Simultaneous Kaposi's sarcoma and Castleman's disease in a HIV-negative patient. Response to rituximab and doxorubicin

Multicentric Castleman's disease (MCD) is an atypical lymphoproliferative disorder defined using clinical and pathologic criteria. A characteristic of the MCD is a close association with Kaposi's sarcoma (KS), which occurs during the clinical course of most human immunodeficiency virus (HIV)-associated MCD cases and also, but less frequently, in HIV-negative patients. Recently, sequences of a putative new Herpesvirus (KSHV) have been isolated and further detected in almost all the acquired immunodeficiency syndrome (AIDS) KS and in most of the non-AIDS KS samples. In this study, we searched for these Herpesvirus-like sequences in MCD samples of 31 patients. KSHV sequences were detected in 14 of 14 cases of HIV-associated MCD, including 5 cases without detectable KS. Moreover, KSHV was detected in 7 of 17 MCD cases in HIV-negative patients, including 1 case associated with a cutaneous KS. In 34 non-MCD reactive lymph nodes (follicular and/or interfollicular hyperplasia) in HIV-negative patients, KSHV was detected in only 1 case. In 1 HIV-negative case of MCD, KSHV was found in both the lymph node and peripheral blood samples. These data suggest that KSHV could play a role in the pathogenesis of MCD, especially in HIV-infected patients.

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Multicentric Castleman's disease and Kaposi's sarcoma in a cyclosporin treated, HIV-1 negative patient: case report

BMC Hematology ◽

10.1186/1471-2326-3-3 ◽

2003 ◽

Vol 3 (1) ◽

Cited By ~ 4

Author(s):

JM Bollen ◽

AM Polstra ◽

AC van der Kuyl ◽

JF Weel ◽

LA Noorduyn ◽

...

Keyword(s):

Case Report ◽

Kaposi's Sarcoma ◽

Castleman’S Disease ◽

Kaposi’S Sarcoma ◽

Castleman's Disease ◽

Multicentric Castleman’S Disease ◽

Patient Case ◽

Negative Patient ◽

Multicentric Castleman's Disease ◽

Hiv 1

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Distinct expression of Kaposi's sarcoma-associated herpesvirus-encoded proteins in Kaposi's sarcoma and multicentric Castleman's disease

Pathology International ◽

10.1111/j.1440-1827.2006.02017.x ◽

2006 ◽

Vol 56 (10) ◽

pp. 617-624 ◽

Cited By ~ 19

Author(s):

Yasuhisa Abe ◽

Daisuke Matsubara ◽

Hiroyuki Gatanaga ◽

Shinichi Oka ◽

Satoshi Kimura ◽

...

Keyword(s):

Kaposi's Sarcoma ◽

Castleman’S Disease ◽

Kaposi’S Sarcoma ◽

Castleman's Disease ◽

Multicentric Castleman’S Disease ◽

Encoded Proteins ◽

Kaposi's Sarcoma Associated Herpesvirus ◽

Kaposi’S Sarcoma Associated Herpesvirus ◽

Multicentric Castleman's Disease

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Kaposi’s sarcoma in an HIV-negative patient

Dermatology Online Journal ◽

10.5070/d32212033378 ◽

2016 ◽

Vol 22 (12) ◽

Author(s):

Shields Callahan ◽

Randie H Kim ◽

Nooshin Brinster ◽

Jo-Ann Latkowski

Keyword(s):

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Negative Patient ◽

Hiv Negative

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Simultaneous Association of Pulmonary Tuberculosis and Kaposi’s Sarcoma in an Immunocompetent Subject: A Case Report and Literature Review

Case Reports in Pulmonology ◽

10.1155/2019/5453031 ◽

2019 ◽

Vol 2019 ◽

pp. 1-3

Author(s):

Sofia Baina ◽

Jihane Achrane ◽

Jouda Benamor ◽

Jamal Eddine Bourkadi

Keyword(s):

Case Report ◽

Literature Review ◽

Pulmonary Tuberculosis ◽

Kaposi's Sarcoma ◽

Kaposi’S Sarcoma ◽

Hiv Positive ◽

Negative Patient ◽

Different Types ◽

Hiv Negative

Kaposi’s Sarcoma (KS) occurs as a pathological entity that may be classified into four different types: classic, endemic, epidemic, and iatrogenic. It can arise among HIV-positive subjects or within immunosuppression, yet exceptionally of tuberculous origin. We describe a new case report of an HIV-negative patient, manifesting Kaposi’s disease in the course of tuberculosis, with the aim to assess this uncommon disorder and to outline this rare atypical association.

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