Hydrocortisone and adult height in congenital adrenal hyperplasia

2014 ◽  
Vol 164 (5) ◽  
pp. 949-951
Author(s):  
Robert W. Wilmott
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Adrenal Hyperplasia

scholarly journals Final Adult Height in Children with Congenital Adrenal Hyperplasia Treated with Growth Hormone

2011 ◽  
Vol 96 (6) ◽  
pp. 1710-1717 ◽  
Author(s):  
Karen Lin-Su ◽  
Madeleine D. Harbison ◽  
Oksana Lekarev ◽  
Maria G. Vogiatzi ◽  
Maria I. New
Keyword(s):  
Growth Hormone ◽  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Adrenal Hyperplasia ◽  
Final Adult Height

Final Adult Height in Children with Congenital Adrenal Hyperplasia Treated with Growth Hormone

2011 ◽  
pp. P1-756-P1-756
Author(s):  
Karen Lin-Su ◽  
Madeleine D Harbison ◽  
Oksana Lekarev ◽  
Maria G Vogiatzi ◽  
Maria I New
Keyword(s):  
Growth Hormone ◽  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Adrenal Hyperplasia ◽  
Final Adult Height

Growth curves for congenital adrenal hyperplasia from a national retrospective cohort

2016 ◽  
Vol 29 (12) ◽  
Author(s):  
Patricia Bretones ◽  
Benjamin Riche ◽  
Emmanuel Pichot ◽  
Michel David ◽  
Pascal Roy ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Bone Age ◽  
Strong Impact ◽  
Adrenal Hyperplasia ◽  
Hydroxylase Deficiency ◽  
Bone Maturation ◽  
The Mean ◽  
Puberty Onset ◽  
21 Hydroxylase Deficiency

Abstract Background: In congenital adrenal hyperplasia (CAH), adjusting hydrocortisone dose during childhood avoids reduced adult height. However, there are currently no CAH-specific charts to monitor growth during treatment. Our objective was to elaborate growth reference charts and bone maturation data for CAH patients. Methods: We conducted a retrospective observational cohort study, in 34 French CAH centers. Patients were 496 children born 1970–1991 with genetically proven 21-hydroxylase deficiency. Their growth and bone maturation data were collected until age 18 together with adult height, puberty onset, parental height, and treatment. The mean (SD) heights were modeled from birth to adulthood. The median±1 SD and ±2 SDs model-generated curves were compared with the French references. A linear model for bone maturation and a logistic regression model for the probability of short adult height were built. Results: Growth charts were built by sex for salt wasting (SW) and simple virilizing (SV) children treated before 1 year of age. In girls and boys, growth was close to that of the general French population up to puberty onset. There was almost no pubertal spurt and the mean adult height was shorter than that of the general population in girls (−1.2 SD, 156.7 cm) and boys (−1.0 SD, 168.8 cm). Advanced bone age at 8 years had a strong impact on the risk of short adult height (OR: 4.5 per year advance). Conclusions: The 8-year bone age is a strong predictor of adult height. It will help monitoring the growth of CAH-affected children.

scholarly journals Adult Height in Patients with Congenital Adrenal Hyperplasia: A Systematic Review and Metaanalysis

2010 ◽  
Vol 95 (9) ◽  
pp. 4161-4172 ◽  
Author(s):  
Kalpana Muthusamy ◽  
Mohamed B. Elamin ◽  
Galina Smushkin ◽  
Mohammad Hassan Murad ◽  
Julianna F. Lampropulos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Adrenal Hyperplasia

scholarly journals Growth Trajectory and Adult Height in Children with Nonclassical Congenital Adrenal Hyperplasia

2020 ◽  
Vol 93 (3) ◽  
pp. 173-181
Author(s):  
Malgorzata Gabriela Wasniewska ◽  
Letteria Anna Morabito ◽  
Federico Baronio ◽  
Silvia Einaudi ◽  
Mariacarolina Salerno ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Growth Trajectory ◽  
Adrenal Hyperplasia

Final Adult Height in Children With Congenital Adrenal Hyperplasia Treated With Growth Hormone

2011 ◽  
Vol 66 (9) ◽  
pp. 552-554
Author(s):  
Karen Lin-Su ◽  
Madeleine D. Harbison ◽  
Oksana Lekarev ◽  
Maria G. Vogiatzi ◽  
Maria I. New
Keyword(s):  
Growth Hormone ◽  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Adrenal Hyperplasia ◽  
Final Adult Height

scholarly journals Novel Therapies for Treating Short Stature with Congenital Adrenal Hyperplasia

