scholarly journals Coronary endothelial dysfunction prevented by small-conductance calcium-activated potassium channel activator in mice and patients with diabetes

2020 ◽  
Vol 160 (6) ◽  
pp. e263-e280
Author(s):  
Zhiqi Zhang ◽  
Guangbin Shi ◽  
Yuhong Liu ◽  
Hang Xing ◽  
Anatoli Y. Kabakov ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Potassium Channel ◽  
Potassium Channel Activator ◽  
Patients With Diabetes ◽  
Calcium Activated Potassium Channel ◽  
Coronary Endothelial Dysfunction ◽  
Small Conductance ◽  
Channel Activator

scholarly journals Nicorandil-Induced Hyperkalemia in a Uremic Patient

2012 ◽  
Vol 2012 ◽  
pp. 1-4 ◽  
Author(s):  
Hung-Hao Lee ◽  
Po-Chao Hsu ◽  
Tsung-Hsien Lin ◽  
Wen-Ter Lai ◽  
Sheng-Hsiung Sheu
Keyword(s):  
Potassium Channel ◽  
Potassium Ions ◽  
Uremic Patient ◽  
Membrane Hyperpolarization ◽  
Voltage Gated ◽  
Antianginal Agent ◽  
Voltage Gated Calcium Channels ◽  
Detailed Evaluation ◽  
Potassium Channel Activator ◽  
Channel Activator

Nicorandil is an antianginal agent with nitrate-like and ATP-sensitive potassium channel activator properties. After activation of potassium channels, potassium ions are expelled out of the cells, which lead to membrane hyperpolarization, closure of voltage-gated calcium channels, and finally vasodilation. We present a uremic case suffering from repeated junctional bradycardia, especially before hemodialysis. After detailed evaluation, nicorandil was suspected to be the cause of hyperkalemia which induced bradycardia. This case reminds us that physicians should be aware of this potential complication in patients receiving ATP-sensitive potassium channel activator.

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