Impacts of reference points and reference lines on the slope- and area-based heart rate asymmetry analysis

Attention deficit/hyperactivity disorder (ADHD) is associated with complex neurocardiac integrity. We aimed to study heart rate time asymmetry as a nonlinear qualitative feature of heart rate variability indicating complexity of cardiac autonomic control at rest and in response to physiological stress (orthostasis) in children suffering from ADHD. Twenty boys with ADHD and 20 healthy age-matched boys at the age of 8 to 12 years were examined. The continuous ECG was recorded in a supine position and during postural change from lying to standing (orthostasis). Time irreversibility indices – Porta’s (P%), Guzik’s (G%) and Ehlers’ (E) – were evaluated. Our analysis showed significantly reduced heart rate asymmetry indices at rest (P%: 49.8 % vs. 52.2 %; G%: 50.2 % vs. 53.2 %; p<0.02), and in response to orthostatic load (P%: 52.4 % vs. 54.5 %, G%: 52.3 % vs. 54.5 %; p<0.05) associated with tachycardia in ADHD children compared to controls. Concluding, our study firstly revealed the altered heart rate asymmetry pattern in children suffering from ADHD at rest as well as in response to posture change from lying to standing (orthostasis). These findings might reflect an abnormal complex cardiac regulatory system as a potential mechanism leading to later cardiac adverse outcomes in ADHD.

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Heart rate asymmetry by Poincaré plots of RR intervals

Biomedical Engineering / Biomedizinische Technik ◽

10.1515/bmt.2006.054 ◽

2006 ◽

Vol 51 (4) ◽

pp. 272-275 ◽

Cited By ~ 101

Author(s):

Przemyslaw Guzik ◽

Jaroslaw Piskorski ◽

Tomasz Krauze ◽

Andrzej Wykretowicz ◽

Henryk Wysocki

Keyword(s):

Heart Rate ◽

Rr Intervals ◽

Rate Asymmetry ◽

Heart Rate Asymmetry

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Effect of gender and diabetes on major depressive disorder using heart rate asymmetry

2014 36th Annual International Conference of the IEEE Engineering in Medicine and Biology Society ◽

10.1109/embc.2014.6945160 ◽

2014 ◽

Author(s):

Chandan K. Karmakar ◽

Herbert F. Jelinek ◽

Paul Warner ◽

Ahsan H. Khandoker ◽

Marimuthu Palaniswami

Keyword(s):

Heart Rate ◽

Major Depressive Disorder ◽

Depressive Disorder ◽

Major Depressive ◽

Rate Asymmetry ◽

Heart Rate Asymmetry

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Obstructive sleep apnea and heart rate asymmetry microstructure during sleep

Clinical Autonomic Research ◽

10.1007/s10286-013-0188-8 ◽

2013 ◽

Vol 23 (2) ◽

pp. 91-100 ◽

Cited By ~ 19

Author(s):

Przemyslaw Guzik ◽

Jaroslaw Piskorski ◽

Kokab Awan ◽

Tomasz Krauze ◽

Michael Fitzpatrick ◽

...

Keyword(s):

Heart Rate ◽

Obstructive Sleep Apnea ◽

Sleep Apnea ◽

Rate Asymmetry ◽

Obstructive Sleep ◽

Heart Rate Asymmetry

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Heart Rate Asymmetry in Response to Colored Light

2017 Computing in Cardiology Conference (CinC) ◽

10.22489/cinc.2017.320-369 ◽

2017 ◽

Author(s):

Saman Parvaneh ◽

Nader Jafarnia Dabanloo ◽

Shahab Rezaei ◽

Sadaf Moharreri ◽

Nima Toosizadeh

Keyword(s):

Heart Rate ◽

Rate Asymmetry ◽

Heart Rate Asymmetry

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Effects of respiratory time ratio on heart rate variability and spontaneous baroreflex sensitivity

Journal of Applied Physiology ◽

10.1152/japplphysiol.00163.2013 ◽

2013 ◽

Vol 115 (11) ◽

pp. 1648-1655 ◽

Cited By ~ 20

Author(s):

Yong-Ping Wang ◽

Terry B. J. Kuo ◽

Chun-Ting Lai ◽

Jui-Wen Chu ◽

Cheryl C. H. Yang

Keyword(s):

