scholarly journals An antibody-drug conjugate with intracellular drug release properties showing specific cytotoxicity against CD7-positive cells

2021 ◽  
pp. 106626
Author(s):  
Jing Zhang ◽  
Arvind Jain ◽  
Sabine Milhas ◽  
Daniel J. Williamson ◽  
Justyna Mysliwy ◽  
...  
Keyword(s):  
Drug Release ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Specific Cytotoxicity ◽  
Antibody Drug

Triggered Drug Release from an Antibody–Drug Conjugate Using Fast “Click-to-Release” Chemistry in Mice

2016 ◽  
Vol 27 (7) ◽  
pp. 1697-1706 ◽  
Author(s):  
Raffaella Rossin ◽  
Sander M. J. van Duijnhoven ◽  
Wolter ten Hoeve ◽  
Henk M. Janssen ◽  
Laurens H. J. Kleijn ◽  
...  
Keyword(s):  
Drug Release ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Triggered Drug Release ◽  
Antibody Drug

scholarly journals A poly-ADP-ribose polymer-based antibody-drug conjugate

2020 ◽  
Vol 11 (34) ◽  
pp. 9303-9308
Author(s):  
Xiaojing Shi ◽  
Xiao-Nan Zhang ◽  
Jingwen Chen ◽  
Qinqin Cheng ◽  
Hua Pei ◽  
...  
Keyword(s):  
Cancer Cells ◽  
Antibody Drug Conjugate ◽  
Tubulin Inhibitors ◽  
Drug Conjugate ◽  
Specific Cytotoxicity ◽  
Antibody Drug

Azido-functionalized poly-ADP-ribose (PAR) polymers were conjugated with anti-HER2 antibodies and tubulin inhibitors to generate a PAR polymer-based antibody-drug conjugate with potent and specific cytotoxicity toward HER2-expressing cancer cells.

scholarly journals High-Throughput, Multispecies, Parallelized Plasma Stability Assay for the Determination and Characterization of Antibody–Drug Conjugate Aggregation and Drug Release

ACS Omega ◽  
2017 ◽  
Vol 2 (8) ◽  
pp. 4207-4215 ◽  
Author(s):  
Kenneth R. Durbin ◽  
M. Shannon Nottoli ◽  
Nathaniel D. Catron ◽  
Nicole Richwine ◽  
Gary J. Jenkins
Keyword(s):  
Drug Release ◽  
High Throughput ◽  
Plasma Stability ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Author Correction: Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

2019 ◽  
Vol 10 (1) ◽  
Author(s):  
Raffaella Rossin ◽  
Ron M. Versteegen ◽  
Jeremy Wu ◽  
Alisher Khasanov ◽  
Hans J. Wessels ◽  
...  
Keyword(s):  
Drug Release ◽  
Antitumour Activity ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Triggered Drug Release ◽  
Antibody Drug

scholarly journals Tumor stroma–targeted antibody-drug conjugate triggers localized anticancer drug release

2018 ◽  
Vol 128 (7) ◽  
pp. 2927-2943 ◽  
Author(s):  
Christopher Szot ◽  
Saurabh Saha ◽  
Xiaoyan M. Zhang ◽  
Zhongyu Zhu ◽  
Mary Beth Hilton ◽  
...  
Keyword(s):  
Drug Release ◽  
Anticancer Drug ◽  
Tumor Stroma ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Antibody Drug

scholarly journals Chemically triggered drug release from an antibody-drug conjugate leads to potent antitumour activity in mice

2018 ◽  
Vol 9 (1) ◽  
Author(s):  
Raffaella Rossin ◽  
Ron M. Versteegen ◽  
Jeremy Wu ◽  
Alisher Khasanov ◽  
Hans J. Wessels ◽  
...  
Keyword(s):  
Drug Release ◽  
Antitumour Activity ◽  
Antibody Drug Conjugate ◽  
Drug Conjugate ◽  
Triggered Drug Release ◽  
Antibody Drug
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