Re: How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology Wilms tumor

2020 ◽  
Vol 55 (11) ◽  
pp. 2536
Author(s):  
Kiarash Taghavi
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Wilms Tumor ◽  
Lymph Node Yield ◽  
Favorable Histology ◽  
Node Yield

scholarly journals How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor

2019 ◽  
Vol 54 (11) ◽  
pp. 2331-2335 ◽  
Author(s):  
Amanda F. Saltzman ◽  
Derek E. Smith ◽  
Dexiang Gao ◽  
Debashis Ghosh ◽  
Arya Amini ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Wilms Tumor ◽  
Lymph Node Yield ◽  
Favorable Histology ◽  
Node Yield

Pathological analysis of lymph nodes in anterior prostatic fat excised at robot-assisted radical prostatectomy

2014 ◽  
Vol 67 (9) ◽  
pp. 787-791 ◽  
Author(s):  
J J Aning ◽  
R Thurairaja ◽  
D A Gillatt ◽  
A J Koupparis ◽  
E W Rowe ◽  
...  
Keyword(s):  
Lymph Node ◽  
Radical Prostatectomy ◽  
Lymph Nodes ◽  
Lymph Node Dissection ◽  
Node Dissection ◽  
Robot Assisted ◽  
Lymph Node Yield ◽  
Extended Lymph Node Dissection ◽  
Pathological Analysis ◽  
Node Yield

AimsTo assess the lymph node content of anterior prostatic fat (APF) sent routinely at robot-assisted laparoscopic radical prostatectomy (RALP) and the incidence of positive nodes in the extended pelvic lymph node dissection.MethodsBetween September 2008 and April 2012, APF excised from 282 patients who underwent RALP was sent for pathological analysis. This tissue was completely embedded and lymph nodes counted.ResultsIn total, 49/282 (17%) patients had lymph nodes in the APF, median lymph node yield in this tissue was 1 (range 1–5). In four patients, the lymph nodes contained metastatic deposits. These patients did not have positive nodes elsewhere in the extended lymph node dissection.ConclusionsAPF contains lymph nodes in 1 in 6 patients and infrequently these may be malignant. APF should always be removed at radical prostatectomy. APF should be routinely sent for pathological analysis.

scholarly journals Lymph node yield during surgery after neoadjuvant therapy compared to surgery without neoadjuvant therapy in patients with esophageal, gastric, pancreatic, or rectal carcinoma: systematic review and meta-analysis

2021 ◽  
Author(s):  
Ulrich Ronellenfitsch ◽  
Nika Maximov ◽  
Juliane Friedrichs ◽  
Jörg Kleeff
Keyword(s):  
Systematic Review ◽  
Lymph Node ◽  
Neoadjuvant Chemotherapy ◽  
Lymph Nodes ◽  
Neoadjuvant Therapy ◽  
Rectal Carcinoma ◽  
Meta Analysis ◽  
Lymph Node Yield ◽  
Gastrointestinal Carcinomas ◽  
Node Yield

Abstract Background: The lymph node yield is an important surrogate parameter for assessing the oncological radicality of the resection of gastrointestinal carcinomas and a prognostic factor in these diseases. It remains unclear if and to what extent neoadjuvant chemotherapy, radiotherapy or chemoradiotherapy, which have become established treatments for carcinoma of the esophagus, stomach, and rectum and are increasingly used in pancreatic carcinoma, affect the lymph node yield. This systematic review and meta-analysis intents to summarize the available evidence on the topic.Methods: Studies comparing oncological resection of esophageal, stomach, pancreatic and rectal carcinoma with and without prior neoadjuvant therapy are eligible for inclusion regardless of study design. Publications will be identified with a defined search strategy in the electronic databases PubMed and Cochrane Library. The primary endpoint of the analysis is the number of lymph nodes identified in the resected specimen. Secondary endpoints include number of harvested metastatic lymph nodes, operation time, postoperative complications, pTNM staging, and overall and recurrence-free survival time. Using suitable statistical methods, the endpoints between patients with and without neoadjuvant therapy as well as in defined subgroups (neoadjuvant chemotherapy, neoadjuvant radiotherapy, neoadjuvant chemoradiotherapy, and esophageal, gastric, pancreatic, and rectal cancer) will be compared Discussion: This systematic review with meta-analysis is conducted with the aim of summarizing the available evidence regarding the oncological surrogate marker lymph node yield in patients with gastrointestinal carcinomas undergoing surgery after neoadjuvant treatment compared to those operated without neoadjuvant therapy.Systematic review registration: This systematic review has been submitted for registration at PROSPERO, ID: 218459.