Heart Rate ◽

Heart Rate Variability ◽

Baroreflex Sensitivity ◽

Sitting Position ◽

Relative Timing ◽

Paced Breathing ◽

Time Ratio ◽

Rate Asymmetry ◽

Heart Rate Asymmetry ◽

Spontaneous Baroreflex

Paced breathing is a frequently performed technique for cardiovascular autonomic studies. The relative timing of inspiration and expiration during paced breathing, however, is not consistent. We, therefore, examined whether indexes of heart rate variability and spontaneous baroreflex sensitivity would be affected by the respiratory time ratio that is set. We studied 14 healthy young adults who controlled their breathing rates to either 0.1 or 0.25 Hz in the supine and sitting positions. Four different inspiratory-to-expiratory time ratios (I/E) (uncontrolled, 1:1, 1:2, and 1:3) were examined for each condition in a randomized order. The results showed spectral indexes of heart rate variability and spontaneous baroreflex sensitivity were not influenced by the I/E that was set during paced breathing under supine and sitting positions. Porta's and Guzik's indexes of heart rate asymmetry were also not different at various I/E during 0.1-Hz breathing, but had larger values at 1:1 during 0.25-Hz breathing, although significant change was found in the sitting position only. At the same time, Porta's and Guzik's indexes obtained during 0.1-Hz breathing were greater than during 0.25-Hz breathing in both positions. The authors suggest that setting the I/E during paced breathing is not necessary when measuring spectral indexes of heart rate variability and spontaneous baroreflex sensitivity under the conditions used in this study. The necessity of paced breathing for the measurement of heart rate asymmetry, however, requires further investigation.

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Analysis of fetal heart rate asymmetry before and after 35 weeks of gestation

Biomedical Signal Processing and Control ◽

10.1016/j.bspc.2015.05.010 ◽

2015 ◽

Vol 21 ◽

pp. 43-48 ◽

Cited By ~ 8

Author(s):

Chandan Karmakar ◽

Yoshitaka Kimura ◽

Marimuthu Palaniswami ◽

Ahsan Khandoker

Keyword(s):

Heart Rate ◽

Fetal Heart Rate ◽

Fetal Heart ◽

Rate Asymmetry ◽

Heart Rate Asymmetry ◽

Before And After

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The effect of passive lower limb training on heart rate asymmetry

Physiological Measurement ◽

10.1088/1361-6579/ac43c1 ◽

2021 ◽

Author(s):

Ping Shi ◽

Anan Li ◽

Liang Wu ◽

Hongliu Yu

Keyword(s):

Heart Rate ◽

Time Series ◽

Heart Rate Variability ◽

Sinus Rhythm ◽

Lower Limb ◽

Automatic Regulation ◽

Training Methods ◽

Rate Asymmetry ◽

Heart Rate Asymmetry ◽

Healthy Participants

Abstract Objective: Heart rate asymmetry (HRA) is an approach for quantitatively assessing the uneven distribution of heart rate accelerations and decelerations for sinus rhythm. We aimed to investigate whether automatic regulation led to HRA alternation during passive lower limb training. Methods: Thirty healthy participants were recruited in this study. The protocol included a baseline (Pre-E) and three passive lower limb training trials (E1, E2 and E3) with a randomized order. Several variance-based HRA variables were established. Heart rate variability (HRV) parameters, i.e., mean RR, SDNN, RMSSD, LF (n.u.), HF (n.u.) and VLF (ms2), and HRA variables, i.e., SD1a, SD1d, SD2a, SD2d, SDNNa and SDNNd, were calculated by using 5-min RR time series, as well as the normalized HRA variables, i.e., C1a, C1d, C2a, C2d, Ca and Cd. Results: Our results showed that the performance of HRA was distinguished. The normalized HRA was observed with significant changes in E1, E2 and E3 compared to Pre -E. Moreover, parts of non-normalized HRA variables correlated with HRV parameters, which indicated that HRA might benefit in assessing cardiovascular modulation in passive lower limb training. Conclusions: In summary, this study suggested that passive training led to significant HRA alternation and the application of HRA gave us the possibility for autonomic assessment.

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