Integration of liquid chromatography mass spectrometry with a heavy peptide response curve accurately measures unprocessed C-terminal lysine during peptide mapping analysis of therapeutic antibodies in a single run

Mapping Analysis

From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies

10.1016/j.chroma.2019.460740 ◽

2020 ◽

Vol 1615 ◽

pp. 460740 ◽

Cited By ~ 8

Author(s):

Alexandre Goyon ◽

Lu Dai ◽

Tao Chen ◽

Bingchuan Wei ◽

Feng Yang ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Therapeutic Antibodies ◽

Proof Of Concept ◽

Fast and efficient digestion of adeno associated virus (AAV) capsid proteins for liquid chromatography mass spectrometry (LC-MS) based peptide mapping and post translational modification analysis (PTMs)

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2021.114427 ◽

2021 ◽

pp. 114427

Author(s):

Felipe Guapo ◽

Lisa Strasser ◽

Silvia Millán-Martín ◽

Ian Anderson ◽

Jonathan Bones

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Peptide Mapping ◽

Capsid Proteins ◽

Post Translational Modification ◽

Adeno Associated Virus ◽

Enhanced sensitivity for peptide mapping with electrospray liquid chromatography-mass spectrometry in the presence of signal suppression due to trifluoroacetic acid-containing mobile phases

10.1016/0021-9673(95)00175-m ◽

1995 ◽

Vol 712 (1) ◽

pp. 177-190 ◽

Cited By ~ 251

Author(s):

Alex Apffel ◽

Steven Fischer ◽

Gerson Goldberg ◽

Paul C. Goodley ◽

Frank E. Kuhlmann

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Trifluoroacetic Acid ◽

Peptide Mapping ◽

Enhanced Sensitivity ◽

Signal Suppression ◽

Mobile Phases

Development of Comprehensive Online Two-Dimensional Liquid Chromatography/Mass Spectrometry Using Hydrophilic Interaction and Reversed-Phase Separations for Rapid and Deep Profiling of Therapeutic Antibodies

Analytical Chemistry ◽

10.1021/acs.analchem.8b00776 ◽

2018 ◽

Vol 90 (9) ◽

pp. 5923-5929 ◽

Cited By ~ 36

Author(s):

Dwight R. Stoll ◽

David C. Harmes ◽

Gregory O. Staples ◽

Oscar G. Potter ◽

Carston T. Dammann ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Reversed Phase ◽

Two Dimensional ◽

Therapeutic Antibodies ◽

Hydrophilic Interaction ◽

Phase Separations ◽

Analysis of core histones by liquid chromatography–mass spectrometry and peptide mapping

Journal of Chromatography B ◽

10.1016/s1570-0232(02)00631-1 ◽

2003 ◽

Vol 783 (1) ◽

pp. 173-179 ◽

Cited By ~ 29

Author(s):

Kangling Zhang ◽

Hui Tang

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Peptide Mapping ◽

Core Histones

Multi-Attribute Monitoring of Complex Erythropoetin Beta Glycosylation by GluC Liquid Chromatography–Mass Spectrometry Peptide Mapping

Analytical Chemistry ◽

10.1021/acs.analchem.0c00124 ◽

2020 ◽

Vol 92 (11) ◽

pp. 7574-7580 ◽

Cited By ~ 2

Author(s):

Alexander Buettner ◽

Maria Maier ◽

Lea Bonnington ◽

Patrick Bulau ◽

Dietmar Reusch

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Peptide Mapping ◽

Fully Automated Peptide Mapping Multi-Attribute Method by Liquid Chromatography–Mass Spectrometry with Robotic Liquid Handling System

Journal of Pharmaceutical and Biomedical Analysis ◽

10.1016/j.jpba.2021.113988 ◽

2021 ◽

pp. 113988

Author(s):

Chen Qian ◽

Ben Niu ◽

Rod Brian Jimenez ◽

Jihong Wang ◽

Methal Albarghouthi

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Peptide Mapping ◽

Handling System ◽

Liquid Handling ◽

Rapid high-sensitivity peptide mapping by liquid chromatography—mass spectrometry

10.1016/s0021-9673(99)87018-6 ◽

1993 ◽

Vol 646 (1) ◽

pp. 169-174 ◽

Cited By ~ 18

Author(s):

Kuldip Mock ◽

Mark Hail ◽

Iain Mylchreest ◽

Joe Zhou ◽

Ken Johnson ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Peptide Mapping ◽

High Sensitivity ◽

Bioanalytical Quantification of Therapeutic Antibodies by Liquid Chromatography/mass Spectrometry

Chromatography ◽

10.15583/jpchrom.2017.018 ◽

2018 ◽

Vol 39 (1) ◽

pp. 7-19 ◽

Cited By ~ 1

Author(s):

Noritaka HASHII ◽

Masahiro UTOH ◽

Yoshiaki OHTSU ◽

Nozomu KATO ◽

Ryoya GODA ◽

...

Keyword(s):

Mass Spectrometry ◽

Liquid Chromatography ◽

Therapeutic Antibodies ◽

Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography–mass spectrometry peptide mapping

10.1016/j.chroma.2011.08.089 ◽

2011 ◽

Vol 1218 (45) ◽

pp. 8140-8149 ◽

Cited By ~ 33

Author(s):

Jacob Bongers ◽

John Devincentis ◽

Jinmei Fu ◽

Peiqing Huang ◽

David H. Kirkley ◽

...

Keyword(s):

Mass Spectrometry ◽

Monoclonal Antibody ◽

Liquid Chromatography ◽

Fusion Protein ◽

Peptide Mapping ◽

Glycosylation Sites ◽

Igg1 Monoclonal Antibody