2138 IMPROVING VAGINAL SMOOTH MUSCLE ELASTIN DEPOSITION IN A GENETIC MODEL OF PELVIC ORGAN PROLAPSE: POTENTIAL PATHOPHYSIOLOGY-BASED THERAPY

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Lavanya Venkataraman ◽  
Andrew T. Lenis ◽  
Bruna M. Couri ◽  
Anand Ramamurthi ◽  
Margot S. Damaser
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Genetic Model ◽  
Pelvic Organ ◽  
Vaginal Smooth Muscle ◽  
Elastin Deposition

Vaginal smooth muscle cell apoptosis is increased in women with pelvic organ prolapse

2008 ◽  
Vol 19 (11) ◽  
pp. 1559-1564 ◽  
Author(s):  
Peter Takacs ◽  
Marc Gualtieri ◽  
Mehdi Nassiri ◽  
Keith Candiotti ◽  
Carlos. A. Medina
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Smooth Muscle Cell ◽  
Muscle Cell ◽  
Cell Apoptosis ◽  
Pelvic Organ ◽  
Muscle Cell Apoptosis ◽  
Vaginal Smooth Muscle

scholarly journals Changes in muscularis propria of anterior vaginal wall in women with pelvic organ prolapse

2016 ◽  
Vol 60 (1) ◽  
Author(s):  
A. Vetuschi ◽  
A. D'Alfonso ◽  
R. Sferra ◽  
D. Zanelli ◽  
S. Pompili ◽  
...  
Keyword(s):  
Risk Factors ◽  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Smooth Muscle Cells ◽  
Muscularis Propria ◽  
Muscle Cells ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall ◽  
Collagen Iii

<p>The objective<strong> </strong>of this study was to evaluate the morphological and immunohistochemical alterations of tissue removed from the upper third of anterior vaginal wall in a sample group of the female population presenting homogenous risk factors associated with Pelvic Organ Prolapse (POP). The case study consisted of 14 patients with POP and there were 10 patients in the control group. Patient selection was carried on the basis of specific criteria and all of the patients involved in the study presented one or more of the recognized POP risk factors. Samples were taken from POP patients during vaginal plastic surgery following  colpohysterectomy, and from control patients during closure of the posterior fornix following hysterectomy. Samples were processed for histological and  immunohistochemical analyses for Collagen I and Collagen III, α-Smooth Muscle Actin (α-SMA), Platelet-Derived-Growth-Factor (PDGF), matrix metalloproteinase 3 (MMP3), Caspase3. Immunofluorescence analyses for Collagen I and III and PDGF were also carried out. In prolapsed specimens our results show a disorganization of smooth muscle cells that appeared to have been displaced by an increased collagen III deposition resulting in rearrangement of the muscularis propria architecture. These findings suggest that the increase in the expression of collagen fibers in muscularis could probably due to a phenotypic switch resulting in the dedifferentiation of smooth muscle cells into myofibroblasts. These alterations could be responsible for the compromising of the dynamic functionality of the pelvic floor.</p><p><strong> </strong></p>

Morphometric analysis of smooth muscle in the anterior vaginal wall of women with pelvic organ prolapse

2002 ◽  
Vol 187 (1) ◽  
pp. 56-63 ◽  
Author(s):  
Muriel K. Boreham ◽  
Clifford Y. Wai ◽  
Rodney T. Miller ◽  
Joseph I. Schaffer ◽  
R.Ann Word
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Morphometric Analysis ◽  
Pelvic Organ ◽  
Vaginal Wall ◽  
Anterior Vaginal Wall

The Role of Smooth Muscle Cells in the Pathophysiology of Pelvic Organ Prolapse

2013 ◽  
Vol 19 (5) ◽  
pp. 254-259 ◽  
Author(s):  
Shanshan Mei ◽  
Ming Ye ◽  
Laura Gil ◽  
Jianping Zhang ◽  
Yanping Zhang ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Smooth Muscle Cells ◽  
Muscle Cells ◽  
Pelvic Organ

Smooth muscle fraction of the round ligament in women with pelvic organ prolapse: a computer-based morphometric analysis

2004 ◽  
Vol 16 (1) ◽  
pp. 39-43 ◽  
Author(s):  
Ozlem Ozdegirmenci ◽  
Yildirim Karslioglu ◽  
Suat Dede ◽  
Sinan Karadeniz ◽  
Ali Haberal ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Morphometric Analysis ◽  
Pelvic Organ ◽  
Round Ligament ◽  
Computer Based

Expression of genes encoding smooth muscle contractile proteins in vaginal tissue of women with and without pelvic organ prolapse

2011 ◽  
Vol 31 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Maria A.T. Bortolini ◽  
Oksana Shynlova ◽  
Harold P. Drutz ◽  
Rodrigo A. Castro ◽  
Manoel J.B.C. Girão ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Pelvic Organ Prolapse ◽  
Pelvic Organ ◽  
Contractile Proteins ◽  
Vaginal Tissue ◽  
Expression Of Genes ◽  
Genes Encoding ◽  
Muscle Contractile
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