Response to letter to the Editor re 'Outcomes of event-free survival in patients with Wilms tumor undergoing preoperative chemotherapy. Analysis of lymph-node yield in a single-center cohort'

2021 ◽  
Author(s):  
Paula Flores
Keyword(s):  
Lymph Node ◽  
Preoperative Chemotherapy ◽  
Wilms Tumor ◽  
Single Center ◽  
Event Free Survival ◽  
Lymph Node Yield ◽  
Free Survival ◽  
Letter To The Editor ◽  
Node Yield

The effect of preoperative chemotherapy on lymph node yield in gastric cancer.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 80-80
Author(s):  
J. L. Dikken ◽  
P. Krijnen ◽  
C. J. Van De Velde ◽  
M. Verheij ◽  
M. Gonen ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Lymph Node ◽  
Preoperative Chemotherapy ◽  
Distal Gastrectomy ◽  
High Volume ◽  
Curative Surgery ◽  
Lymph Node Yield ◽  
Younger Age ◽  
Node Yield ◽  
The U.S

80 Background: While a minimum of 15 lymphnodes (LNs) should be evaluated for accurate staging of gastric cancer, LN yield in western countries is generally low. With the increasing use of preoperative chemotherapy, it is unknown what the effect of this treatment is on lymph node yield. The aim of the study is therefore to determine whether preoperative chemotherapy influences the number of LNs that can be obtained from specimens of patients who underwent curative surgery for gastric adenocarcinoma. Methods: In1,205 patients from a high-volume U.S. center and 1,220 patients from the Netherlands Cancer Registry (NCR) who underwent a total or distal gastrectomy with curative intent for gastric adenocarcinoma, the LN yield was compared between patients who received preoperative chemotherapy and patients who received no neoadjuvant therapy. Multivariate Poisson regression was used to identify significant predictors of LN retrieval. Results: Of the 2,425 patients who underwent a gastrectomy, 340 patients (14%) received preoperative chemotherapy. Median LN yields were 23 in the U.S. institution and 10 in the NCR. Separate multivariate analyses of the U.S. institution data and the NCR population showed in both groups that preoperative chemotherapy was not associated with a significant difference in LN yield (Table). Factors that were associated with higher LN yield were the same in both groups: female sex, younger age (6% more nodes with every 10 years decrease in age), total gastrectomy (vs. distal gastrectomy) and increasing tumor (T) stage. Conclusions: In both a high-volume cancer center, and a population-based cancer registry, female sex, younger age, total gastrectomy and advanced tumor stage were associated with an increase in lymph node retrieval in surgical specimens. Preoperative chemotherapy did not influence lymph node yield after a resection for gastric cancer. The threshold for what should constitute an adequate assessment of regional lymph nodes after curative surgery for gastric cancer should not be changed after administration of preoperative chemotherapy. [Table: see text] No significant financial relationships to disclose.

scholarly journals How many lymph nodes are enough? Assessing the adequacy of lymph node yield for staging in favorable histology wilms tumor

2019 ◽  
Vol 54 (11) ◽  
pp. 2331-2335 ◽  
Author(s):  
Amanda F. Saltzman ◽  
Derek E. Smith ◽  
Dexiang Gao ◽  
Debashis Ghosh ◽  
Arya Amini ◽  
...  
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Wilms Tumor ◽  
Lymph Node Yield ◽  
Favorable Histology ◽  
Node Yield

Lymph node yield in treatment naïve cases of head and neck squamous cell carcinoma: en bloc lymphadenectomy versus level-by-level dissection

2021 ◽  
pp. 1-8
Author(s):  
K Devaraja ◽  
K Pujary ◽  
B Ramaswamy ◽  
D R Nayak ◽  
N Kumar ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Neck Dissection ◽  
Squamous Cell ◽  
Neck Squamous Cell Carcinoma ◽  
En Bloc ◽  
Lymph Node Yield ◽  
Node Yield

Abstract Background Lymph node yield is an important prognostic factor in head and neck squamous cell carcinoma. Variability in neck dissection sampling techniques has not been studied as a determinant of lymph node yield. Methods This retrospective study used lymph node yield and average nodes per level to compare level-by-level and en bloc neck dissection sampling methods, in primary head and neck squamous cell carcinoma cases operated between March 2017 and February 2020. Results From 123 patients, 182 neck dissections were analysed, of which 133 were selective and the rest were comprehensive: 55 had level-by-level sampling and 127 had undergone en bloc dissection. The level-by-level method yielded more nodes in all neck dissections combined (20 vs 17; p = 0.097), but the difference was significant only for the subcohort of selective neck dissection (18.5 vs 15; p = 0.011). However, the gain in average nodes per level achieved by level-by-level sampling was significant in both groups (4.2 vs 3.33 and 4.4 vs 3, respectively; both p < 0.001). Conclusion Sampling of cervical lymph nodes level-by-level yields more nodes than the en bloc technique. Further studies could verify whether neck dissection sampling technique has any impact on survival rates.

Accuracy of the Lymph Node Yield in Surgery for Papillary Thyroid Cancer in Children

2021 ◽  
Author(s):  
Ava Yap ◽  
Amy Shui ◽  
Jessica Gosnell ◽  
Chiung-Yu Huang ◽  
Julie Ann Sosa ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Lymph Node ◽  
Papillary Thyroid Cancer ◽  
Papillary Thyroid ◽  
Lymph Node Yield ◽  
Cancer In Children ◽  
Node Yield
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