PCA exchange method for compensation of error sources in pressure balance calibration

The lack of simple, efficient [18F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [18F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated 18F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol–1) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [18F]fluorosulfate is demonstrated by the in vivo tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).

Download Full-text

Faculty Opinions recommendation of An Effective Deuterium Exchange Method for Neutron Crystal Structure Analysis with Unfolding-Refolding Processes.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726510152.793521014 ◽

2016 ◽

Author(s):

Andrey Kovalevsky ◽

Mayank Aggarwal

Keyword(s):

Crystal Structure ◽

Structure Analysis ◽

Crystal Structure Analysis ◽

Deuterium Exchange ◽

Exchange Method

Download Full-text

ZrO2 : Eu3+ NANOCRYSTAL FABRICATION AND ITS LUMINESCENCE PROPERTIES BY ION EXCHANGE METHOD

ACTA METALLURGICA SINICA ◽

10.3724/sp.j.1037.2009.00118 ◽

2010 ◽

Vol 2010 (2) ◽

pp. 179-183 ◽

Cited By ~ 1

Author(s):

Ren SHA ◽

Xigui WANG ◽

Xia LI

Keyword(s):

Ion Exchange ◽

Luminescence Properties ◽

Exchange Method ◽

Ion Exchange Method

Download Full-text

Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment

Revista de Chimie ◽

10.37358/rc.20.3.8007 ◽

2001 ◽

Vol 71 (3) ◽

pp. 342-349

Author(s):

Lucian Eva ◽

Letitia Doina Duceac ◽

Liviu Stafie ◽

Constantin Marcu ◽

Geta Mitrea ◽

...

Keyword(s):

Chemical Characterization ◽

Advanced Characterization ◽

Generation Cephalosporin ◽

Fourth Generation ◽

Exchange Method ◽

Physico Chemical ◽

Life Threatening ◽

Double Hydroxide ◽

Double Hydroxides

The fourth generation cephalosporin antibacterial agent, cefepime, was loaded into layered double hydroxides for enhancing antibiotic efficiency, reducing side effects, as well as achieving the sustained release property. The intercalation of antibiotic into the inter-gallery of ZnAl-layered double hydroxide (LDH) was carried out using ion exchange method, by this constituting a nano-sized organic-inorganic hybrid material for a controlled release novel formulation. Although cefepime is a broad spectrum antibiotic, it has various adverse effects and a significant degradation rate. Thus, the preparation and physico-chemical characterization of nanomaterials able to intercalate this drug is an important study for medical and pharmaceutical field. The antibiotic inclusion into LDHs nanostructure was confirmed by advanced characterization techniques and the release profile of cefepime was analysed with the respect to pH of the simulated media.

Download Full-text