Scleraxis is required for normal heart valve formation in vivo

2008 ◽  
Vol 27 ◽  
pp. 36-37
Author(s):  
Agata K. Levay ◽  
Jacqueline D. Peacock ◽  
Yinhui Lu ◽  
Manuel Koch ◽  
Robert B. Hinton ◽  
...  
Keyword(s):  
Heart Valve ◽  
Normal Heart ◽  
Valve Formation

scholarly journals Muscleblind-like 1 is required for normal heart valve development in vivo

2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Ryan J. Coram ◽  
Samantha J. Stillwagon ◽  
Anuradha Guggilam ◽  
Michael W. Jenkins ◽  
Maurice S. Swanson ◽  
...  
Keyword(s):  
Heart Valve ◽  
Normal Heart ◽  
Valve Development

scholarly journals Mechanically activated piezo channels modulate outflow tract valve development through the Yap1 and Klf2-Notch signaling axis

eLife ◽  
2019 ◽  
Vol 8 ◽  
Author(s):  
Anne-Laure Duchemin ◽  
Hélène Vignes ◽  
Julien Vermot
Keyword(s):  
Notch Signaling ◽  
Heart Valve ◽  
Notch Signaling Pathway ◽  
Outflow Tract ◽  
Mechanical Forces ◽  
Valve Development ◽  
Signaling Axis ◽  
Cell Layers ◽  
Valve Formation

Mechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are important factors modulating these pathways. In addition, live reporters reveal that Piezo controls Klf2 and Notch activity in the endothelium and Yap1 localization in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

scholarly journals Mechanically activated Piezo channels control outflow tract valve development through Yap1 and Klf2-Notch signaling axis

2019 ◽  
Author(s):  
Anne Laure Duchemin ◽  
Hélène Vignes ◽  
Julien Vermot
Keyword(s):  
Notch Signaling ◽  
Heart Valve ◽  
Notch Signaling Pathway ◽  
Outflow Tract ◽  
Mechanical Forces ◽  
Valve Development ◽  
Signaling Axis ◽  
Cell Layers ◽  
Valve Formation

AbstractMechanical forces are well known for modulating heart valve developmental programs. Yet, it is still unclear how genetic programs and mechanosensation interact during heart valve development. Here, we assessed the mechanosensitive pathways involved during zebrafish outflow tract (OFT) valve development in vivo. Our results show that the hippo effector Yap1, Klf2, and the Notch signaling pathway are all essential for OFT valve morphogenesis in response to mechanical forces, albeit active in different cell layers. Furthermore, we show that Piezo and TRP mechanosensitive channels are essential for regulating these pathways. In addition, live reporters reveal that piezo controls Klf2 and Notch activity in the endothelium and Yap1 expression in the smooth muscle progenitors to coordinate OFT valve morphogenesis. Together, this work identifies a unique morphogenetic program during OFT valve formation and places Piezo as a central modulator of the cell response to forces in this process.

scholarly journals Scleraxis Is Required for Cell Lineage Differentiation and Extracellular Matrix Remodeling During Murine Heart Valve Formation In Vivo

2008 ◽  
Vol 103 (9) ◽  
pp. 948-956 ◽  
Author(s):  
Agata K. Levay ◽  
Jacqueline D. Peacock ◽  
Yinhui Lu ◽  
Manuel Koch ◽  
Robert B. Hinton ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Heart Valve ◽  
Cell Lineage ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling ◽  
Lineage Differentiation ◽  
Valve Formation

In vivo study of the effects of cryopreservation on heart valve xenotransplantation

2005 ◽  
Vol 14 (2) ◽  
pp. 70-79 ◽  
Author(s):  
Shigeo Nagasaka ◽  
Shigeki Taniguchi ◽  
Yoshio Nakayama ◽  
Hidehito Sakaguchi ◽  
Kazuhiko Nishizaki ◽  
...  
Keyword(s):  
Heart Valve ◽  
In Vivo Study

scholarly journals In vivo cellularization of a cross-linked matrix by intraperitoneal implantation: a new tool in heart valve tissue engineering

2007 ◽  
Vol 28 (11) ◽  
pp. 1389-1396 ◽  
Author(s):  
G. De Visscher ◽  
I. Vranken ◽  
A. Lebacq ◽  
C. Van Kerrebroeck ◽  
J. Ganame ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Heart Valve ◽  
Valve Tissue ◽  
Heart Valve Tissue ◽  
Heart Valve Tissue Engineering

In vivo Platelet Release Reaction in Patients with Heart Valve Prosthesis

1980 ◽  
Vol 9 (5) ◽  
pp. 263-275
Author(s):  
G. Cella ◽  
L. Schivazappa ◽  
A. Casonato ◽  
L.G. Molaro ◽  
A. Girolami ◽  
...  
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Release Reaction ◽  
Platelet Release

scholarly journals Design, development, testing at ISO standards and in vivo feasibility study of a novel polymeric heart valve prosthesis

2020 ◽  
Vol 8 (16) ◽  
pp. 4467-4480
Author(s):  
Joanna R. Stasiak ◽  
Marta Serrani ◽  
Eugenia Biral ◽  
James V. Taylor ◽  
Azfar G. Zaman ◽  
...  
Keyword(s):  
Heart Valve ◽  
Feasibility Study ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
Design Development ◽  
Iso Standards ◽  
Bench Testing ◽  
Bioprosthetic Valves

A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.

In Vivo Evaluation of the Lillehei-Kaster Heart Valve Prosthesis

1976 ◽  
Vol 22 (3) ◽  
pp. 213-220 ◽  
Author(s):  
U. Sigwart ◽  
H. Schmidt ◽  
U. Gleichmann ◽  
H.G. Borst
Keyword(s):  
Heart Valve ◽  
Heart Valve Prosthesis ◽  
Valve Prosthesis ◽  
In Vivo Evaluation
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