CRTH2 antagonist, CT‑133, effectively alleviates cigarette smoke-induced acute lung injury

Life Sciences ◽  
2019 ◽  
Vol 216 ◽  
pp. 156-167 ◽  
Author(s):  
Musaddique Hussain ◽  
Chengyun Xu ◽  
Minli Yao ◽  
Qin Zhang ◽  
Junsong Wu ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cigarette Smoke

Gene silencing of receptor-interacting protein 2 protects against cigarette smoke-induced acute lung injury

2019 ◽  
Vol 139 ◽  
pp. 560-568 ◽  
Author(s):  
Jinrui Dong ◽  
Wupeng Liao ◽  
Lay Hong Tan ◽  
Amy Yong ◽  
Wen Yan Peh ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Gene Silencing ◽  
Cigarette Smoke ◽  
Interacting Protein

Effects of Eucalyptol in respiratory system mechanics on acute lung injury after exposure to short-term cigarette smoke

2019 ◽  
Vol 266 ◽  
pp. 33-38 ◽  
Author(s):  
Fladimir de Lima Gondim ◽  
Daniel Silveira Serra ◽  
Francisco Sales Ávila Cavalcante
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cigarette Smoke ◽  
Respiratory System ◽  
Short Term ◽  
Respiratory System Mechanics

Apple polyphenol protects against cigarette smoke-induced acute lung injury

Nutrition ◽  
2013 ◽  
Vol 29 (1) ◽  
pp. 235-243 ◽  
Author(s):  
Meng-Jing Bao ◽  
Jian Shen ◽  
Yong-Liang Jia ◽  
Fen-Fen Li ◽  
Wen-Jiang Ma ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cigarette Smoke

scholarly journals Cigarette smoke exposure worsens acute lung injury in antibiotic-treated bacterial pneumonia in mice

2018 ◽  
Vol 315 (1) ◽  
pp. L25-L40 ◽  
Author(s):  
Jeffrey E. Gotts ◽  
Lauren Chun ◽  
Jason Abbott ◽  
Xiaohui Fang ◽  
Naoki Takasaka ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cigarette Smoke ◽  
Clinical Relevance ◽  
Bacterial Pneumonia ◽  
Pneumococcal Infection ◽  
Whole Body ◽  
Cigarette Smoke Exposure ◽  
Surfactant Protein D ◽  
Systemic Spread

Evidence is accumulating that exposure to cigarette smoke (CS) increases the risk of developing acute respiratory distress syndrome (ARDS). Streptococcus pneumoniae is the most common cause of bacterial pneumonia, which in turn is the leading cause of ARDS. Chronic smokers have increased rates of pneumococcal colonization and develop more severe pneumococcal pneumonia than nonsmokers; yet mechanistic connections between CS exposure, bacterial pneumonia, and ARDS pathogenesis remain relatively unexplored. We exposed mice to 3 wk of moderate whole body CS or air, followed by intranasal inoculation with an invasive serotype of S. pneumoniae. CS exposure alone caused no detectable lung injury or bronchoalveolar lavage (BAL) inflammation. During pneumococcal infection, CS-exposed mice had greater survival than air-exposed mice, in association with reduced systemic spread of bacteria from the lungs. However, when mice were treated with antibiotics after infection to improve clinical relevance, the survival benefit was lost, and CS-exposed mice had more pulmonary edema, increased numbers of BAL monocytes, and elevated monocyte and lymphocyte chemokines. CS-exposed antibiotic-treated mice also had higher serum surfactant protein D and angiopoietin-2, consistent with more severe lung epithelial and endothelial injury. The results indicate that acute CS exposure enhances the recruitment of immune cells to the lung during bacterial pneumonia, an effect that may provide microbiological benefit but simultaneously exposes the mice to more severe inflammatory lung injury. The inclusion of antibiotic treatment in preclinical studies of acute lung injury in bacterial pneumonia may enhance clinical relevance, particularly for future studies of current or emerging tobacco products.

scholarly journals Inhalation of ambroxol inhibits cigarette smoke-induced acute lung injury in a mouse model by inhibiting the Erk pathway

2016 ◽  
Vol 33 ◽  
pp. 90-98 ◽  
Author(s):  
Ling-tian Ge ◽  
Ya-nan Liu ◽  
Xi-xi Lin ◽  
Hui-juan Shen ◽  
Yong-liang Jia ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Mouse Model ◽  
Cigarette Smoke ◽  
Erk Pathway

Constitutive transgenic alpha-Klotho overexpression enhances resilience to and recovery from murine acute lung injury

2021 ◽  
Author(s):  
Joshuah M Gagan ◽  
Khoa Cao ◽  
Yu-An Zhang ◽  
Jianning Zhang ◽  
Taylor L Davidson ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Epithelial Cells ◽  
Lung Injury ◽  
Cigarette Smoke ◽  
Lung Epithelial Cells ◽  
Lung Damage ◽  
Dna Breaks ◽  
Age Related ◽  
Lung Epithelial

Aims: Normal lungs do not express alpha-Klotho (Klotho) protein but derive cytoprotection from circulating soluble Klotho. It is unclear whether chronic supranormal Klotho levels confer additional benefit. To address this, we tested the age-related effects of Klotho overexpression on acute lung injury (ALI) and recovery. Methods: Transgenic Klotho-overexpressing (Tg-Kl) and wild-type (WT) mice (2 and 6 months old) were exposed to hyperoxia (95% O2; 72 h) then returned to normoxia (21% O2; 24 h) (Hx-R). Control mice were kept in normoxia. Renal and serum Klotho, lung histology, and bronchoalveolar lavage fluid oxidative damage markers were assessed. Effects of hyperoxia were tested in human embryonic kidney cells stably expressing Klotho. A549 lung epithelial cells transfected with Klotho cDNA or vector were exposed to cigarette smoke; lactate dehydrogenase and double-strand DNA breaks were measured. Results: Serum Klotho decreased with age. Hyperoxia suppressed renal Klotho at both ages and serum Klotho at 2-months of age. Tg-Kl mice at both ages and 2-months-old WT mice survived Hx-R; 6-months-old Tg-Kl mice showed lower lung damage than age-matched WT mice. Hyperoxia directly inhibited Klotho expression and release in vitro; Klotho transfection attenuated cigarette smoke-induced cytotoxicity and DNA double-strand breaks in lung epithelial cells. Conclusions: Young animals with chronic high baseline Klotho expression are more resistant to ALI. Chronic constitutive Klotho overexpression in older Tg-Kl animals attenuates hyperoxia-induced lung damage and improves survival and short-term recovery despite an acute reduction in serum Klotho level during injury. We conclude that chronic enhancement of Klotho expression increases resilience to ALI.

Quercetin Attenuates Acute Lung Injury Caused by Cigarette Smoke Both In Vitro and In Vivo

2020 ◽  
Vol 17 (2) ◽  
pp. 205-214 ◽  
Author(s):  
Natália Pereira da Silva Araújo ◽  
Natália Alves de Matos ◽  
Suianne Leticia Antunes Mota ◽  
Ana Beatriz Farias de Souza ◽  
Sílvia Dantas Cangussú ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Cigarette Smoke
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