Evaluation of Functional Capacity and Muscle Metabolism in Individuals with Peripheral Arterial Disease with and without Diabetes

2021 ◽  
Author(s):  
Patrícia Paulino Geisel ◽  
Débora Pantuso Monteiro ◽  
Isabella de Oliveira Nascimento ◽  
Danielle Aparecida Gomes Pereira
Keyword(s):  
Peripheral Arterial Disease ◽  
Functional Capacity ◽  
Muscle Metabolism ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals 1042 Multi-modality magnetic resonance demonstrates factors critical to functional capacity in peripheral arterial disease

2008 ◽  
Vol 10 (S1) ◽  
Author(s):  
Justin D Anderson ◽  
Frederick H Epstein ◽  
Craig H Meyer ◽  
Klaus D Hagspiel ◽  
Stuart S Berr ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Peripheral Arterial Disease ◽  
Functional Capacity ◽  
Arterial Disease ◽  
Peripheral Arterial

Skeletal Muscle Metabolism as a Target for Drug Therapy in Peripheral Arterial Disease

1996 ◽  
Vol 1 (1) ◽  
pp. 55-59 ◽  
Author(s):  
Eric P Brass
Keyword(s):  
Skeletal Muscle ◽  
Peripheral Arterial Disease ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Muscle Metabolism ◽  
Arterial Disease ◽  
Metabolic Dysfunction ◽  
Skeletal Muscle Metabolism ◽  
Peripheral Arterial ◽  
Novel Therapeutic Strategies

Peripheral arterial disease (PAD) is an atherosclerotic disease which modifies lower extremity hemodynamics. There is considerable evidence that skeletal muscle metabolism is altered in PAD. Several studies have demonstrated altered mitochondrial enzyme content in PAD muscle as compared with controls, and enzyme activity may not increase normally in PAD with exercise training. A variety of metabolic intermediates, including acylcarnitines, accumulate in muscle of PAD patients, suggesting incomplete oxidative metabolism. Studies employing 31P-NMR (nuclear magnetic resonance) also suggest a metabolic myopathy in PAD. Strikingly, while hemodynamics do not predict claudication-limited performance, metabolic injury as evidenced by acylcarnitine accumulation is strongly correlated with patients' functional status in PAD. Further, exercise rehabilitation improves claudication-limited performance without modifying large vessel hemodynamics. The stress placed on skeletal muscle during exercise in PAD and the observed evidence of metabolic dysfunction is similar to ischemia/reperfusion injury in cardiac muscle. Recognition of the role of cellular metabolic injury and function in PAD has formed the basis for novel therapeutic strategies in this disease.

scholarly journals Determinants of Functional Capacity in Peripheral Arterial Disease

2010 ◽  
Vol 55 (6) ◽  
pp. 609-610 ◽  
Author(s):  
Pierre Abraham ◽  
Guillaume Mahé ◽  
Antoine Bruneau ◽  
Georges Leftheriotis
Keyword(s):  
Peripheral Arterial Disease ◽  
Functional Capacity ◽  
Arterial Disease ◽  
Peripheral Arterial

scholarly journals Effects of modified aerobic training on muscle metabolism in individuals with peripheral arterial disease: a randomized clinical trial

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Débora Pantuso Monteiro ◽  
Giane Amorim Ribeiro-Samora ◽  
Raquel Rodrigues Britto ◽  
Danielle Aparecida Gomes Pereira
Keyword(s):  
Clinical Trial ◽  
Peripheral Arterial Disease ◽  
Randomized Clinical Trial ◽  
Near Infrared ◽  
Aerobic Training ◽  
Muscle Metabolism ◽  
Arterial Disease ◽  
Primary Objective ◽  
Lower Limbs ◽  
Peripheral Arterial

Abstract The primary objective of this study was to compare the effects on muscle metabolism of two types of aerobic training, with and without a load on the lower limbs, in adults with peripheral arterial disease (PAD). A simple blind randomized clinical trial was conducted using two groups: conventional aerobic (CG) and modified aerobic with a load on the lower limbs (MG). Both groups underwent training by walking three times a week over a 12-week period. The ratings of muscle metabolism were determined after a treadmill test with constant velocity and inclination concomitant with the use of near infrared spectroscopy (NIRS). Altogether 40 individuals with PAD (CG = 65.45 ± 10.60 and MG = 63.10 ± 10.54) were included in the study. After the intervention, in both groups, there was a reduction in the relative time to recovery (p = 0.002), an improvement in the re-oxygenation rate (p = 0.017), an increased time of resistance after reaching the lowest muscle oxygen saturation (StO2) (p < 0.001), an increase in the distance walked (p < 0.001), and an improvement of the walking economy relative to StO2 (p < 0.001). After 12 weeks of training, an improvement in the deoxygenation rate was observed in both groups (p = 0.002), but with a greater magnitude in the CG (p = 0.017). Only the CG presented an increase in time to reach the lowest StO2 on the treadmill after the intervention (p = 0.010). The traditional aerobic training was superior to the modified training in relation to the improvement of muscle metabolism in patients with PAD.

scholarly journals Effect of Creatine Supplementation on Functional Capacity and Muscle Oxygen Saturation in Patients with Symptomatic Peripheral Arterial Disease: A Pilot Study of a Randomized, Double-Blind Placebo-Controlled Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (1) ◽  
pp. 149
Author(s):  
Wagner Jorge Ribeiro Domingues ◽  
Raphael Mendes Ritti-Dias ◽  
Gabriel Grizzo Cucato ◽  
Nelson Wolosker ◽  
Antônio Eduardo Zerati ◽  
...  
Keyword(s):  
Peripheral Arterial Disease ◽  
Oxygen Saturation ◽  
Functional Capacity ◽  
Maintenance Phase ◽  
Arterial Disease ◽  
Calf Muscle ◽  
Walking Distance ◽  
Double Blind ◽  
Muscle Oxygen ◽  
Peripheral Arterial

The aim of the study was to verify the effects of creatine (Cr) supplementation on functional capacity (walking capacity; primary outcome) and calf muscle oxygen saturation (StO2) (secondary outcome) in symptomatic peripheral arterial disease (PAD) patients. Twenty-nine patients, of both sexes, were randomized (1:1) in a double-blind manner for administration of placebo (PLA, n = 15) or creatine monohydrate (Cr, n = 14). The supplementation protocol consisted of 20 g/day for 1 week divided into four equal doses (loading phase), followed by single daily doses of 5 g in the subsequent 7 weeks (maintenance phase). Functional capacity (total walking distance) was assessed by the 6 min walk test, and calf muscle StO2 was assessed through near infrared spectroscopy. The measurements were collected before and after loading and after the maintenance phase. The level of significance was p < 0.05. No significant differences were found for function capacity (total walking distance (PLA: pre 389 ± 123 m vs. post loading 413 ± 131 m vs. post maintenance 382 ± 99 m; Cr: pre 373 ± 149 m vs. post loading 390 ± 115 m vs. post maintenance 369 ± 115 m, p = 0.170) and the calf muscle StO2 parameters (p > 0.05). Short- and long-term Cr supplementation does not influence functional capacity and calf muscle StO2 parameters in patients with symptomatic PAD.

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