Diagnosing Laryngopharyngeal Reflux: A Comparison between 24-hour pH-Impedance Testing and Pharyngeal Probe (Restech) Testing, with Introduction of the Sataloff Score

Background and Aims: Pepsin in the gastric refluxate is a marker for a prior reflux event and rapid detection might be achieved using the Peptest™, an in vitro diagnostic medical device. The aim of this study was to validate the use of Peptest™ to reliably diagnose reflux in patients with gastro-esophageal reflux disease (GERD) and laryngopharyngeal reflux (LPR) disease diagnosed with multichannel intraluminal impedance/ pHmetry (MII-pH). Methods: 20 reflux patients were recruited of whom 10 had classical GERD and 10 had LPR. All patients underwent MII-pH and provided expectorated saliva samples when a MII-pH reflux event was observed, or reflux symptoms were experienced, and all were tested for the presence of pepsin using the Peptest™. Results: Pepsin was detected in 31 out of 45 samples (68.9%). At least 1 positive pepsin result was seen in 16 patients (80%) and this was the same, irrespective of the GERD or LPR diagnosis. Peptest™ had a positive predictive value of 69% to detect MII-pH reflux events. Conclusions: Peptest™ is a good first-line diagnostic procedure to use in reflux sufferers to confirm the presence of reflux.

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Dual pH with Multichannel Intraluminal Impedance Testing in the Evaluation of Subjective Laryngopharyngeal Reflux Symptoms

Otolaryngology ◽

10.1177/0194599816665819 ◽

2016 ◽

Vol 155 (6) ◽

pp. 1014-1020 ◽

Cited By ~ 21

Author(s):

Evan C. Cumpston ◽

Joel H. Blumin ◽

Jonathan M. Bock

Keyword(s):

Laryngopharyngeal Reflux ◽

Multichannel Intraluminal Impedance ◽

Reflux Symptoms ◽

Intraluminal Impedance ◽

Impedance Testing

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Su1071 - Symptoms Classically Attributed to Laryngopharyngeal Reflux (LPR) Correlate Poorly with Pharyngeal Events on Impedance Testing

Gastroenterology ◽

10.1016/s0016-5085(18)31827-4 ◽

2018 ◽

Vol 154 (6) ◽

pp. S-476

Author(s):

Sanjay Salgado ◽

Lawrence F. Borges ◽

Wai-Kit Lo ◽

Thomas L. Carroll ◽

Walter W. Chan

Keyword(s):

Laryngopharyngeal Reflux ◽

Impedance Testing

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Nissen Fundoplication for Laryngopharyngeal Reflux After Patient Selection Using Dual pH, Full Column Impedance Testing

Annals of Otology Rhinology & Laryngology ◽

10.1177/0003489416649974 ◽

2016 ◽

Vol 125 (9) ◽

pp. 722-728 ◽

Cited By ~ 10

Author(s):

Thomas L. Carroll ◽

Kael Nahikian ◽

Ammar Asban ◽

Daniel Wiener

Keyword(s):

Patient Selection ◽

Nissen Fundoplication ◽

Laryngopharyngeal Reflux ◽

Impedance Testing

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The Laryngeal Epithelium in Reflux

Perspectives on Voice and Voice Disorders ◽

10.1044/vvd21.3.112 ◽

2011 ◽

Vol 21 (3) ◽

pp. 112-117 ◽

Cited By ~ 2

Author(s):

Elizabeth Erickson-Levendoski ◽

Mahalakshmi Sivasankar

Keyword(s):

Laryngopharyngeal Reflux ◽

Critical Role ◽

Structure And Function ◽

Laryngeal Disease ◽

Health And Disease ◽

And Function ◽

The Impact

The epithelium plays a critical role in the maintenance of laryngeal health. This is evident in that laryngeal disease may result when the integrity of the epithelium is compromised by insults such as laryngopharyngeal reflux. In this article, we will review the structure and function of the laryngeal epithelium and summarize the impact of laryngopharyngeal reflux on the epithelium. Research investigating the ramifications of reflux on the epithelium has improved our understanding of laryngeal disease associated with laryngopharyngeal reflux. It further highlights the need for continued research on the laryngeal epithelium in health and disease.

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