Mechanisms of illness during respiratory syncytial virus infection: the lungs, the virus and the immune response

2004 ◽  
Vol 6 (8) ◽  
pp. 767-772 ◽  
Author(s):  
Scott J. Hoffman ◽  
Federico R. Laham ◽  
Fernando P. Polack
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Syncytial Virus

Primary respiratory syncytial virus infection: pathology, immune response, and evaluation of vaccine challenge strains in a new mouse model

Vaccine ◽  
2000 ◽  
Vol 18 (14) ◽  
pp. 1412-1418 ◽  
Author(s):  
Anne M Stack ◽  
Richard Malley ◽  
Richard A Saladino ◽  
John B Montana ◽  
Kristin L MacDonald ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Mouse Model ◽  
Respiratory Syncytial Virus Infection ◽  
Syncytial Virus

scholarly journals Evidence for an intranasal immune response to human respiratory syncytial virus infection in cynomolgus macaques

2015 ◽  
Vol 96 (4) ◽  
pp. 782-792 ◽  
Author(s):  
Clément Grandin ◽  
Marianne Lucas-Hourani ◽  
Marine Clavel ◽  
Fabrice Taborik ◽  
Astrid Vabret ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Human Respiratory Syncytial Virus ◽  
Cynomolgus Macaques ◽  
Syncytial Virus

Functional and immune response to respiratory syncytial virus infection in aged BALB/c mice: A search for genes determining disease severity

2013 ◽  
Vol 40 (1) ◽  
pp. 40-49 ◽  
Author(s):  
Ricardo A. Mosquera ◽  
James M. Stark ◽  
Constance L. Atkins ◽  
Guiseppe N. Colasurdo ◽  
Justyna Chevalier ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Disease Severity ◽  
Respiratory Syncytial Virus Infection ◽  
Syncytial Virus

scholarly journals Nasopharyngeal Haemophilus and local immune response during infant respiratory syncytial virus infection

2020 ◽  
Author(s):  
Meghan H. Shilts ◽  
Christian Rosas-Salazar ◽  
Kedir N. Turi ◽  
Devi Rajan ◽  
Seesandra V. Rajagopala ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Local Immune Response ◽  
Syncytial Virus

scholarly journals Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection

Pathogens ◽  
2019 ◽  
Vol 8 (3) ◽  
pp. 106 ◽  
Author(s):  
Glaser ◽  
Coulter ◽  
Shields ◽  
Touzelet ◽  
Power ◽  
...  
Keyword(s):  
Immune Response ◽  
Respiratory Syncytial Virus ◽  
Virus Infection ◽  
Respiratory Syncytial Virus Infection ◽  
Immune Cells ◽  
Airway Epithelial ◽  
Antiviral Immune Response ◽  
Cytokines And Chemokines ◽  
Rsv Infection ◽  
Syncytial Virus

The airway epithelium is the primary target of respiratory syncytial virus infection. It is an important component of the antiviral immune response. It contributes to the recruitment and activation of innate immune cells from the periphery through the secretion of cytokines and chemokines. This paper provides a broad review of the cytokines and chemokines secreted from human airway epithelial cell models during respiratory syncytial virus (RSV) infection based on a comprehensive literature review. Epithelium-derived chemokines constitute most inflammatory mediators secreted from the epithelium during RSV infection. This suggests chemo-attraction of peripheral immune cells, such as monocytes, neutrophils, eosinophils, and natural killer cells as a key function of the epithelium. The reports of epithelium-derived cytokines are limited. Recent research has started to identify novel cytokines, the functions of which remain largely unknown in the wider context of the RSV immune response. It is argued that the correct choice of in vitro models used for investigations of epithelial immune functions during RSV infection could facilitate greater progress in this field.

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