Genetically modified mouse models in studies of luteinising hormone action

2006 ◽  
Vol 252 (1-2) ◽  
pp. 126-135 ◽  
Author(s):  
Ilpo Huhtaniemi ◽  
Petteri Ahtiainen ◽  
Tomi Pakarainen ◽  
Susana B. Rulli ◽  
Fu-Ping Zhang ◽  
...  
Keyword(s):  
Mouse Models ◽  
Luteinising Hormone ◽  
Genetically Modified ◽  
Hormone Action

Hepatic miRNA expression profiling in genetically modified mouse models of different atherosclerosis susceptibility

2016 ◽  
Vol 252 ◽  
pp. e206-e207
Author(s):  
S. Manzini ◽  
M. Busnelli ◽  
M. Chiara ◽  
C. Parolini ◽  
F. Dellera ◽  
...  
Keyword(s):  
Mouse Models ◽  
Mirna Expression ◽  
Expression Profiling ◽  
Genetically Modified ◽  
Mirna Expression Profiling

Genetically modified mouse models in cancer studies

2008 ◽  
Vol 10 (12) ◽  
pp. 794-803 ◽  
Author(s):  
Javier Santos ◽  
Pablo Fernández-Navarro ◽  
María Villa-Morales ◽  
Laura González-Sánchez ◽  
José Fernández-Piqueras
Keyword(s):  
Mouse Models ◽  
Genetically Modified ◽  
Cancer Studies

What Can Transgenic and Gene-targeted Mouse Models Teach Us about Salivary Gland Physiology?

2000 ◽  
Vol 14 (1) ◽  
pp. 5-11 ◽  
Author(s):  
J.E. Melvin ◽  
H.-V. Nguyen ◽  
R.L. Evans ◽  
G.E. Shull
Keyword(s):  
Salivary Gland ◽  
Mouse Models ◽  
Recombinant Dna ◽  
Genetically Modified ◽  
Cell Physiology ◽  
Specific Expression ◽  
Disease States ◽  
Salivary Gland Secretion ◽  
Genetically Modified Mice ◽  
Gland Function

Thousands of genetically modified mice have been developed since the first reports of stable expression of recombinant DNA in this species nearly 20 years ago. This mammalian model system has revolutionized the study of whole-animal, organ, and cell physiology. Transgenic and gene-targeted mice have been widely used to characterize salivary-gland-specific expression and to identify genes associated with tumorigenesis. Moreover, several of these mouse lines have proved to be useful models of salivary gland disease related to impaired immunology, i.e., Sjogren's syndrome, and disease states associated with pathogens. Despite the availability of genetically modified mice, few investigators have taken advantage of this resource to better their understanding of salivary gland function as it relates to the production of saliva. In this article, we describe the methods used to generate transgenic and gene-targeted mice and provide an overview of the advantages of and potential difficulties with these models. Finally, using these mouse models, we discuss the advances made in our understanding of the salivary gland secretion process.

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