An Evaluation of Lymph Node Yield and Lymph Node Ratio in Well-Differentiated Thyroid Carcinoma

2010 ◽  
Vol 76 (1) ◽  
pp. 28-32 ◽  
Author(s):  
Shannon H. Beal ◽  
Steven L. Chen ◽  
Philip D. Schneider ◽  
Steve R. Martinez
Keyword(s):  
Lymph Node ◽  
Thyroid Carcinoma ◽  
Lymph Nodes ◽  
Lymph Node Ratio ◽  
Differentiated Thyroid Carcinoma ◽  
Lymph Node Yield ◽  
Node Negative ◽  
Node Ratio ◽  
Well Differentiated ◽  
Node Yield

It is unknown whether the number of lymph nodes harvested (lymph node yield, LNY) or the proportion of metastatic lymph nodes resected (metastatic lymph node ratio, MLNR) influence survival in well-differentiated thyroid carcinoma (WDTC). We hypothesized that overall survival in WDTC is influenced by the LNY and MLNR. We used the Surveillance, Epidemiology, and End Results database to identify all patients with primary, nonmetastatic WDTC who underwent thyroidectomy with at least one lymph node removed between 1988 and 2004. Kaplan-Meier survival curves for LNY and MLNR were compared using the log rank test. Multivariate Cox proportional hazards models included tumor and patient-specific factors. WDTC patients that met entry criteria totaled 9926. In the univariate model, LNY and MLNR had a significant impact on survival ( P < 0.001). In multivariate analysis, increasing LNY was associated with poorer survival in all patients ( P = 0.001) and node-negative patients ( P = 0.03), but not for node-positive patients ( P = 0.27). MLNR did not influence survival in node-positive patients ( P = 0.84). Among patients with WDTC treated with thyroidectomy and lymphadenectomy, increasing LNY and MLNR were associated with decreased survival. The decrease in survival associated with increasing LNY, even in node-negative patients, indicates that nodal understaging is inconsequential to WDTC survival.

Using the Fat-Clearing Technique to Improve Lymph Node Retrieval in Colorectal Cancer

2020 ◽  
pp. 106689692097550
Author(s):  
Chih-Ching Yeh ◽  
Chan-Feng Pan ◽  
Hung-Wei Liu ◽  
Jung-Chia Lin ◽  
Lu-Han Fang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Lymph Node ◽  
Lymph Nodes ◽  
Lymph Node Yield ◽  
Colorectal Cancer Resection ◽  
Lymph Node Retrieval ◽  
Clearing Technique ◽  
Lymph Node Harvesting ◽  
Node Yield ◽  
Gross Examination

College of American Pathologists recommended that at least 12 lymph nodes should be harvested for adequate staging of colorectal carcinoma. Lymph node harvesting is routinely performed by a manual technique of inspection and palpation, which is laborious and time-consuming. The study assessed the influence of the improved fat-clearing technique on the number of lymph nodes retrieved from colorectal cancer specimens and the clinical efficacy. Seventy colorectal cancer resection specimens were examined and assessed by 4 pathology residents. Thirty-five specimens were handled with the conventional manual technique by inspection and palpation, and the other 35 specimens with the improved fat-clearing technique to retrieve lymph nodes. As a result, compared with the conventional manual technique, the numbers of lymph nodes retrieved with the improved fat-clearing technique were significantly increased from 14.7 ± 6.2 lymph nodes to 20.8 ± 9.0 lymph nodes per specimen ( P < .05). Besides, the percentage of cases with at least 12 lymph nodes retrieved increased from 80% to 91%. The result of this study pointed out that using the improved fat-clearing technique to process colorectal specimens could increase the lymph node yield effectively, and was effective, practical, and suitable for routine gross examination.

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