ◽  
Treatment Effect ◽  
Dorsolateral Prefrontal Cortex ◽  
Proof Of Concept ◽  
Randomized Clinical Study ◽  
Home Based ◽  
Dorsolateral Prefrontal ◽  
Large Treatment Effect

Comparing the effects of multi-session anodal trans-cranial direct current stimulation of primary motor and dorsolateral prefrontal cortices on fatigue and quality of life in patients with multiple sclerosis: a double-blind, randomized, sham-controlled trial

2020 ◽  
Vol 34 (8) ◽  
pp. 1103-1111
Author(s):  
Marzieh Mortezanejad ◽  
Fatemeh Ehsani ◽  
Nooshin Masoudian ◽  
Maryam Zoghi ◽  
Shapour Jaberzadeh
Keyword(s):  
Quality Of Life ◽  
Multiple Sclerosis ◽  
Prefrontal Cortex ◽  
Direct Current ◽  
Dorsolateral Prefrontal Cortex ◽  
Fatigue Severity Scale ◽  
Severity Scale ◽  
Dorsolateral Prefrontal ◽  
Fatigue Severity

Objective: To compare the effects of anodal trans-cranial direct current stimulation (a-tDCS) over primary motor and dorsolateral prefrontal cortices on Fatigue Severity Scale and its lasting effect on fatigue reduction and improvement in quality of life in patients with multiple sclerosis. Design: A randomized, double-blinded, sham-controlled parallel clinical trial study. Setting: Neurological physiotherapy clinics. Subjects: Thirty-nine participants were randomly assigned to three groups: dorsolateral prefrontal cortex a-tDCS, primary motor a-tDCS (experimental groups) and sham a-tDCS. Finally, 36 participants completed the whole study ( n = 12 in each group). Interventions: Participants in the experimental groups received six-session a-tDCS (1.5 mA, 20 minutes) during two weeks (three sessions per week). The sham group received six sessions of 20-minute sham stimulation. Main measures: The Fatigue Severity Scale and quality of life were assessed before, immediately and four weeks after the intervention. Results: Findings indicated a significant reduction in the Fatigue Severity Scale and a significant increase in the quality of life in both experimental groups, immediately after the intervention ( P < 0.001), while Fatigue Severity Scale and quality of life changes were not significant in the sham a-tDCS group ( P > 0.05). In addition, improvement of the variables remained four weeks after the intervention in dorsolateral prefrontal cortex a-tDCS (mean differences (95% confidence interval): 0.03 (−0.63 to 0.68) as compared to primary motor (−0.62 (−0.11 to −1.14) and sham a-tDCS groups (−0.47 (−1.37 to 0.43)). Conclusion: Both primary motor and dorsolateral prefrontal cortex a-tDCS as compared to sham intervention can immediately improve fatigue and quality of life. However, the effects last up to four weeks only by the dorsolateral prefrontal cortex a-tDCS.

scholarly journals Influence of Transcranial Direct Current Stimulation on Psychomotor Symptoms in Major Depression

2020 ◽  
Vol 10 (11) ◽  
pp. 792
Author(s):  
Djamila Bennabi ◽  
Nicolas Carvalho ◽  
Ambra Bisio ◽  
Juliana Teti Mayer ◽  
Thierry Pozzo ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Dorsolateral Prefrontal Cortex ◽  
Rating Scale ◽  
Small Sample ◽  
Psychomotor Activity ◽  
Direct Current Stimulation ◽  
Depressed Patients ◽  
Dorsolateral Prefrontal

Background: Transcranial direct current stimulation (tDCS) applied to the left dorsolateral prefrontal cortex (dlPFC) might be a promising treatment strategy for depression. As disturbances in psychomotor activity are one of the key features of unipolar depression are, we aimed to evaluate the behavioral effects of ten tDCS sessions over a 5-day period on psychomotor retardation in depressed patients. Methods: Twenty-three treatment-resistant depressed patients received either active or sham anodal tDCS to the left dorsolateral prefrontal cortex (2 mA, 10 sessions over 1 week). Psychomotor functioning was registered by means of observer ratings (Salpêtrière Retardation Rating Scale—SRRS) and objective measures (kinematical analysis of movements, automatic imitation). Results: tDCS sessions resulted in improvements on SRRS scores, although active tDCS was not significantly superior to sham tDCS on the kinematical parameters. Furthermore, no general additional antidepressant effect of tDCS was observed. The relatively small sample size and the short periods of observation should be considered when interpreting these results. Conclusion: tDCS did not induce a clinically relevant effect on psychomotor function in active and sham stimulation groups.

scholarly journals Verbal Fluency in Mild Alzheimer’s Disease: Transcranial Direct Current Stimulation over the Dorsolateral Prefrontal Cortex

2021 ◽  
pp. 1-11
Author(s):  
Daniela Smirni ◽  
Massimiliano Oliveri ◽  
Eliana Misuraca ◽  
Angela Catania ◽  
Laura Vernuccio ◽  
...  
Keyword(s):  
Prefrontal Cortex ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Verbal Fluency ◽  
Dorsolateral Prefrontal Cortex ◽  
Control Group ◽  
Direct Current Stimulation ◽  
Cathodal Tdcs ◽  
Dorsolateral Prefrontal ◽  
The Right

Background: Recent studies showed that in healthy controls and in aphasic patients, inhibitory trains of repetitive transcranial magnetic stimulation (rTMS) over the right prefrontal cortex can improve phonemic fluency performance, while anodal transcranial direct current stimulation (tDCS) over the left prefrontal cortex can improve performance in naming and semantic fluency tasks. Objective: This study aimed at investigating the effects of cathodal tDCS over the left or the right dorsolateral prefrontal cortex (DLPFC) on verbal fluency tasks (VFT) in patients with mild Alzheimer’s disease (AD). Methods: Forty mild AD patients participated in the study (mean age 73.17±5.61 years). All participants underwent cognitive baseline tasks and a VFT twice. Twenty patients randomly received cathodal tDCS to the left or the right DLPFC, and twenty patients were assigned to a control group in which only the two measures of VFT were taken, without the administration of the tDCS. Results: A significant improvement of performance on the VFT in AD patients was present after tDCS over the right DLPFC (p = 0.001). Instead, no difference was detected between the two VFTs sessions after tDCS over the left DLPFC (p = 0.42). Furthermore, these results cannot be related to task learning effects, since no significant difference was found between the two VFT sessions in the control group (p = 0.73). Conclusion: These data suggest that tDCS over DLPFC can improve VFT performance in AD patients. A hypothesis is that tDCS enhances adaptive patterns of brain activity between functionally connected areas.

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