A multicenter blinded preclinical randomized controlled trial on Jak1/2 inhibition in MRL/MpJ-Fas mice with proliferative lupus nephritis predicts low effect size

2021 ◽  
Author(s):  
Yutian Lei ◽  
Bettina Sehnert ◽  
Reinhard E. Voll ◽  
Conxita Jacobs-Cachá ◽  
Maria Jose Soler ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lupus Nephritis ◽  
Effect Size ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Proliferative Lupus Nephritis

Randomized controlled trial of pulse/synchronization cyclophosphamide/apheresis for proliferative lupus nephritis

1998 ◽  
Vol 13 (4) ◽  
pp. 163-166 ◽  
Author(s):  
Daniel J. Wallace ◽  
Dennis Goldfinger ◽  
Samuel H. Pepkowitz ◽  
Marshal Fichman ◽  
Allan L. Metzger ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lupus Nephritis ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Proliferative Lupus Nephritis ◽  
Pulse Synchronization

scholarly journals Azathioprine/methylprednisolone versus cyclophosphamide in proliferative lupus nephritis. A randomized controlled trial

2006 ◽  
Vol 70 (4) ◽  
pp. 732-742 ◽  
Author(s):  
C. Grootscholten ◽  
◽  
G. Ligtenberg ◽  
E.C. Hagen ◽  
A.W.L. van den Wall Bake ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lupus Nephritis ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Proliferative Lupus Nephritis

scholarly journals Comparison of two steroid regimens in induction therapy of proliferative lupus nephritis: A randomized controlled trial

2019 ◽  
Vol 29 (5) ◽  
pp. 373
Author(s):  
KrishanLal Gupta ◽  
Joyita Bharati ◽  
Manish Rathi ◽  
Raja Ramachandran ◽  
Aman Sharma ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lupus Nephritis ◽  
Induction Therapy ◽  
Controlled Trial ◽  
Randomized Controlled ◽  
Proliferative Lupus Nephritis

scholarly journals Adherence to a Lifestyle Exercise and Nutrition Intervention in University Employees during the COVID-19 Pandemic: A Randomized Controlled Trial

2021 ◽  
Vol 18 (14) ◽  
pp. 7510
Author(s):  
Guillermo García Pérez de Sevilla ◽  
Olga Barceló Guido ◽  
María de la Paz De la Cruz ◽  
Ascensión Blanco Fernández ◽  
Lidia B. Alejo ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Effect Size ◽  
Exercise Intervention ◽  
Controlled Trial ◽  
Intervention Group ◽  
Nutrition Intervention ◽  
Sitting Time ◽  
Post Intervention ◽  
University Employees ◽  
Randomized Controlled

Healthy lifestyles should be encouraged in the workplace through the occupational health teams of the companies. The objective of the present study was to evaluate the adherence to a lifestyle intervention carried out in university employees during the COVID-19 pandemic and its impact on health-related quality of life (HrQoL). A randomized controlled trial following the CONSORT guidelines was performed, consisting of three supervised interventions lasting for 18 weeks: an educational intervention on healthy habits, a nutritional intervention, and a telematic aerobic and strength exercise intervention. Lifestyle and HrQoL were analyzed six months post-intervention to assess adherence. Twenty-three middle-aged participants completed the study. The intervention group significantly improved their lifestyle according to the Health Promoting Lifestyle Profile II questionnaire, especially in the categories of Health Responsibility, Physical Activity, and Nutrition, with a large effect size. Sitting time was reduced by 2.5 h per day, with a moderate effect size. Regarding HrQoL, the intervention group showed a clinically significant improvement in the Physical Component Summary. Despite the lockdown and the mobility restrictions caused by the COVID-19 pandemic, this intervention performed on university employees achieved adherence to a healthier lifestyle and improved their HrQoL, which is of great clinical relevance.

scholarly journals The Effect of Proprioceptive Neuromuscular Facilitation on Joint Position Sense: A Systematic Review

2020 ◽  
Vol 29 (4) ◽  
pp. 488-497 ◽  
Author(s):  
Hiroshi Takasaki ◽  
Yu Okubo ◽  
Shun Okuyama
Keyword(s):  
Randomized Controlled Trial ◽  
Effect Size ◽  
Methodological Quality ◽  
Controlled Trial ◽  
Position Sense ◽  
Joint Position Sense ◽  
Joint Position ◽  
Healthy Individuals ◽  
Randomized Controlled ◽  
Proprioceptive Neuromuscular Facilitation

