754 EXPEDIENCY OF EARLY ORCHIOPEXY FOR SPERMATOGONIAL STEM CELL ACTIVITY AND APOPTOSIS IN CRYPTORCHID TESTES

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Hideyuki Kamisawa ◽  
Kentaro Mizuno ◽  
Makoto Imura ◽  
Yoshinobu Moritoki ◽  
Hidenori Nishio ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells

Cell Reports ◽  
2016 ◽  
Vol 17 (10) ◽  
pp. 2789-2804 ◽  
Author(s):  
Yukiko Ishikura ◽  
Yukihiro Yabuta ◽  
Hiroshi Ohta ◽  
Katsuhiko Hayashi ◽  
Tomonori Nakamura ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Pluripotent Stem Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals A transit-amplifying population underpins the efficient regenerative capacity of the testis

2017 ◽  
Vol 214 (6) ◽  
pp. 1631-1641 ◽  
Author(s):  
Claudia Carrieri ◽  
Stefano Comazzetto ◽  
Amit Grover ◽  
Marcos Morgan ◽  
Andreas Buness ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tissue Repair ◽  
Cell Activity ◽  
Adult Life ◽  
Spermatogonial Stem Cell ◽  
Mouse Testis ◽  
Regenerative Capacity ◽  
Cell Pool ◽  
Stem Cell Activity ◽  
Stem Cell Pool

The spermatogonial stem cell (SSC) that supports spermatogenesis throughout adult life resides within the GFRα1-expressing A type undifferentiated spermatogonia. The decision to commit to spermatogenic differentiation coincides with the loss of GFRα1 and reciprocal gain of Ngn3 (Neurog3) expression. Through the analysis of the piRNA factor Miwi2 (Piwil4), we identify a novel population of Ngn3-expressing spermatogonia that are essential for efficient testicular regeneration after injury. Depletion of Miwi2-expressing cells results in a transient impact on testicular homeostasis, with this population behaving strictly as transit amplifying cells under homeostatic conditions. However, upon injury, Miwi2-expressing cells are essential for the efficient regenerative capacity of the testis, and also display facultative stem activity in transplantation assays. In summary, the mouse testis has adopted a regenerative strategy to expand stem cell activity by incorporating a transit-amplifying population to the effective stem cell pool, thus ensuring rapid and efficient tissue repair.

Attenuation of Spermatogonial Stem Cell Activity in Cryptorchid Testes

2012 ◽  
Vol 187 (3) ◽  
pp. 1047-1052 ◽  
Author(s):  
Hideyuki Kamisawa ◽  
Yoshiyuki Kojima ◽  
Kentaro Mizuno ◽  
Makoto Imura ◽  
Yutaro Hayashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals Sustained CTNNB1 Signaling in Sertoli Cells Downregulates Spermatogonial Stem Cell Activity via WNT4.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 545-545
Author(s):  
Alexandre Boyer ◽  
Jonathan R. Yeh ◽  
Xiangfan Zhang ◽  
Makoto C. Nagano ◽  
Derek Boerboom
Keyword(s):  
Stem Cell ◽  
Sertoli Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals CTNNB1 Signaling in Sertoli Cells Downregulates Spermatogonial Stem Cell Activity via WNT4

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29764 ◽  
Author(s):  
Alexandre Boyer ◽  
Jonathan R. Yeh ◽  
Xiangfan Zhang ◽  
Marilène Paquet ◽  
Aurore Gaudin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sertoli Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

216 SPERMATOGONIAL STEM CELL ACTIVITY IN CRYPTORCHID TESTES

2012 ◽  
Vol 187 (4S) ◽  
Author(s):  
Hideyuki Kamisawa ◽  
Kentaro Mizuno ◽  
Yoshiyuki Kojima ◽  
Satoshi Kurokawa ◽  
Yoshinobu Moritoki ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity
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