2011 ◽  
Vol 2 (2) ◽  
pp. 45-50
Author(s):  
Joe Leigh Simpson ◽  
Michael Christopher Hann ◽  
Anisha Kshetrapal ◽  
Maria I New
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Adult Height ◽  
Treatment Strategies ◽  
Gonadotropin Releasing Hormone ◽  
Novel Therapies ◽  
Adrenal Hyperplasia ◽  
Androgen Excess ◽  
Releasing Hormone ◽  
Salt Wasting ◽  
Hormone Analogs

ABSTRACT Congenital adrenal hyperplasia (CAH) is a group of autosomal recessive disorders in which various errors in adrenal biosynthesis pathways lead to impaired cortisol secretion, possible impairment of mineralocorticoid production and androgen excess. Glucocorticoid replacement therapy is the primary treatment for CAH; however, the combination of androgen excess and high doses of glucocorticoids contributes to shortened adult height. Novel approaches to address this problem are being developed, particularly the use of growth hormone (GH) and gonadotropin releasing hormone analogs (GnRHa). In this review, we document and compare the effectiveness of these novel therapies in ameliorating the decreased adult height observed in patients with CAH. Available data indicate effectiveness of these novel treatment strategies, suggesting widespread implementation of these treatment strategies should be tested with the expectation of being recommended as the standard of care. Abbreviations Congenital adrenal hyperplasia (CAH); Salt wasting (SW-CAH); Non-salt wasting (NSW-CAH); Growth hormone (GH); Gonadotropin releasing hormone analogs (GnRHa); Luteinizing hormone releasing hormone analog (LHRHa); 21-hydroxylase gene (CYP21); 21-hydroxylase pseudogene (CYP21p); Hypothalamic-pituitary-adrenal (HPA); Corticotropin-releasing hormone (CRH); Adrenocorticotropic hormone (ACTH); Bone mineral density (BMD); Standard score (SDS).

scholarly journals Histrelin Implantation and Growth Outcomes in Children With Congenital Adrenal Hyperplasia: An Institutional Experience

2019 ◽  
Vol 4 (2) ◽  
Author(s):  
Robert A Swendiman ◽  
Barbara E Coons ◽  
Craig A Alter ◽  
Vaneeta Bamba ◽  
Michael L Nance ◽  
...  
Keyword(s):  
Congenital Adrenal Hyperplasia ◽  
Precocious Puberty ◽  
Retrospective Cohort ◽  
Adult Height ◽  
Cohort Analysis ◽  
Bone Age ◽  
Adrenal Hyperplasia ◽  
Growth Data ◽  
Hydroxylase Deficiency ◽  
21 Hydroxylase Deficiency

Abstract Background Children with congenital adrenal hyperplasia (CAH) because of 21 hydroxylase deficiency (21OHD) are at risk for early or precocious puberty and a short adult height compared to population means and midparental height. The effect of histrelin in suppressing puberty and improving growth in these children has not been reported. Methods Retrospective cohort analysis of all patients (age ≤ 20) at our institution who underwent histrelin implantation between 2008 and 2017. Treated patients with CAH (classic and nonclassic forms of 21OHD) were identified and their growth data analyzed. Results Fifteen children with CAH were treated with histrelin for a median of 3 years (range 2–5; age at first implantation 7.7 ± 1.5 years). Bone age (BA) to chronologic age (CA) decreased from 1.57 ± 0.4 to 1.25 ± 0.25 (P < .01), while predicted adult height (PAH) increased by 7.1 ± 6.6 cm (P < .01). A subgroup of 10 children reached adult height. Similar changes in BA/CA and PAH were observed with therapy (P = .02). Adult height z improved compared to pretreatment PAH z (–1.42 ± 0.9 vs. –1.96 ± 1.1 respectively, P < .01), but remained lower than midparental height z (P = .01). Conclusion In this retrospective cohort study of children with CAH due to 21OHD and early or precocious puberty, histrelin implantation resulted in a decrease in BA progression compared to CA and an improvement in PAH. In the subgroup who completed growth, adult height remained significantly lower than midparental. These results need to be confirmed with prospective controlled studies.

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