Physical - Chemical Issues of Cephalosporin Intercalated Nanoparticles for Life - Threatening Infections Treatment

The fourth generation cephalosporin antibacterial agent, cefepime, was loaded into layered double hydroxides for enhancing antibiotic efficiency, reducing side effects, as well as achieving the sustained release property. The intercalation of antibiotic into the inter-gallery of ZnAl-layered double hydroxide (LDH) was carried out using ion exchange method, by this constituting a nano-sized organic-inorganic hybrid material for a controlled release novel formulation. Although cefepime is a broad spectrum antibiotic, it has various adverse effects and a significant degradation rate. Thus, the preparation and physico-chemical characterization of nanomaterials able to intercalate this drug is an important study for medical and pharmaceutical field. The antibiotic inclusion into LDHs nanostructure was confirmed by advanced characterization techniques and the release profile of cefepime was analysed with the respect to pH of the simulated media.

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Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

Revista de Chimie ◽

10.37358/rc.19.10.3734 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3734-3737

Keyword(s):

Resistance Mechanism ◽

Chemical Characterization ◽

Advanced Characterization ◽

Free Drug ◽

Drug Resistant ◽

Infectious Agents ◽

Physico Chemical ◽

Severe Infections ◽

Antibiotic Efficacy

Some infectious agents frequently act on human body. Multi-drug resistant microorganisms (MDR) develop the capacity to stabilize biofilms. The use of antimicrobials loaded nanoparticles can defeat antibiotic resistance mechanism. The major aim of this study was the synthesis and physico-chemical characterization of Colistin molecules intercalated nanoparticles in order to enhance antibiotic efficacy against multi-drug resistant microorganisms. Advanced characterization techniques were used to analyze new nanostructures containing antibiotics in order to improve antimicrobial efficacy of the free drug. Nano-encapsulated Colistin is presumed to be more efficient in the eradication of severe infections caused by MDR. Keywords: nanoparticles, Colistin, infection, sepsis, pediatrics, epidemiology, neurosurgery, cardiology, pulmonology

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Preparation and Characterization of New Hybrid Materials Type Layered Double Hydroxides Intercalated with 4,6-dinitro-o-cresols

Revista de Chimie ◽

10.37358/rc.08.2.1726 ◽

2008 ◽

Vol 59 (2) ◽

pp. 165-167

Author(s):

Mihaela Frunza ◽

Gabriela Lisa ◽

Marcel Ionel Popa

Keyword(s):

Layered Double Hydroxides ◽

Chemical Characterization ◽

X Ray Diffraction ◽

X Ray ◽

Fourier Transformed Infrared Spectroscopy ◽

Physico Chemical ◽

Double Hydroxides ◽

Synthesized Materials ◽

Analysis Point

The paper presents the tailoring synthesis and physico-chemical characterization of layered double hydroxides (LDH) intercalated with 4,6-dinitro-o-cresol (DNOC) by coprecipitation method. The X-ray diffraction (DRX), Fourier transformed infrared spectroscopy (FTIR) and thermogravimetric (TG -DTG) analysis point out the presence of the organic compound in the network structure of the synthesized materials. Considering together the pesticide activity of 4,6-dinitro-o-cresol and the biocompatibility of the layered double hydroxides the new synthesized materials could open interesting perspectives for obtaining more environmentally friendly insecticides.

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Synthesis and Characterization of Colistin Loaded Nanoparticles Used to Combat Multi-drug Resistant Microorganisms

Revista de Chimie ◽

10.37358/rc.19.10.7635 ◽

2019 ◽

Vol 70 (10) ◽

pp. 3734-3737

Author(s):

Daniela Luminita Ichim ◽

Letitia Doina Duceac ◽

Constantin Marcu ◽

Alin Constantin Iordache ◽

Irina Mihaela Ciomaga ◽

...

Keyword(s):

Resistance Mechanism ◽

Chemical Characterization ◽

Advanced Characterization ◽

Free Drug ◽

Drug Resistant ◽

Infectious Agents ◽

Physico Chemical ◽

Severe Infections ◽

Antibiotic Efficacy

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Elaboration and Physico-Chemical Characterization of the Gibbsite Li(OH)3 Hybrid Material

Engineering, Technology & Applied Science Research ◽

10.48084/etasr.3988 ◽

2021 ◽

Vol 11 (1) ◽

pp. 6740-6744

Author(s):

N. el H. Belkham ◽

D. Benachour ◽

A. Mehamha

Keyword(s):

Hybrid Material ◽

Chemical Properties ◽

Chemical Characterization ◽

Functional Materials ◽

Point Of View ◽

Physico Chemical ◽

Physicochemical Methods ◽

Alumina Trihydrate ◽

Double Hydroxides

A hybrid material can be defined as a combination of two components of different chemical nature. The combination of a mineral matrix and organic matter has multiple significance. From a chemical point of view, it allows the obtaining of bi-functional materials that combine the chemical properties of their components. The development of new materials with specific properties and nanostructured Lamellar Double Hydroxides (LDHs) has been widely investigated due to their great importance. This study focuses on the development of a hybrid material consisting of a matrix of alumina trihydrate Al(OH)3 (gibbsite). Previous studies on the synthesis of suspension LDHs by lithium salts intercalation in a gibbsite matrix were examined, while the obtained samples were characterized by different physicochemical methods.

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