scholarly journals Afatinib-Induced Severe Interstitial Lung Disease Successfully Treated with High-Dose Corticosteroid Therapy: A Case Report

2017 ◽  
Vol 12 (2) ◽  
pp. e11-e13 ◽  
Author(s):  
Kazutaka Fujita ◽  
Yuko Morishima ◽  
Yuka Aida ◽  
Yoshiya Tsunoda ◽  
Norihito Hida ◽  
...  
Keyword(s):  
Case Report ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Corticosteroid Therapy ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

scholarly journals Aspergillosis Superinfection as a Cause of Death of Crizotinib-Induced Interstitial Lung Disease Successfully Treated with High-Dose Corticosteroid Therapy

2015 ◽  
Vol 8 (1) ◽  
pp. 169-173 ◽  
Author(s):  
Laura Deiana ◽  
Salvatore Grisanti ◽  
Vittorio Ferrari ◽  
Andrea Tironi ◽  
Giulia Brugnoli ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Corticosteroid Therapy ◽  
High Dose ◽  
Small Cell Lung ◽  
Serious Adverse Event ◽  
High Dose Corticosteroid ◽  
Alk Positive ◽  
Dose Corticosteroid

Crizotinib is an efficacious and well-tolerated drug in the management of ALK-positive lung cancer. Crizotinib treatment, however, is rarely complicated by the occurrence of acute interstitial lung disease (ILD) that is often fatal. There is no treatment for this serious adverse event. We report a female non-small cell lung cancer patient who developed ILD after a few days of crizotinib therapy. She showed a significant improvement after a high dose of pulse corticosteroid therapy, both radiologically and clinically. Unfortunately, the patient subsequently developed an aspergillosis superinfection leading to death. Our experience suggests that high-dose steroid therapy may be efficacious in the management of a severe complication of crizotinib therapy. However, potent antifungal therapy should be considered to prevent the risk of severe aspergillosis.

Indications for Tonsillectomy in Infectious Mononucleosis

PEDIATRICS ◽  
1971 ◽  
Vol 48 (2) ◽  
pp. 338-339
Author(s):  
Edward J. Feroli ◽  
Gordon W. Mella ◽  
Frank A. Pedreira ◽  
Regis T. Storch ◽  
Howard P. Gutgesell
Keyword(s):  
Case Report ◽  
Infectious Mononucleosis ◽  
Community Hospital ◽  
Nasotracheal Intubation ◽  
Benign Disease ◽  
Therapeutic Modality ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Acute Airway Obstruction ◽  
Dose Corticosteroid

We read with interest the recent report, "Acute Airway Obstruction in Infectious Mononucleosis."1 Dr. Gutgesell appropriately has called attention to a serious complication of a usually benign disease. He mentions brief, high-dose corticosteroid therapy, tracheotomy, nasotracheal intubation, and IPPB as potential modes of therapy. The following case report suggests an additional therapeutic modality in the management of these patients. A 4-year-old girl was admitted to a community hospital in acute respiratory distress associated with suspected infectious mononucleosis.

Sustained hemostatic abnormality in patients with steroid-induced osteonecrosis in the early period after high-dose corticosteroid therapy

2000 ◽  
Vol 5 (4) ◽  
pp. 374-379 ◽  
Author(s):  
Kazuhiro Oinuma ◽  
Yoshitada Harada ◽  
Yasushi Nawata ◽  
Katsuhiko Takabayashi ◽  
Isao Abe ◽  
...  
Keyword(s):  
Corticosteroid Therapy ◽  
Early Period ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid

Ethosuximide-induced Stevens-Johnson syndrome: Beneficial effect of early intervention with high-dose corticosteroid therapy

2018 ◽  
Vol 45 (5) ◽  
pp. 592-595 ◽  
Author(s):  
Kota Tachibana ◽  
Toshihisa Hamada ◽  
Hiroki Tsuchiya ◽  
Takashi Shibata ◽  
Kazuyasu Fujii ◽  
...  
Keyword(s):  
Early Intervention ◽  
Beneficial Effect ◽  
Corticosteroid Therapy ◽  
Stevens Johnson Syndrome ◽  
High Dose ◽  
High Dose Corticosteroid ◽  
Johnson Syndrome ◽  
Dose Corticosteroid

Bone Complications of Corticosteroids

1996 ◽  
Vol 1 (1) ◽  
pp. 50-57 ◽  
Author(s):  
Robert S. Lester
Keyword(s):  
Corticosteroid Therapy ◽  
Low Dose ◽  
Treatment Options ◽  
Osteoporotic Fractures ◽  
High Dose ◽  
Systemic Complications ◽  
High Dose Corticosteroid ◽  
Systemic Corticosteroids ◽  
Dose Corticosteroid ◽  
Bone Complications

Background: Systemic corticosteroids, a mainstay of treatment for severe dermatosis, are associated with systemic complications. Adverse effects of corticosteroids to bone represent a significant adverse effect that, is poorly understood and poorly managed. Objectives: The purpose of this article is to educate dermatologists to the current understanding of the pathogenesis, diagnosis, and treatment options available for bone complications of corticosteroids. Results: Virtually all patients chronically exposed to high-dose corticosteroid therapy lose bone mass and are at risk for osteoporotic fractures. In addition, osteonecrosis is an unpredictable complication of corticosteroid therapy that may occur with even low-dose corticosteroids. Conclusion: Optimal risk management of corticosteroid therapy includes understanding the risk factors associated with bone complications and improving communication with patients.

Myelofibrosis and Systemic Lupus erythematosus: Reversal of Fibrosis with High-Dose Corticosteroid Therapy

1992 ◽  
Vol 88 (1) ◽  
pp. 32-36 ◽  
Author(s):  
Yasushi Inoue ◽  
Atsushi Matsubara ◽  
Shigeru Okuya ◽  
Koichiro Okafuji ◽  
Kohei Kaku ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Corticosteroid Therapy ◽  
Lupus Erythematosus ◽  
High Dose ◽  
Systemic Lupus ◽  
High Dose Corticosteroid ◽  
Dose Corticosteroid
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