Role of Matrix Metalloproteinases in Bone Metastasis from Human Breast and Prostate Cancer

2004 ◽  
pp. 241-276
Author(s):  
Wilhelmina C. M. Duivenvoorden ◽  
Gurmit Singh
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Matrix Metalloproteinases ◽  
Human Breast ◽  
Breast And Prostate Cancer

Proliferative effect of whey from cows’ milk varying in phyto-oestrogens in human breast and prostate cancer cells

2012 ◽  
Vol 79 (2) ◽  
pp. 143-149 ◽  
Author(s):  
Tina S. Nielsen ◽  
Annika Höjer ◽  
Anne-Maj Gustavsson ◽  
Jens Hansen-Møller ◽  
Stig Purup
Keyword(s):  
Prostate Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Dietary Treatment ◽  
Human Breast ◽  
Prostate Cancer Cells ◽  
Proliferative Effect ◽  
Significant Difference ◽  
Breast And Prostate Cancer ◽  
Mcf 7

Intake of dietary phyto-oestrogens has received a great deal of attention owing to their potential influence on hormone-sensitive cancers such as breast and prostate cancer. Cows’ milk contains phyto-oestrogens and the content varies according to the composition of the feed and the type and amount of legumes used. In this study we evaluated the proliferative effect of milk (whey) with different phyto-oestrogen content in human breast (MCF-7) and prostate cancer cells (PC-3). Milk was obtained from cows fed either a birdsfoot trefoil-timothy silage based ration (B1) or two different red clover silage based diets (R1 and R2) resulting in total phyto-oestrogen contents of 403, 1659 and 1434 ng/ml for the B1, R1 and R2 diets, respectively. Whey was produced from the milk and added to cell culture medium in concentrations up to 10% for MCF-7 cells and 5% for PC-3 cells. Cell proliferation was measured fluorometrically after 7 d for MCF-7 cells and 5 d for PC-3 cells. There was no significant difference in the proliferative effect of whey from the different dietary treatments at any of the whey concentrations tested. An anti-proliferative effect (P<0·01) of 5 and 10% whey was seen when tested in the presence of 10 pmoestradiol in the medium. This effect was independent of dietary treatment of cows. Whey induced a significant (P<0·01) proliferative response in PC-3 cells independent of dietary treatment. Purified equol in concentrations similar to equol concentrations in milk decreased PC-3 cell proliferation, and therefore the stimulatory effect of whey in PC-3 cells is believed to be mediated by other bioactives than equol. In conclusion, our results suggest that using whey in these proliferation assays, it was not possible to discriminate between milk with high or low levels of phyto-oestrogens.

Caspase-dependent apoptosis induced by two synthetic halogenated flavanones, 3′,7-dichloroflavanone and 3′,6-dichloroflavanone, on human breast and prostate cancer cells

2017 ◽  
Vol 54 (2) ◽  
pp. 136-146 ◽  
Author(s):  
Maliheh Safavi ◽  
Raheleh Shakeri ◽  
Sussan Kabudanian Ardestani ◽  
Jamshid Davoodi ◽  
Soheila Ajdary ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cancer Cells ◽  
Human Breast ◽  
Prostate Cancer Cells ◽  
Breast And Prostate Cancer

scholarly journals Potential role of the OPG/RANK/RANKL axis in prostate cancer invasion and bone metastasis

2014 ◽  
Vol 32 (6) ◽  
pp. 2605-2611 ◽  
Author(s):  
XIAOMING LI ◽  
YAOMING LIU ◽  
BIN WU ◽  
ZHILONG DONG ◽  
YICHEN WANG ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Bone Metastasis ◽  
Potential Role ◽  
Cancer Invasion
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