Role of epigallocatechin gallate (EGCG) in the treatment of breast and prostate cancer

Life Sciences ◽  
2006 ◽  
Vol 79 (25) ◽  
pp. 2329-2336 ◽  
Author(s):  
Emma C. Stuart ◽  
Marissa J. Scandlyn ◽  
Rhonda J. Rosengren
Keyword(s):  
Prostate Cancer ◽  
Epigallocatechin Gallate ◽  
Breast And Prostate Cancer

scholarly journals Role of Curcumin and (−)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review

Cancers ◽  
2020 ◽  
Vol 12 (7) ◽  
pp. 1801 ◽  
Author(s):  
Ludwika Piwowarczyk ◽  
Maciej Stawny ◽  
Dariusz T. Mlynarczyk ◽  
Izabela Muszalska-Kolos ◽  
Tomasz Goslinski ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Epigallocatechin Gallate ◽  
Therapeutic Approaches ◽  
Promising Candidate ◽  
Supportive Role ◽  
Cell Cycle Inhibition ◽  
Biochemical Mechanisms ◽  
Breast And Prostate Cancer ◽  
Treatment Of Obesity

The incidence of bladder cancer (BC) is increasing, and although current therapeutic approaches are effective in many cases, recurrence of BC is common. Therefore, it seems necessary to search not only for novel therapeutic approaches, but also for new therapeutic agents. Natural polyphenols, such as curcumin (CUR) and epigallocatechin gallate (EGCG), possess remarkable antitumor activity. Their biochemical mechanisms of action include regulation of signaling pathways, modeling of proteins involved in apoptosis and cell cycle inhibition, angiogenesis, and the proliferation, migration and adhesion of tumor cells. Both compounds also present antioxidant, anti-inflammatory, antibacterial and antiviral properties. CUR has been considered a promising candidate for the treatment of cystic fibrosis, Alzheimer’s disease or malaria, whereas EGCG can play a supportive role in the treatment of obesity, metabolic and neurodegenerative diseases. The review summarizes the latest research on the role of CUR and EGCG in the treatment of BC. In particular, the effects of CUR and EGCG, and their prospects for use in BC therapy, their inhibition of cancer development and their prevention of multidrug resistance, are described. The literature’s data indicate the possibility of achieving the effect of synergism of both polyphenols in BC therapy, which has been observed so far in the treatment of ovarian, breast and prostate cancer.

scholarly journals Disrupted sleep in breast and prostate cancer patients undergoing radiation therapy: the role of coping processes

2009 ◽  
Vol 19 (7) ◽  
pp. 767-776 ◽  
Author(s):  
KaMala S. Thomas ◽  
Julienne Bower ◽  
Michael A. Hoyt ◽  
Saviz Sepah
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Coping Processes ◽  
Breast And Prostate Cancer

Role of Apoptosis and its Modulation by Bcl-2 Family Members in Breast and Prostate Cancer

2003 ◽  
pp. 353-372
Author(s):  
Venil N. Sumantran ◽  
David R. Beidler ◽  
Max S. Wicha
Keyword(s):  
Prostate Cancer ◽  
Family Members ◽  
Breast And Prostate Cancer

Clinical role of proton magnetic resonance spectroscopy in oncology: brain, breast, and prostate cancer

2006 ◽  
Vol 7 (10) ◽  
pp. 859-868 ◽  
Author(s):  
Lester Kwock ◽  
J Keith Smith ◽  
Mauricio Castillo ◽  
Matthew G Ewend ◽  
Frances Collichio ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Magnetic Resonance ◽  
Magnetic Resonance Spectroscopy ◽  
Proton Magnetic Resonance ◽  
Proton Magnetic Resonance Spectroscopy ◽  
Resonance Spectroscopy ◽  
Clinical Role ◽  
Breast And Prostate Cancer

scholarly journals Analysis of expression of chorionic gonadotrophin transcripts in prostate cancer by quantitative Taqman and a modified molecular beacon RT-PCR

2002 ◽  
Vol 172 (3) ◽  
pp. 489-495 ◽  
Author(s):  
PN Span ◽  
CM Thomas ◽  
JJ Heuvel ◽  
RR Bosch ◽  
JA Schalken ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Normal Tissue ◽  
Molecular Beacon ◽  
Chorionic Gonadotrophin ◽  
Neuroendocrine Cells ◽  
Rt Pcr ◽  
Homologous Genes ◽  
Breast And Prostate Cancer ◽  
Modified Molecular Beacon

Expression of human chorionic gonadotrophin (hCG) is associated with trophoblastic, testicular and other malignancies such as bladder, pancreatic, cervical, breast and prostate cancer. In the prostate, however, hCG expression, associated with neuroendocrine cells, is also found in normal tissue. Of the six highly homologous genes that all encode the beta-subunit of hCG, the beta 7 gene is reportedly the only gene expressed in several non-transformed tissues. The beta 3, 5 and 8 genes would be variably expressed in malignant tissue and placenta, but not in normal tissue. To assess to what extent this expression difference can also be found in the prostate, we compared the levels of the different hCG beta transcripts in concurrent normal and cancerous prostate tissues obtained from 17 patients. To this end, we developed a Taqman real-time fluorescent RT-PCR assay for hCG beta, and a quantitative assay specific for the beta 3, 5 and 8 genes, modified from the molecular beacon principle. This latter assay proved highly specific and capable of reliably distinguishing between these hCG beta transcripts that differ in only one nucleotide. Surprisingly, median expression levels of hCG beta were lower in prostate cancer when compared with normal tissue from the same patient. In contrast, hCG beta 3, 5 and 8 transcripts were found in normal tissue and did not differ in prostate cancer, arguing against a specific role of these transcripts in the development of prostate cancer.

Abstract 3517: Role of primary cilia in breast and prostate cancer

2014 ◽  
Author(s):  
Nadia B. Hassounah ◽  
Martha Nunez ◽  
Raymond Nagle ◽  
Kimberly M. McDermott
Keyword(s):  
Prostate Cancer ◽  
Primary Cilia ◽  
Breast And Prostate Cancer

Role of Apoptosis and its Modulation by Bcl-2 Family Members in Breast and Prostate Cancer

2000 ◽  
pp. 353-371
Author(s):  
Venil N. Sumantran ◽  
David R. Beidler ◽  
Max S. Wicha
Keyword(s):  
Prostate Cancer ◽  
Family Members ◽  
Breast And Prostate Cancer

scholarly journals The Role of 18F-Sodium Fluoride PET/CT Bone Scans in the Diagnosis of Metastatic Bone Disease from Breast and Prostate Cancer

2016 ◽  
Vol 44 (4) ◽  
pp. 217-222 ◽  
Author(s):  
R. K. Kulshrestha ◽  
S. Vinjamuri ◽  
A. England ◽  
J. Nightingale ◽  
P. Hogg
Keyword(s):  
Prostate Cancer ◽  
Sodium Fluoride ◽  
Bone Disease ◽  
Metastatic Bone Disease ◽  
Pet Ct ◽  
Breast And Prostate Cancer ◽  
Bone Scans
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