Is DNA repair controlled by a biological logic circuit?

The possible utilization of biological logic circuit(s) in the integration and regulation of DNA repair is discussed. The author believes this mode of regulation likely applies to many other areas of cell biology; however, there are currently more experimental data to support its involvement in the control of DNA repair. Sequential logic processes always require a clock to orchestrate the orderly processing of events. In the proposed hypothesis, the pulses in the expression of p53 serve this function. Given the many advantages of logic type control, one would expect that in the course of ~ 3 billion years of evolution, where single cell life forms were likely the only forms of life, a biological logic type control system would have evolved to control at least some biological processes. Several other required components in addition to the ‘clock’ have been identified, such as; a method to temporarily inactivate repair processes when they are not required (e.g. the reversible inactivation of MGMT, a suicide repair protein, by phosphorylation); this prevents complex DNA repair systems with potentially overlapping repair functions from interfering with each other.

The biological Maxwell's demons: exploring ideas about the information processing in biological systems

This work is based on ideas supported by some of the biologists who discovered foundational facts of twentieth-century biology and who argued that Maxwell's demons are physically implemented by biological devices. In particular, JBS Haldane first, and later J. Monod, A, Lwoff and F. Jacob argued that enzymes and molecular receptors implemented Maxwell's demons that operate in systems far removed from thermodynamic equilibrium and that were responsible for creating the biological order. Later, these ideas were extended to other biological processes. In this article, we argue that these biological Maxwell's demons (BMD) are systems that have information processing capabilities that allow them to select their inputs and direct their outputs toward targets. In this context, we propose the idea that these BMD are information catalysts in which the processed information has broad thermodynamic consequences.

Geometry and symmetry in biochemical reaction systems

Complex systems of intracellular biochemical reactions have a central role in regulating cell identities and functions. Biochemical reaction systems are typically studied using the language and tools of graph theory. However, graph representations only describe pairwise interactions between molecular species and so are not well suited to modelling complex sets of reactions that may involve numerous reactants and/or products. Here, we make use of a recently developed hypergraph theory of chemical reactions that naturally allows for higher-order interactions to explore the geometry and quantify functional redundancy in biochemical reactions systems. Our results constitute a general theory of automorphisms for oriented hypergraphs and describe the effect of automorphism group structure on hypergraph Laplacian spectra.