heart valve prosthesis
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2021 ◽  
Vol 7 (2) ◽  
pp. 13-16
Author(s):  
Sugat Ratna Tuladhar ◽  
Michael Teske ◽  
Stefan Oschatz ◽  
Sabine Illner ◽  
Tobias Schilling ◽  
...  

Abstract Heart valve tissue engineering aims at creating living valves through colonization of scaffolds with patient’s own cells. Various cell sources have been explored focusing mainly on endothelialization of the scaffold surface. Endothelial like cells, such as endothelial progenitor cells (EPCs), which can be isolated from peripheral blood or bone marrow could be a suitable option. In this study we investigated cell colonization potential of ovine EPCs (OEPCs) on thermoplastic silicone-based polyurethane (TSPU) polymer scaffolds. TSPU nonwovens with and without vascular endothelial growth factor (VEGF) functionalization were used. SEM images showed that by day 3 the cells were growing as patches on the surface of both polymer groups. The cell patches continued growing and started covering more of the nonwoven surface. On day 7 the cells had almost covered the scaffold surface. The cells were more uniformly distributed as monolayer on the functionalized TSPU compared to the non-functionalized nonwovens. Live/Dead staining provided bright green fluorescence on the samples, indicating metabolically active alive cells. These static cell seeding experiments demonstrated that functionalized TPSU nonwovens support endothelialization. The feasibility of TPSU nonwovens as heart valve prosthesis scaffold could be further explored with animal studies in an ovine model.





JTCVS Open ◽  
2021 ◽  
Author(s):  
Tim Schaller ◽  
Michael Scharfschwerdt ◽  
Kathrin Schubert ◽  
Cornelia Prinz ◽  
Ulrich Lembke ◽  
...  


2021 ◽  
Vol 5 (sup1) ◽  
pp. 2-2
Author(s):  
Bart Meuris ◽  
Lucas Van Hoof ◽  
Wilm Decré ◽  
Marie Lamberigts ◽  
Tom Langenaeken ◽  
...  


Author(s):  
Muthukumar Sundaram ◽  
Aayush Poddar ◽  
Ancy Robinson ◽  
Soundaravalli Balakrishnan ◽  
Muralidharan Srinivasan ◽  
...  


2020 ◽  
Vol 4 (sup1) ◽  
pp. 103-104
Author(s):  
Maryam H. Abyaneh ◽  
David Kalfa ◽  
Richard Li ◽  
Abdul Barakat ◽  
Giovanni Ferrari ◽  
...  


2020 ◽  
Vol 8 (16) ◽  
pp. 4467-4480
Author(s):  
Joanna R. Stasiak ◽  
Marta Serrani ◽  
Eugenia Biral ◽  
James V. Taylor ◽  
Azfar G. Zaman ◽  
...  

A novel polymeric heart valve shows durability equivalent to 25 years in accelerated bench testing, in vitro hydrodynamics equivalent to existing bioprosthetic valves; and good performance in a small acute feasibility study in sheep.



2020 ◽  
Vol 159 (1) ◽  
pp. 74-83.e4 ◽  
Author(s):  
Eva Havers-Borgersen ◽  
Jawad H. Butt ◽  
Naja E. Vinding ◽  
Christian Torp-Pedersen ◽  
Gunnar Gislason ◽  
...  




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