Effects of periodic intake of drugs of abuse (morphine) on HIV dynamics: Mathematical model and analysis

2020 ◽  
Vol 326 ◽  
pp. 108395 ◽  
Author(s):  
Jones M. Mutua ◽  
Feng-Bin Wang ◽  
Naveen K. Vaidya
Keyword(s):  
Mathematical Model ◽  
Drugs Of Abuse ◽  
Hiv Dynamics

A numerical algorithm for constructing an individual mathematical model of HIV dynamics at cellular level

2018 ◽  
Vol 26 (6) ◽  
pp. 859-873 ◽  
Author(s):  
H. Thomas Banks ◽  
Sergey I. Kabanikhin ◽  
Olga I. Krivorotko ◽  
Darya V. Yermolenko
Keyword(s):  
Experimental Data ◽  
Mathematical Model ◽  
Inverse Problem ◽  
Cellular Level ◽  
Free Virus ◽  
Hiv Dynamics ◽  
Infection Parameters ◽  
Simulation Results ◽  
The Mathematical Model ◽  
Fixed Times

Abstract In this paper a problem of specifying HIV-infection parameters and immune response using additional measurements of the concentrations of the T-lymphocytes, the free virus and the immune effectors at fixed times for a mathematical model of HIV dynamics is investigated numerically. The problem of the parameter specifying of the mathematical model (an inverse problem) is reduced to a problem of minimizing an objective function describing the deviation of the simulation results from the experimental data. A genetic algorithm for solving the least squares function minimization problem is implemented and investigated. The results of a numerical solution of the inverse problem are analyzed.

scholarly journals Bifurcations of a mathematical model for HIV dynamics

2016 ◽  
Vol 434 (1) ◽  
pp. 837-857 ◽  
Author(s):  
Jianfeng Luo ◽  
Wendi Wang ◽  
Hongyan Chen ◽  
Rui Fu
Keyword(s):  
Mathematical Model ◽  
Hiv Dynamics

The Use of Prescription Drugs and Drugs of Abuse for Neuroenhancement in Europe

2015 ◽  
Vol 20 (3) ◽  
pp. 155-166 ◽  
Author(s):  
Larissa J. Maier ◽  
Michael P. Schaub
Keyword(s):  
Prescription Drugs ◽  
Illicit Drugs ◽  
Adverse Reactions ◽  
Low Dose ◽  
Drugs Of Abuse ◽  
Mental Performance ◽  
Or Education ◽  
Learning Techniques ◽  
Monitoring The Future ◽  
Definition Of

Abstract. Pharmacological neuroenhancement, defined as the misuse of prescription drugs, illicit drugs, or alcohol for the purpose of enhancing cognition, mood, or prosocial behavior, is not widespread in Europe – nevertheless, it does occur. Thus far, no drug has been proven as safe and effective for cognitive enhancement in otherwise healthy individuals. European studies have investigated the misuse of prescription and illicit stimulants to increase cognitive performance as well as the use of tranquilizers, alcohol, and cannabis to cope with stress related to work or education. Young people in educational settings report pharmacological neuroenhancement more frequently than those in other settings. Although the regular use of drugs for neuroenhancement is not common in Europe, the irregular and low-dose usage of neuroenhancers might cause adverse reactions. Previous studies have revealed that obtaining adequate amounts of sleep and using successful learning techniques effectively improve mental performance, whereas pharmacological neuroenhancement is associated with ambiguous effects. Therefore, non-substance-related alternatives should be promoted to cope with stressful situations. This paper reviews the recent research on pharmacological neuroenhancement in Europe, develops a clear definition of the substances used, and formulates recommendations for practitioners regarding how to react to requests for neuroenhancement drug prescriptions. We conclude that monitoring the future development of pharmacological neuroenhancement in Europe is important to provide effective preventive measures when required. Furthermore, substance use to cope with stress related to work or education should be studied in depth because it is likely more prevalent and dangerous than direct neuroenhancement.

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