scholarly journals A transit-amplifying population underpins the efficient regenerative capacity of the testis

2017 ◽  
Vol 214 (6) ◽  
pp. 1631-1641 ◽  
Author(s):  
Claudia Carrieri ◽  
Stefano Comazzetto ◽  
Amit Grover ◽  
Marcos Morgan ◽  
Andreas Buness ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tissue Repair ◽  
Cell Activity ◽  
Adult Life ◽  
Spermatogonial Stem Cell ◽  
Mouse Testis ◽  
Regenerative Capacity ◽  
Cell Pool ◽  
Stem Cell Activity ◽  
Stem Cell Pool

The spermatogonial stem cell (SSC) that supports spermatogenesis throughout adult life resides within the GFRα1-expressing A type undifferentiated spermatogonia. The decision to commit to spermatogenic differentiation coincides with the loss of GFRα1 and reciprocal gain of Ngn3 (Neurog3) expression. Through the analysis of the piRNA factor Miwi2 (Piwil4), we identify a novel population of Ngn3-expressing spermatogonia that are essential for efficient testicular regeneration after injury. Depletion of Miwi2-expressing cells results in a transient impact on testicular homeostasis, with this population behaving strictly as transit amplifying cells under homeostatic conditions. However, upon injury, Miwi2-expressing cells are essential for the efficient regenerative capacity of the testis, and also display facultative stem activity in transplantation assays. In summary, the mouse testis has adopted a regenerative strategy to expand stem cell activity by incorporating a transit-amplifying population to the effective stem cell pool, thus ensuring rapid and efficient tissue repair.

754 EXPEDIENCY OF EARLY ORCHIOPEXY FOR SPERMATOGONIAL STEM CELL ACTIVITY AND APOPTOSIS IN CRYPTORCHID TESTES

2013 ◽  
Vol 189 (4S) ◽  
Author(s):  
Hideyuki Kamisawa ◽  
Kentaro Mizuno ◽  
Makoto Imura ◽  
Yoshinobu Moritoki ◽  
Hidenori Nishio ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals In Vitro Derivation and Propagation of Spermatogonial Stem Cell Activity from Mouse Pluripotent Stem Cells

Cell Reports ◽  
2016 ◽  
Vol 17 (10) ◽  
pp. 2789-2804 ◽  
Author(s):  
Yukiko Ishikura ◽  
Yukihiro Yabuta ◽  
Hiroshi Ohta ◽  
Katsuhiko Hayashi ◽  
Tomonori Nakamura ◽  
...  
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Pluripotent Stem Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals The mTORC1 component RPTOR is required for maintenance of the foundational spermatogonial stem cell pool in mice†

2018 ◽  
Vol 100 (2) ◽  
pp. 429-439 ◽  
Author(s):  
Nicholas Serra ◽  
Ellen K Velte ◽  
Bryan A Niedenberger ◽  
Oleksander Kirsanov ◽  
Christopher B Geyer
Keyword(s):  
Stem Cell ◽  
Spermatogonial Stem Cell ◽  
Cell Pool ◽  
Stem Cell Pool

Attenuation of Spermatogonial Stem Cell Activity in Cryptorchid Testes

2012 ◽  
Vol 187 (3) ◽  
pp. 1047-1052 ◽  
Author(s):  
Hideyuki Kamisawa ◽  
Yoshiyuki Kojima ◽  
Kentaro Mizuno ◽  
Makoto Imura ◽  
Yutaro Hayashi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals Gilgamesh (Gish)/CK1γ regulates tissue homeostasis and aging in adult Drosophila midgut

2020 ◽  
Vol 219 (4) ◽  
Author(s):  
Shuangxi Li ◽  
Aiguo Tian ◽  
Shuang Li ◽  
Yuhong Han ◽  
Bing Wang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Activity ◽  
Adult Life ◽  
Small Gtpase ◽  
Tissue Homeostasis ◽  
Jnk Pathway ◽  
Pathway Activation ◽  
Stem Cell Activity ◽  
Resident Stem Cells ◽  
Jnk Activation

Adult tissues and organs rely on resident stem cells to generate new cells that replenish damaged cells. To maintain homeostasis, stem cell activity needs to be tightly controlled throughout the adult life. Here, we show that the membrane-associated kinase Gilgamesh (Gish)/CK1γ maintains Drosophila adult midgut homeostasis by restricting JNK pathway activity and that Gish is essential for intestinal stem cell (ISC) maintenance under stress conditions. Inactivation of Gish resulted in aberrant JNK pathway activation and excessive production of multiple cytokines and growth factors that drive ISC overproliferation. Mechanistically, Gish restricts JNK activation by phosphorylating and destabilizing a small GTPase, Rho1. Interestingly, we find that Gish expression is down-regulated in aging guts and that increasing Gish activity in aging guts can restore tissue homeostasis. Hence, our study identifies Gish/CK1γ as a novel regulator of Rho1 and gatekeeper of tissue homeostasis whose activity is compromised in aging guts.

scholarly journals Three-dimensional niche stiffness synergizes with Wnt7a to modulate the extent of satellite cell symmetric self-renewal divisions

2020 ◽  
Vol 31 (16) ◽  
pp. 1703-1713
Author(s):  
Louise A. Moyle ◽  
Richard Y. Cheng ◽  
Haijiao Liu ◽  
Sadegh Davoudi ◽  
Silvia A. Ferreira ◽  
...  
Keyword(s):  
Stem Cell ◽  
Tissue Repair ◽  
Stem Cell Niche ◽  
Three Dimensional ◽  
Repair Process ◽  
Self Renewal ◽  
Muscle Stem Cell ◽  
Cell Pool ◽  
Cell Niche ◽  
Stem Cell Pool

The skeletal muscle stem cell niche transiently stiffens during the tissue repair process, which serves to increase planar-oriented divisions and, when combined with WNT7a, induces symmetric cell division to expand the stem cell pool.

scholarly journals Sustained CTNNB1 Signaling in Sertoli Cells Downregulates Spermatogonial Stem Cell Activity via WNT4.

2011 ◽  
Vol 85 (Suppl_1) ◽  
pp. 545-545
Author(s):  
Alexandre Boyer ◽  
Jonathan R. Yeh ◽  
Xiangfan Zhang ◽  
Makoto C. Nagano ◽  
Derek Boerboom
Keyword(s):  
Stem Cell ◽  
Sertoli Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity

scholarly journals CTNNB1 Signaling in Sertoli Cells Downregulates Spermatogonial Stem Cell Activity via WNT4

PLoS ONE ◽  
2012 ◽  
Vol 7 (1) ◽  
pp. e29764 ◽  
Author(s):  
Alexandre Boyer ◽  
Jonathan R. Yeh ◽  
Xiangfan Zhang ◽  
Marilène Paquet ◽  
Aurore Gaudin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Sertoli Cells ◽  
Cell Activity ◽  
Spermatogonial Stem Cell ◽  
Stem Cell Activity
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