An Infant with Pulmonary-Cutaneous Sweet Syndrome

Non-neuropathic ulcers in leprosy patients are infrequently seen, and atypical presentations are prone to misdiagnosis. We evaluated diagnosed cases of leprosy between January 2017 and January 2020 for the presence of cutaneous ulceration, Ridley–Jopling subtype of leprosy, reactions and histologic features of these ulcerations. Treatment was given as WHO recommended multi-bacillary multi-drug therapy. We found 17/386 leprosy patients with non-neuropathic ulcers. We describe three causes – spontaneous cutaneous ulceration in lepromatous leprosy (one nodular and one diffuse), lepra reactions (five patients with type 1; nine with type 2, further categorised into ulcerated Sweet syndrome-like who also had pseudoepitheliomatous hyperplasia, pustulo-necrotic and necrotic erythema nodosum leprosum) and Lucio phenomenon (one patient). Our series draws attention towards the different faces of non-neuropathic ulcers in leprosy, including some atypical and novel presentations.

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Sweet Syndrome and Secondary Syphilis in a Person with Acute Necrotizing Tonsillitis

Case Reports in Dermatology ◽

10.1159/000509374 ◽

2021 ◽

Vol 13 (1) ◽

pp. 216-221

Author(s):

Joseph Mishal ◽

Igor Viner ◽

Alexandro Livoff ◽

Shlomo Maayan ◽

Eli Magen

Keyword(s):

Unusual Case ◽

Treponema Pallidum ◽

Cervical Lymphadenopathy ◽

Secondary Syphilis ◽

Neutrophilic Dermatosis ◽

Sweet Syndrome ◽

Acute Febrile Neutrophilic Dermatosis ◽

Acute Necrotizing ◽

The Right ◽

Syphilis Serology

Syphilis has received its classical designation as one of “the great imitators,” reflecting a wide variety of symptoms and presentations, which can cause difficulties in diagnosis. Here we report an unusual case of secondary syphilis in a person with acute necrotizing tonsillitis and Sweet syndrome. A 33-year-old female presented with fever, bilateral cervical lymphadenopathy, tonsillar enlargements with ulcerated pus-filled lesions on the right tonsil, and multiple pseudovesicular, mammillated, edematous plaques on her neck, face, and extremities. Syphilis serology was positive and a skin biopsy demonstrated a neutrophil-rich dermatitis characteristic of Sweet syndrome. The association of <i>Treponema pallidum</i> infection with Sweet syndrome may be a coincidence; nevertheless, our case serves as a reminder that secondary syphilis should remain in the differential diagnosis of the acute febrile neutrophilic dermatosis.

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Sweet syndrome associated with malignancies: A retrospective analysis of 25 patients from West China hospital

Dermatologic Therapy ◽

10.1111/dth.13588 ◽

2020 ◽

Vol 33 (4) ◽

Author(s):

Hao Dan ◽

Li Yanmei ◽

Xiao Yue ◽

Jiang Xian

Keyword(s):

Retrospective Analysis ◽

West China Hospital ◽

Sweet Syndrome ◽

West China

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Generalized Sweet Syndrome Lesions Associated with Behçet Disease

American Journal of Clinical Dermatology ◽

10.2165/11310790-000000000-00000 ◽

2009 ◽

Vol 10 (5) ◽

pp. 331-335 ◽

Cited By ~ 10

Author(s):

Serap Köran Karadoğan ◽

Emel Bülbül Başkan ◽

Gülçin Alkan ◽

Hayriye Sarcaoğlu ◽

Şükran Tunal

Keyword(s):

Behçet Disease ◽

Behcet Disease ◽

Sweet Syndrome

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Necrotizing Sweet syndrome: A new variant of neutrophilic dermatosis mimicking necrotizing fasciitis

Journal of the American Academy of Dermatology ◽

10.1016/j.jaad.2012.02.024 ◽

2012 ◽

Vol 67 (5) ◽

pp. 945-954 ◽

Cited By ~ 36

Author(s):

Daniela Kroshinsky ◽

Allireza Alloo ◽

Brian Rothschild ◽

Jordan Cummins ◽

Jennifer Tan ◽

...

Keyword(s):

Necrotizing Fasciitis ◽

Neutrophilic Dermatosis ◽

Sweet Syndrome ◽

New Variant

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Sweet Syndrome in childhood

Anais Brasileiros de Dermatologia ◽

10.1590/abd1806-4841.20153247 ◽

2015 ◽

Vol 90 (4) ◽

pp. 567-569 ◽

Cited By ~ 4

Author(s):

Talita Batalha Pires dos Santos ◽

Barbara Cristina Gouveia Sales ◽

Marianne Sigres ◽

Fernando Rosman ◽

Ana Maria Mosca de Cerqueira

Keyword(s):

Sweet Syndrome

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Azathioprine hypersensitivity syndrome: report of two cases

BMJ Case Reports ◽

10.1136/bcr-2020-239099 ◽

2021 ◽

Vol 14 (5) ◽

pp. e239099

Author(s):

Tahlia McKenzie ◽

Shyam Dheda ◽

Murty Mantha ◽

Catherine Larsen

Keyword(s):

Antineutrophil Cytoplasmic Antibody ◽

Hypersensitivity Syndrome ◽

Severe Side Effect ◽

Dramatic Improvement ◽

Disease Relapse ◽

Serological Evidence ◽

Diagnostic Challenge ◽

Sweet Syndrome ◽

High Clinical Suspicion ◽

Syndrome Report

Azathioprine hypersensitivity syndrome is a rare but potentially severe side effect of azathioprine use. It has a variable and non-specific presentation making it difficult to distinguish from sepsis or disease relapse. High clinical suspicion is therefore required for recognition and prompt cessation of azathioprine for symptom resolution. Herewith two cases of severe azathioprine hypersensitivity syndrome are described, one in association with Sweet syndrome. Both presented with vague symptoms 2 weeks after commencing azathioprine for antineutrophil cytoplasmic antibody vasculitis. The differentials of sepsis and disease relapse were considered prior to cessation of azathioprine which resulted in a dramatic improvement in both cases. These cases highlight the diagnostic challenge azathioprine hypersensitivity syndrome presents. It should be suspected when there is a temporal relationship to drug initiation, with absence of infection or serological evidence of disease relapse.

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