Study of Lewis acid accelerated palladium catalyzed C H activation

2017 ◽  
Vol 426 ◽  
pp. 444-450 ◽  
Author(s):  
Orsolya Tischler ◽  
Szabolcs Kovács ◽  
Gábor Érsek ◽  
Péter Králl ◽  
János Daru ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Palladium Catalyzed

scholarly journals Palladium-catalyzed cross coupling reactions of 4-bromo-6H-1,2-oxazines

2009 ◽  
Vol 5 ◽  
Author(s):  
Reinhold Zimmer ◽  
Elmar Schmidt ◽  
Michal Andrä ◽  
Marcel-Antoine Duhs ◽  
Igor Linder ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Cross Coupling ◽  
Pyridine Derivative ◽  
Coupling Reactions ◽  
Cross Coupling Reactions ◽  
Palladium Catalyzed

A number of 4-aryl- and 4-alkynyl-substituted 6H-1,2-oxazines 8 and 9 have been prepared in good yields via cross coupling reactions of halogenated precursors 2, which in turn are easily accessible by bromination of 6H-1,2-oxazines 1. Lewis-acid promoted reaction of 1,2-oxazine 9c with 1-hexyne provided alkynyl-substituted pyridine derivative 12 thus demonstrating the potential of this approach for the synthesis of pyridines.

scholarly journals Synthesis of 2-Alkenyl-Tethered Anilines

Synthesis ◽  
2017 ◽  
Vol 49 (13) ◽  
pp. 2873-2888 ◽  
Author(s):  
Scott Denmark ◽  
Hyung Chi
Keyword(s):  
Lewis Acid ◽  
Cross Coupling ◽  
Aryl Halides ◽  
Cope Rearrangement ◽  
The Third ◽  
Cross Metathesis ◽  
Direct Cross ◽  
Palladium Catalyzed

Three general routes for the synthesis of (E)-2-alkenyl-tethered anilines have been developed. The first route involves a 3-aza-Cope rearrangement of N-allylic anilines in the presence of a Lewis acid. The requisite N-allylic anilines were prepared by the addition of vinylmagnesium reagents to the corresponding aldimines. The second route details a direct cross-metathesis of 2-allylic or 2-homoallylic anilines with styrenes. The third route involves a palladium-catalyzed C–N cross-coupling of aryl halides. Taken together, these three strategies allowed access to the requisite aniline substrates with pendant alkenes at the 2-position with excellent trans selectivities.

Palladium-Catalyzed/Lewis Acid-Promoted Alkene Dimerization and Cross-Coupling with AlcoholsviaCH Bond Activation

2008 ◽  
Vol 350 (4) ◽  
pp. 552-556 ◽  
Author(s):  
Yi-Jun Jiang ◽  
Yong-Qiang Tu ◽  
En Zhang ◽  
Shu-Yu Zhang ◽  
Ke Cao ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Bond Activation ◽  
Cross Coupling ◽  
Palladium Catalyzed

Role of Lewis acid additives in a palladium catalyzed directed C–H functionalization reaction of benzohydroxamic acid to isoxazolone

2017 ◽  
Vol 15 (1) ◽  
pp. 246-255 ◽  
Author(s):  
C. Athira ◽  
Raghavan B. Sunoj
Keyword(s):  
Lewis Acid ◽  
Pivalic Acid ◽  
Bond Functionalization ◽  
Benzohydroxamic Acid ◽  
Palladium Catalyzed ◽  
Functionalization Reaction

The role of additives, pivalic acid and ZnCl2, in a Pd-catalyzed directed C–H bond functionalization reaction is established.

Organoboron compounds as mild nucleophiles in Lewis acid- and transition metal-catalyzed C­C bond-forming reactions

2002 ◽  
Vol 74 (1) ◽  
pp. 43-55 ◽  
Author(s):  
Robert A. Batey ◽  
Tan D. Quach ◽  
Ming Shen ◽  
Avinash N. Thadani ◽  
David V. Smil ◽  
...  
Keyword(s):  
Lewis Acid ◽  
Coupling Reactions ◽  
Rhodium Catalysis ◽  
Organoboron Compounds ◽  
Bond Forming ◽  
Acyliminium Ions ◽  
Cross Coupling Reactions ◽  
Bond Forming Reactions ◽  
Palladium Catalyzed ◽  
Metal Catalyzed

The use of air- and water-stable organoboron compounds for C­C bond-forming reactions are reported. These studies include the Lewis acid-promoted additions of boronic esters to N-acyliminium ions and allyl and crotyltrifluoroborate salts to aldehydes. Aryl and alkenyltrifluoroborate salts will add to aldehydes under the influence of rhodium catalysis or in the presence of zinc metal. These salts also participate in palladium-catalyzed Suzuki­Miyaura and other cross-coupling reactions. Finally, a new type of N-heterocyclic carbene ligand is reported and used for Pd-catalyzed Suzuki­Miyaura couplings.

Rate enhancement in palladium catalyzed Heck reactions by Lewis acid promoters

2007 ◽  
Vol 8 (2) ◽  
pp. 183-186 ◽  
Author(s):  
Abhishek Sud ◽  
Raj Madhukar Deshpande ◽  
Raghunath Vitthal Chaudhari
Keyword(s):  
Lewis Acid ◽  
Heck Reactions ◽  
Rate Enhancement ◽  
Palladium Catalyzed
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