Context: Accurate joint position sense (JPS) is necessary for effective motor learning and high performance in activities that require fine motor control. Proprioceptive neuromuscular facilitation (PNF) can be a promising intervention. Objective: To examine existing peer-reviewed original studies that have investigated the effect of PNF techniques on the JPS in terms of the methodological quality, PNF techniques, outcomes, and participant characteristics. Evidence Acquisition: A systematic literature search was performed using PubMed, EMBASE, MEDLINE, CINAHL, SocINDEX, Scopus, and Cochrane Library from inception to January 2018. The following inclusion criteria were used: (1) assessment of the JPS; (2) peer-reviewed original studies with a randomized controlled trial or quasi-randomized controlled trial design; (3) participants with musculoskeletal disorders or healthy individuals (ie, neither animal studies nor those involving neurological problems); and (4) no cointervention with PNF, except for warm-up procedures. The methodological quality was assessed using PEDro scale and 5 additional criteria. Effect size (η2) was calculated where a positive value indicated an increased JPS after PNF as compared with other approaches including the wait-and-see method. Evidence Synthesis: Nine studies were examined for their methodological quality, and only one study scored >6 on the PEDro scale. Positive and large effect size (η2 > .14) was detected in 2 studies where JPS of the knee with contract-relax and replication techniques was assessed in healthy individuals. However, the methodological quality of these studies was poor (PEDro scores of 3 and ≤5 in the total quality score out of 16, respectively). Conclusions: The current study did not find multiple studies with high methodological quality and similar PNF techniques, outcomes, and characteristics of participants. More high-quality studies are required to achieve a comprehensive understanding of the effect of PNF on the JPS.

Scapular exercise combined with cognitive functional therapy is more effective at reducing chronic neck pain and kinesiophobia than scapular exercise alone: a randomized controlled trial

2020 ◽  
Vol 34 (12) ◽  
pp. 1485-1496 ◽  
Author(s):  
Norollah Javdaneh ◽  
Amir Letafatkar ◽  
Sadredin Shojaedin ◽  
Malihe Hadadnezhad
Keyword(s):  
Randomized Controlled Trial ◽  
Neck Pain ◽  
Pain Intensity ◽  
Effect Size ◽  
Controlled Trial ◽  
Chronic Neck Pain ◽  
Secondary Outcome ◽  
Group Differences ◽  
Functional Therapy ◽  
Randomized Controlled

Objective: The aim of this study was to compare the effectiveness of scapular exercises alone and combined with cognitive functional therapy in treating patients with chronic neck pain and scapular downward rotation impairment. Design: Single-blind randomized controlled trial. Setting: Outpatient. Subjects: A total of 72 patients (20–45 years old) with chronic neck pain were studied. Intervention: Allocation was undertaken into three groups: scapular exercise ( n = 24), scapular exercise with cognitive functional therapy ( n = 24) and control ( n = 24) groups. Each programme lasted three times a week for six weeks. Main outcomes: The primary outcome measure was pain intensity measured by the visual analogue scale scores. The secondary outcome measures included kinesiophobia and muscles activity. Results: Statistically significant differences in pain intensity were found when multidisciplinary physiotherapy group including a cognitive functional approach was compared with the scapular exercise alone group at six weeks (effect size (95% CI) = −2.56 (−3.32 to −1.80); P = 0.019). Regarding kinesiophobia, a significant between-group difference was observed at six-week (effect size (95% CI) = −2.20 (−2.92 to −1.49); P = 0.005), with the superiority of effect in multidisciplinary physiotherapy group. A significant between-group differences was observed in muscle activity. Also, there were significant between-group differences favouring experimental groups versus control. Conclusion: A group-based multidisciplinary rehabilitation programme including scapular exercise plus cognitive functional therapy was superior to group-based scapular exercise alone for improving pain intensity, kinesiophobia and muscle activation in participants with chronic neck pain.

scholarly journals Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis

2020 ◽  
Vol 383 (12) ◽  
pp. 1117-1128 ◽  
Author(s):  
Richard Furie ◽  
Brad H. Rovin ◽  
Frédéric Houssiau ◽  
Ana Malvar ◽  
Y.K. Onno Teng ◽  
...  
Keyword(s):  
Randomized Controlled Trial ◽  
Lupus Nephritis ◽  
Controlled Trial ◽  
Randomized Controlled
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